{"id":"https://openalex.org/W2419173232","doi":null,"title":"Pyelonephritis. X. Microbial interference in streptococcal infections in the rat kidney.","display_name":"Pyelonephritis. X. Microbial interference in streptococcal infections in the rat kidney.","publication_year":1969,"publication_date":"1969-08-01","ids":{"openalex":"https://openalex.org/W2419173232","mag":"2419173232","pmid":"https://pubmed.ncbi.nlm.nih.gov/4979143"},"language":"en","primary_location":{"id":"pmid:4979143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4979143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111527465","display_name":"Lucien B. Guze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L B Guze","raw_affiliation_strings":["From the Department of Medicine, UCLA School of Medicine Los Angeles, Calif. USA","From the Research and Medical Services, Wadsworth Hospital, Veterans Administration Center, Los Angeles, Calif. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, UCLA School of Medicine Los Angeles, Calif. USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"From the Research and Medical Services, Wadsworth Hospital, Veterans Administration Center, Los Angeles, Calif. USA","institution_ids":["https://openalex.org/I1322918889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021757498","display_name":"EARL G. HUBERT","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E G Hubert","raw_affiliation_strings":["From the Department of Medicine, UCLA School of Medicine Los Angeles, Calif. USA","From the Research and Medical Services, Wadsworth Hospital, Veterans Administration Center, Los Angeles, Calif. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, UCLA School of Medicine Los Angeles, Calif. USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"From the Research and Medical Services, Wadsworth Hospital, Veterans Administration Center, Los Angeles, Calif. USA","institution_ids":["https://openalex.org/I1322918889"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109924958","display_name":"GEORGE M. KALMANSON","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G M Kalmanson","raw_affiliation_strings":["From the Department of Medicine, UCLA School of Medicine Los Angeles, Calif. USA","From the Research and Medical Services, Wadsworth Hospital, Veterans Administration Center, Los Angeles, Calif. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, UCLA School of Medicine Los Angeles, Calif. USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"From the Research and Medical Services, Wadsworth Hospital, Veterans Administration Center, Los Angeles, Calif. USA","institution_ids":["https://openalex.org/I1322918889"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"2","first_page":"274","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.03519999980926514,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyelonephritis","display_name":"pyelonephritis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/bacteriocins","display_name":"bacteriocins","score":0.7009999752044678},{"id":"https://openalex.org/keywords/interbacterial-competition","display_name":"bacterial competition","score":0.40400001406669617},{"id":"https://openalex.org/keywords/hematogenous-infection","display_name":"hematogenous infection","score":0.7239999771118164},{"id":"https://openalex.org/keywords/osmolality","display_name":"osmolality","score":0.781000018119812},{"id":"https://openalex.org/keywords/ph","display_name":"pH","score":0.5690000057220459},{"id":"https://openalex.org/keywords/urea","display_name":"urea","score":0.7089999914169312},{"id":"https://openalex.org/keywords/creatinine","display_name":"creatinine","score":0.824999988079071},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.593999981880188},{"id":"https://openalex.org/keywords/rat-kidney","display_name":"rat kidney","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C115574571","wikidata":"https://www.wikidata.org/wiki/Q183119","display_name":"Bacteriocin","level":3,"score":0.8957545161247253},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7593250870704651},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.7109668254852295},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6681699752807617},{"id":"https://openalex.org/C2779895986","wikidata":"https://www.wikidata.org/wiki/Q140014","display_name":"Enterococcus faecalis","level":4,"score":0.5716514587402344},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5654688477516174},{"id":"https://openalex.org/C2778276568","wikidata":"https://www.wikidata.org/wiki/Q190161","display_name":"Streptococcus","level":3,"score":0.5523699522018433},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5183680653572083},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.500664234161377},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.4906567633152008},{"id":"https://openalex.org/C2778660310","wikidata":"https://www.wikidata.org/wiki/Q177998","display_name":"Agar","level":3,"score":0.488974928855896},{"id":"https://openalex.org/C2778597767","wikidata":"https://www.wikidata.org/wiki/Q4027534","display_name":"Sucrose","level":2,"score":0.4779253602027893},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43421176075935364},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4276354908943176},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3374856114387512},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.2941676378250122},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23927798867225647},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.21340662240982056},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08583074808120728},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.07880797982215881},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.07334563136100769},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07098272442817688},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001430","descriptor_name":"Bacteriocins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001431","descriptor_name":"Bacteriological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011704","descriptor_name":"Pyelonephritis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013290","descriptor_name":"Streptococcal Infections","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4979143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4979143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:2419173232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4979143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W140392627","https://openalex.org/W170044563","https://openalex.org/W236396041","https://openalex.org/W1499091797","https://openalex.org/W1586904106","https://openalex.org/W1589067476","https://openalex.org/W1928550730","https://openalex.org/W1972002605","https://openalex.org/W1982010367","https://openalex.org/W2008416649","https://openalex.org/W2018867870","https://openalex.org/W2044779744","https://openalex.org/W2060744922","https://openalex.org/W2066674728","https://openalex.org/W2075831910","https://openalex.org/W2085387115","https://openalex.org/W2088194979","https://openalex.org/W2143607567","https://openalex.org/W2148937162","https://openalex.org/W2158210480","https://openalex.org/W2167646937","https://openalex.org/W2263985829","https://openalex.org/W2320546303","https://openalex.org/W2471661379","https://openalex.org/W4319717423"],"related_works":["https://openalex.org/W2321153726","https://openalex.org/W1865699473","https://openalex.org/W2083425436","https://openalex.org/W2414773066","https://openalex.org/W2322750765","https://openalex.org/W2065938668","https://openalex.org/W602358676","https://openalex.org/W7098065314","https://openalex.org/W1827320070","https://openalex.org/W2059344642"],"abstract_inverted_index":{"Abstract":[0],"Interactions":[2],"of":[3,6,27,36,44,56,61,90,238,244,247],"bacteriocin-producing":[4,109],"strains":[5],"Streptococcus":[8],"faccalis":[9],"were":[11,21,99],"studied":[12],"in":[13,16,82,97,105,170,177,206,234],"vitro":[14,178],"and":[15,53,80,93,227],"vivo.":[17],"In":[18],"addition,":[19],"experiments":[20],"done":[22,100],"to":[23,31,122,204,219],"evaluate":[24],"the":[25,32,57,106,146,163,168,180,208,236,248],"effect":[26,243],"physico-chemical":[28,245],"parameters":[29],"unique":[30],"kidney":[33,215,249],"on":[34,88,251],"interactions":[35],"selected":[37],"organisms.":[38],"This":[39],"was":[40,68,120,195,202],"accomplished":[41],"by":[42],"incorporation":[43],"sodium":[45],"or":[46,142],"potassium":[47],"chloride,":[48],"urea,":[49],"creatihine,":[50],"varying":[51],"pH,":[52],"increasing":[54],"osmolality":[55],"agar":[58],"(sucrose).":[59],"Effect":[60],"excess":[62],"glucose":[63],"as":[64,179],"an":[65,231],"energy":[66],"source":[67],"evaluated.":[69],"While":[70],"results":[71,169],"did":[72,172],"not":[73,173],"follow":[74],"a":[75],"predictable":[76],"pattern,":[77],"both":[78],"increase":[79],"decrease":[81],"inhibition":[83],"could":[84],"be":[85],"demonstrated,":[86],"depending":[87],"combination":[89],"organisms":[91],"used":[92],"parameter":[94],"studied.":[95],"Studies":[96],"vivo":[98,171],"with":[101,162,198],"experimental":[102],"hematogenous":[103],"pyelonephritis":[104],"rat.":[107],"The":[108],"strain":[110,166,182,199],"(":[111],"S.":[112,130,188],"faecalis":[113,131,189],"variety":[115],"(var.)":[116],"zymogenes":[118,193],")":[119],"able":[121],"inhibit":[123],"but":[124,213],"never":[125],"completely":[126],"eliminate":[127],"susceptible":[128,157,165,181],"G-K":[133,147],"whether":[134],"given":[135,150,196],"one":[136,143],"week":[137,144],"prior":[138],"to,":[139],"simultaneously":[140,197],"with,":[141],"after":[145],"strain.":[148],"When":[149,186],"simultaneously,":[151],"it":[152,205],"also":[153],"predominated":[154],"over":[155],"another":[156],"strain,":[158],"ATCC":[159],"9790.":[160],"However,":[161,242],"less":[164],"3256,":[167],"parallel":[174],"those":[175],"noted":[176],"became":[183],"more":[184],"numerous.":[185],"var.":[191],"2866":[200],"which":[201],"resistant":[203],"vitro,":[207],"latter":[209],"at":[210],"first":[211],"predominated,":[212],"subsequently":[214],"bacterial":[216],"populations":[217],"tended":[218],"equalize.":[220],"These":[221],"data":[222],"suggest":[223],"that":[224],"bacteriocin":[225,252],"production":[226],"susceptibility":[228],"thereto":[229],"play":[230],"important":[232],"role":[233],"determining":[235],"result":[237],"mixed":[239],"renal":[240],"infection.":[241],"characteristics":[246],"environment":[250],"activity":[253],"may":[254],"determine":[255],"final":[256],"outcome.":[257]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}