{"id":"https://openalex.org/W2419082510","doi":null,"title":"Regulation of ATRIP protein abundance by RAD9 in the DNA damage repair pathway.","display_name":"Regulation of ATRIP protein abundance by RAD9 in the DNA damage repair pathway.","publication_year":2015,"publication_date":"2015-12-09","ids":{"openalex":"https://openalex.org/W2419082510","mag":"2419082510","pmid":"https://pubmed.ncbi.nlm.nih.gov/26667770"},"language":"en","primary_location":{"id":"pmid:26667770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26667770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular biology (Noisy-le-Grand, France)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002446597","display_name":"X-J Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X-J Peng","raw_affiliation_strings":["Nanchang University School of Life Sciences and Institute of Life Science Nanchang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanchang University School of Life Sciences and Institute of Life Science Nanchang China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087704998","display_name":"Liu Sj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"S-J Liu","raw_affiliation_strings":["Nanchang University School of Life Sciences and Institute of Life Science Nanchang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanchang University School of Life Sciences and Institute of Life Science Nanchang China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040494933","display_name":"Bao Cm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"C-M Bao","raw_affiliation_strings":["Nanchang University School of Life Sciences and Institute of Life Science Nanchang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanchang University School of Life Sciences and Institute of Life Science Nanchang China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110374010","display_name":"Liu Yz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y-Z Liu","raw_affiliation_strings":["Nanchang University School of Life Sciences and Institute of Life Science Nanchang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanchang University School of Life Sciences and Institute of Life Science Nanchang China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057499683","display_name":"Xie Hw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165555","display_name":"Jiangxi Academy of Agricultural Sciences","ror":"https://ror.org/05ndx7902","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165555"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H-W Xie","raw_affiliation_strings":["Jiangxi Academy of Agricultural Sciences Jiangxi Super&mdash;rice Research and Development Center Nanchang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangxi Academy of Agricultural Sciences Jiangxi Super&mdash;rice Research and Development Center Nanchang China","institution_ids":["https://openalex.org/I4210165555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y-H Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165555","display_name":"Jiangxi Academy of Agricultural Sciences","ror":"https://ror.org/05ndx7902","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165555"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y-H Cai","raw_affiliation_strings":["Jiangxi Academy of Agricultural Sciences Jiangxi Super-rice Research and Development Center Nanchang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangxi Academy of Agricultural Sciences Jiangxi Super-rice Research and Development Center Nanchang China","institution_ids":["https://openalex.org/I4210165555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070270041","display_name":"Li Bm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"B-M Li","raw_affiliation_strings":["Nanchang University School of Life Sciences and Institute of Life Science Nanchang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanchang University School of Life Sciences and Institute of Life Science Nanchang China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078991611","display_name":"Hang Hy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H-Y Hang","raw_affiliation_strings":["Chinese Academy of Sciences Center for Infection and Immunity, Institute of Biophysics Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences Center for Infection and Immunity, Institute of Biophysics Beijing China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017768928","display_name":"Xiaofen Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X Ding","raw_affiliation_strings":["Nanchang University School of Life Sciences and Institute of Life Science Nanchang China dingxia97@ncu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanchang University School of Life Sciences and Institute of Life Science Nanchang China dingxia97@ncu.edu.cn","institution_ids":["https://openalex.org/I141649914"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.16286478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"61","issue":"8","first_page":"31","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrip","display_name":"ATRIP","score":0.9470000267028809},{"id":"https://openalex.org/keywords/rad9","display_name":"Rad9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/atr-chk1-pathway","display_name":"ATR-Chk1 pathway","score":0.8709999918937683},{"id":"https://openalex.org/keywords/dna-damage-checkpoint","display_name":"DNA damage checkpoint","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7580000162124634},{"id":"https://openalex.org/keywords/protein-abundance-regulation","display_name":"protein abundance regulation","score":0.546999990940094},{"id":"https://openalex.org/keywords/checkpoint-signaling","display_name":"checkpoint signaling","score":0.3959999978542328},{"id":"https://openalex.org/keywords/genotoxic-stress","display_name":"genotoxic stress","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.8158583641052246},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7634286284446716},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.7007791996002197},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.6690418124198914},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4991576671600342},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4639987349510193},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.39931583404541016},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3933524787425995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3780212998390198},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2773028612136841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2358645498752594},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1215672492980957},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09443330764770508}],"mesh":[{"descriptor_ui":"D000066450","descriptor_name":"Mouse Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D000066450","descriptor_name":"Mouse Embryonic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000066450","descriptor_name":"Mouse Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071877","descriptor_name":"Checkpoint Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005092","descriptor_name":"Exonucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005092","descriptor_name":"Exonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:26667770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26667770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular biology (Noisy-le-Grand, France)","raw_type":"Journal Article"},{"id":"mag:2419082510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26667770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2022427795","https://openalex.org/W7095840951","https://openalex.org/W2050608484","https://openalex.org/W1977858243","https://openalex.org/W2079749814","https://openalex.org/W1514911782","https://openalex.org/W1968552183","https://openalex.org/W639873284","https://openalex.org/W7074085390","https://openalex.org/W1992630665"],"abstract_inverted_index":{"Genotoxic":[0],"stress":[1],"activates":[2],"checkpoint":[3,9,58,158],"signaling":[4],"pathways":[5],"that":[6,67,78,119,145],"activate":[7],"the":[8,36,57,73,91,100,124,142,152],"kinases":[10],"ATM":[11],"and":[12,18,40,55,113,128,155],"ATR,":[13],"halt":[14],"cell":[15],"cycle":[16],"progression,":[17],"promote":[19],"DNA":[20,92,129,156],"repair.":[21],"A":[22],"number":[23],"of":[24,69,75,86,139,151],"proteins":[25,45],"act":[26,47],"in":[27,48,88,99,141],"concert":[28,49],"with":[29,50,108],"ATR":[30],"to":[31,53],"phosphorylate":[32],"Chk1,":[33],"including":[34],"RAD17,":[35],"RAD9-RAD1-HUS1":[37],"complex,":[38],"ATR/ATRIP":[39],"TopBp1.":[41],"However,":[42],"how":[43],"these":[44],"involved":[46],"one":[51],"another":[52],"propagate":[54],"maintain":[56],"response":[59],"is":[60,146],"not":[61,111],"well":[62],"understood.":[63],"Here,":[64],"we":[65,117,135],"reported":[66],"upregulation":[68],"RAD9":[70,79,120,140],"protein":[71,126],"increased":[72],"quantity":[74],"ATRIP,":[76],"suggesting":[77],"activation":[80],"will":[81],"induce":[82],"more":[83],"efficient":[84],"accumulation":[85],"ATRIP":[87,94,105,125,131],"vivo.":[89],"Furthermore,":[90],"damage-induced":[93,130],"foci":[95,132],"formation":[96,150],"was":[97],"faster":[98],"mRad9-/-":[101],"ES":[102],"cells.":[103],"Also,":[104],"interacts":[106],"specifically":[107],"RAD9,":[109],"but":[110],"HUS1":[112],"RAD1.":[114],"Taken":[115],"together,":[116],"suggested":[118],"could":[121],"affect":[122],"both":[123],"levels":[127],"formation.":[133],"Thus,":[134],"propose":[136],"a":[137],"role":[138],"ATR-Chk1":[143],"pathway":[144],"necessary":[147],"for":[148],"successful":[149],"damage-sensing":[153],"complex":[154],"damage":[157],"signaling.":[159]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
