{"id":"https://openalex.org/W2419242574","doi":"https://doi.org/10.1038/srep22807","title":"Intracellular acidification is required for full activation of the sweet taste receptor by miraculin","display_name":"Intracellular acidification is required for full activation of the sweet taste receptor by miraculin","publication_year":2016,"publication_date":"2016-03-10","ids":{"openalex":"https://openalex.org/W2419242574","doi":"https://doi.org/10.1038/srep22807","mag":"2419242574","pmid":"https://pubmed.ncbi.nlm.nih.gov/26960429","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4785348"},"language":"en","primary_location":{"id":"doi:10.1038/srep22807","doi":"https://doi.org/10.1038/srep22807","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep22807","pdf_url":"https://www.nature.com/articles/srep22807.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep22807.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042637006","display_name":"Keisuke Sanematsu","orcid":"https://orcid.org/0000-0002-8532-7429","observed_orcids":["https://orcid.org/0000-0002-8532-7429"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Sanematsu","raw_affiliation_strings":["Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masayuki Kitagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Kitagawa","raw_affiliation_strings":["Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019710427","display_name":"Ryusuke Yoshida","orcid":"https://orcid.org/0000-0001-7584-9437","observed_orcids":["https://orcid.org/0000-0001-7584-9437"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryusuke Yoshida","raw_affiliation_strings":["OBT Research Center, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OBT Research Center, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051080234","display_name":"Satoru Nirasawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089209","display_name":"Japan International Research Center for Agricultural Sciences","ror":"https://ror.org/005pdtr14","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210089209"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Nirasawa","raw_affiliation_strings":["Japan International Research Center for Agricultural Sciences, 1-1 Ohwashi, Tsukuba, Ibaraki 305-8686, Japan","Japan International Research Center for Agricultural Sciences, 1-1 Ohwashi, Tsukuba, 305-8686, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan International Research Center for Agricultural Sciences, 1-1 Ohwashi, Tsukuba, Ibaraki 305-8686, Japan","institution_ids":["https://openalex.org/I4210089209"]},{"raw_affiliation_string":"Japan International Research Center for Agricultural Sciences, 1-1 Ohwashi, Tsukuba, 305-8686, Ibaraki, Japan","institution_ids":["https://openalex.org/I4210089209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054894206","display_name":"Noriatsu Shigemura","orcid":"https://orcid.org/0000-0002-3061-6362","observed_orcids":["https://orcid.org/0000-0002-3061-6362"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriatsu Shigemura","raw_affiliation_strings":["Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012891699","display_name":"Yuzo Ninomiya","orcid":"https://orcid.org/0000-0003-4822-7880","observed_orcids":["https://orcid.org/0000-0003-4822-7880"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yuzo Ninomiya","raw_affiliation_strings":["Division of Sensory Physiology, Research and Development Center for Taste and Odor sensing, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","Division of Sensory Physiology, Research and Development Center for Taste and Odor sensing, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Sensory Physiology, Research and Development Center for Taste and Odor sensing, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Division of Sensory Physiology, Research and Development Center for Taste and Odor sensing, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012891699"],"corresponding_institution_ids":["https://openalex.org/I135598925"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":3.8325,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.91865996,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"1","first_page":"22807","last_page":"22807"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/miraculin","display_name":"miraculin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/sweet-taste-receptor","display_name":"sweet taste receptor","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tas1r2","display_name":"TAS1R2","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tas1r3","display_name":"TAS1R3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intracellular-acidification","display_name":"intracellular acidification","score":0.984000027179718},{"id":"https://openalex.org/keywords/ph-dependence","display_name":"pH dependence","score":0.7699999809265137},{"id":"https://openalex.org/keywords/citric-acid","display_name":"citric acid","score":0.953000009059906},{"id":"https://openalex.org/keywords/histidine-residues","display_name":"histidine residues","score":0.7540000081062317},{"id":"https://openalex.org/keywords/hek293-cells","display_name":"HEK293 cells","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C178006227","wikidata":"https://www.wikidata.org/wiki/Q3454532","display_name":"Taste receptor","level":3,"score":0.7502983808517456},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7469913959503174},{"id":"https://openalex.org/C2779032678","wikidata":"https://www.wikidata.org/wiki/Q159683","display_name":"Citric acid","level":2,"score":0.7338820695877075},{"id":"https://openalex.org/C8868529","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Taste","level":2,"score":0.7143856287002563},{"id":"https://openalex.org/C134897140","wikidata":"https://www.wikidata.org/wiki/Q6058355","display_name":"Intracellular pH","level":3,"score":0.6955083012580872},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6533640623092651},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6275053024291992},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5457770228385925},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.49729588627815247},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49228397011756897},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.4767088294029236},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.35603398084640503}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006851","descriptor_name":"Hydrochloric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013549","descriptor_name":"Sweetening Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019343","descriptor_name":"Citric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/srep22807","doi":"https://doi.org/10.1038/srep22807","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep22807","pdf_url":"https://www.nature.com/articles/srep22807.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3758975","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4785348","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4785348","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4785348","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:26960429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26960429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/srep22807","doi":"https://doi.org/10.1038/srep22807","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep22807","pdf_url":"https://www.nature.com/articles/srep22807.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1771718352","display_name":"Molecular and neural mechanisms for detection, modulation and transmission of taste signal for fat preference","funder_award_id":"26670810","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3109517807","display_name":"Molecular basis of taste perception and humoral modulation of taste/hormone sensing cells in the oral-gut-brain circuit and its role in regulating food intake","funder_award_id":"15H02571","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5895773346","display_name":"Analysis for the fuction of sweet receptor","funder_award_id":"25861759","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G773669248","display_name":"Analysis for interaction between sweet receptor and taste modifiers","funder_award_id":"23792128","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G831799783","display_name":"Molecular and Neural Mechanisms for Detection, Transmission and Modulation of taste signals derived from the oral cavity and gut","funder_award_id":"23249081","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8442193575","display_name":"Analysis of the sweet receptor as an energy sensor","funder_award_id":"15K11045","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8977397528","display_name":"Coding of bitter taste information among taste bud cells","funder_award_id":"26462815","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2419242574.pdf","grobid_xml":"https://content.openalex.org/works/W2419242574.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1915478014","https://openalex.org/W1945680072","https://openalex.org/W1965987186","https://openalex.org/W1968654323","https://openalex.org/W1970250202","https://openalex.org/W1973108253","https://openalex.org/W1998591058","https://openalex.org/W2009634503","https://openalex.org/W2013392190","https://openalex.org/W2024011576","https://openalex.org/W2030960760","https://openalex.org/W2031137367","https://openalex.org/W2044159862","https://openalex.org/W2044187501","https://openalex.org/W2048907155","https://openalex.org/W2050321525","https://openalex.org/W2061976713","https://openalex.org/W2067388704","https://openalex.org/W2067399891","https://openalex.org/W2067990931","https://openalex.org/W2073115006","https://openalex.org/W2093140679","https://openalex.org/W2122060463","https://openalex.org/W2140205768","https://openalex.org/W2140563610","https://openalex.org/W2155652920","https://openalex.org/W2159391450","https://openalex.org/W2176429913","https://openalex.org/W2188056439","https://openalex.org/W4249590403"],"related_works":["https://openalex.org/W2140563610","https://openalex.org/W2750911634","https://openalex.org/W1993599591","https://openalex.org/W2159391450","https://openalex.org/W2188056439","https://openalex.org/W2172096995","https://openalex.org/W2002594079","https://openalex.org/W3013897262","https://openalex.org/W1530749672","https://openalex.org/W2038416082"],"abstract_inverted_index":{"Acidification":[0],"of":[1,51,115,123,132,146,154,156,169],"the":[2,38,45,49,54,110,170],"glycoprotein,":[3],"miraculin":[4],"(MCL),":[5],"induces":[6],"sweet":[7,16,40,55,73,171],"taste":[8,17,56,172],"in":[9,13,108],"humans,":[10],"but":[11,44],"not":[12],"mice.":[14],"The":[15,61],"induced":[18,136],"by":[19,47,70,137,141,174],"MCL":[20,35,52,124,147],"is":[21,164],"more":[22],"intense":[23],"when":[24],"acidification":[25,50,131],"occurs":[26],"with":[27,37,81,90,100],"weak":[28],"acids":[29],"as":[30],"opposed":[31],"to":[32,67,98,150],"strong":[33],"acids.":[34,157],"interacts":[36],"human":[39],"receptor":[41,57,74,173],"subunit":[42],"hTAS1R2,":[43],"mechanisms":[46],"which":[48],"activates":[53],"remain":[58],"largely":[59],"unexplored.":[60],"work":[62],"reported":[63],"here":[64],"speaks":[65],"directly":[66],"this":[68],"activation":[69,168],"utilizing":[71],"a":[72,87],"TAS1R2":[75],"+":[76],"TAS1R3":[77],"assay.":[78],"In":[79],"accordance":[80],"previous":[82],"data,":[83],"MCL-applied":[84],"cells":[85,134],"displayed":[86],"pH":[88,152],"dependence":[89],"citric":[91,138],"acid":[92,102,139],"(weak":[93],"acid)":[94],"being":[95],"right":[96],"shifted":[97],"that":[99,161],"hydrochloric":[101],"(strong":[103],"acid).":[104],"When":[105],"histidine":[106],"residues":[107],"both":[109],"intracellular":[111,130,151,162],"and":[112,143],"extracellular":[113],"region":[114],"hTAS1R2":[116],"were":[117],"exchanged":[118],"for":[119,166],"alanine,":[120],"taste-modifying":[121,144],"effect":[122,145],"was":[125,135,148],"reduced":[126],"or":[127],"abolished.":[128],"Stronger":[129],"HEK293":[133],"than":[140],"HCl":[142],"proportional":[149],"regardless":[153],"types":[155],"These":[158],"results":[159],"suggest":[160],"acidity":[163],"required":[165],"full":[167],"MCL.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
