{"id":"https://openalex.org/W24184972","doi":null,"title":"The use of amnion-derived cellular cytokine solution to improve healing in acute and chronic wound models.","display_name":"The use of amnion-derived cellular cytokine solution to improve healing in acute and chronic wound models.","publication_year":2008,"publication_date":"2008-04-11","ids":{"openalex":"https://openalex.org/W24184972","mag":"24184972","pmid":"https://pubmed.ncbi.nlm.nih.gov/18470282","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2323202"},"language":"en","primary_location":{"id":"pmid:18470282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18470282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eplasty","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2323202/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110887598","display_name":"Michael Franz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G Franz","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, USA. mfranz@med.umich.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, USA. mfranz@med.umich.edu","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010817353","display_name":"Wyatt G. Payne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wyatt G Payne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110114635","display_name":"Liyu Xing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liyu Xing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066227230","display_name":"Dama Kondaiah Naidu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D K Naidu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027532020","display_name":"Rico Salas","orcid":"https://orcid.org/0000-0002-4692-8416","observed_orcids":["https://orcid.org/0000-0002-4692-8416"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R E Salas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109869056","display_name":"Vivienne S. Marshall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vivienne S Marshall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026032801","display_name":"Cathy Trumpower","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C J Trumpower","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111977149","display_name":"Charlotte A. Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charlotte A Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044094233","display_name":"David L. Steed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David L Steed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113587116","display_name":"Martin C. Robson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M C Robson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6509,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.91609589,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":null,"first_page":"e21","last_page":"e21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8159999847412109},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.7549999952316284},{"id":"https://openalex.org/keywords/acute-wounds","display_name":"acute wounds","score":0.7960000038146973},{"id":"https://openalex.org/keywords/incisional-hernia","display_name":"incisional hernia","score":0.8579999804496765},{"id":"https://openalex.org/keywords/tissue-inhibitors-of-metalloproteinases","display_name":"tissue inhibitors of metalloproteinases","score":0.8569999933242798},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.7020000219345093},{"id":"https://openalex.org/keywords/escherichia-coli-infection","display_name":"Escherichia coli infection","score":0.8050000071525574},{"id":"https://openalex.org/keywords/burn-wound-infection","display_name":"burn wound infection","score":0.5809999704360962},{"id":"https://openalex.org/keywords/wound-closure","display_name":"wound closure","score":0.6240000128746033},{"id":"https://openalex.org/keywords/breaking-strength","display_name":"breaking strength","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8070518970489502},{"id":"https://openalex.org/C2780646683","wikidata":"https://www.wikidata.org/wiki/Q473749","display_name":"Amnion","level":4,"score":0.7606726884841919},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6397973895072937},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.6167987585067749},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5837380290031433},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.40783631801605225},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39016199111938477},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.35517796874046326},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2507054805755615},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.10178971290588379},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09574133157730103},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmid:18470282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18470282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eplasty","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2323202","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2323202/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eplasty","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.281.6483","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.281.6483","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/55/e6/Eplasty_2008_Apr_11_8_e21.tar.gz","raw_type":"text"},{"id":"mag:24184972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18470282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2323202","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2323202/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eplasty","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1492082915","https://openalex.org/W1508203333","https://openalex.org/W1562423105","https://openalex.org/W1585318094","https://openalex.org/W1911029663","https://openalex.org/W1921809757","https://openalex.org/W1930097530","https://openalex.org/W1966266254","https://openalex.org/W1971176522","https://openalex.org/W1974625077","https://openalex.org/W1979068808","https://openalex.org/W1979855662","https://openalex.org/W1984053802","https://openalex.org/W1989891384","https://openalex.org/W1995105508","https://openalex.org/W1999831372","https://openalex.org/W2000381516","https://openalex.org/W2004392978","https://openalex.org/W2004456850","https://openalex.org/W2005036868","https://openalex.org/W2010540137","https://openalex.org/W2014669733","https://openalex.org/W2015328333","https://openalex.org/W2015524556","https://openalex.org/W2021630037","https://openalex.org/W2022064821","https://openalex.org/W2023218857","https://openalex.org/W2029823248","https://openalex.org/W2033130827","https://openalex.org/W2035346960","https://openalex.org/W2038120157","https://openalex.org/W2039379153","https://openalex.org/W2040827479","https://openalex.org/W2045711626","https://openalex.org/W2045879719","https://openalex.org/W2046655679","https://openalex.org/W2051682990","https://openalex.org/W2055474914","https://openalex.org/W2061015740","https://openalex.org/W2062062519","https://openalex.org/W2064046604","https://openalex.org/W2067918348","https://openalex.org/W2068729659","https://openalex.org/W2071534864","https://openalex.org/W2090263748","https://openalex.org/W2090757807","https://openalex.org/W2091643194","https://openalex.org/W2118124054","https://openalex.org/W2127931233","https://openalex.org/W2128087994","https://openalex.org/W2131117209","https://openalex.org/W2135035484","https://openalex.org/W2135656436","https://openalex.org/W2139116898","https://openalex.org/W2142630775","https://openalex.org/W2145489645","https://openalex.org/W2145820173","https://openalex.org/W2154170543","https://openalex.org/W2158233796","https://openalex.org/W2166798417","https://openalex.org/W2167532631","https://openalex.org/W2171425841","https://openalex.org/W2183242961"],"related_works":["https://openalex.org/W1562423105","https://openalex.org/W1585318094","https://openalex.org/W2133629489","https://openalex.org/W1911029663","https://openalex.org/W4388770828","https://openalex.org/W1987342651","https://openalex.org/W7097671980","https://openalex.org/W4309693234","https://openalex.org/W2022826528","https://openalex.org/W1562279196"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Growth":[1],"factors":[2,17],"demonstrate":[3],"mixed":[4],"results":[5],"improving":[6],"wound":[7,33,169,201],"healing.":[8,34],"Amnion-derived":[9],"multipotent":[10,247],"cells":[11],"release":[12],"physiologic":[13,221],"levels":[14],"of":[15,21,29,63,154,200,223,228,234],"growth":[16],"and":[18,31,119,125,136,171,181,185,225,236],"tissue":[19,226],"inhibitors":[20,227],"metalloproteinases.":[22],"This":[23],"solution":[24,222],"was":[25,46,66,75,175,203],"tested":[26,67],"in":[27,88,157,177,187,205,232],"models":[28,233],"acute":[30,235],"chronic":[32,210,237],"METHODS:":[35],"Acute":[36,142,168],"model:":[37,81,143,197],"Sprague-Dawley":[38],"rats":[39,89],"underwent":[40],"laparotomy":[41,64,155],"incisions.":[42],"The":[43,198],"midline":[44],"fascia":[45],"primed":[47],"with":[48,68,97,104,145,159],"phosphate-buffered":[49,160,179],"saline,":[50],"unconditioned":[51,105,163,182],"media,":[52],"or":[53,107,122,162],"amnion-derived":[54,108,146,189,206,246],"cellular":[55,109,147,190,207],"cytokine":[56,110,148,191,208],"suspension":[57,149],"prior":[58],"to":[59],"incision.":[60],"Breaking":[61],"strength":[62,153],"wounds":[65,85,101,211],"an":[69],"Instron":[70],"tensiometer.":[71],"Incisional":[72],"hernia":[73,173],"formation":[74,174],"measured":[76],"after":[77],"28":[78],"days.":[79],"Chronic":[80,196],"Chronic,":[82],"infected":[83],"granulating":[84],"were":[86,102,113,131],"produced":[87,244],"by":[90],"excising":[91],"full":[92],"thickness":[93],"burn":[94],"eschars":[95],"inoculated":[96],"Escherica":[98],"coli.":[99],"Granulating":[100],"treated":[103],"media":[106,164,183],"suspension.":[111],"Treatments":[112],"applied":[114],"either":[115],"on":[116],"day":[117,120,123],"0":[118,124],"7":[121],"then":[126],"every":[127,133],"other":[128],"day.":[129],"Wounds":[130],"traced":[132],"72":[134],"hours":[135],"biopsied":[137],"for":[138],"quantitative":[139],"bacteriology.":[140],"RESULTS:":[141],"Priming":[144],"increased":[150],"the":[151,178,188,217],"breaking":[152],"incisions":[156],"comparison":[158],"saline":[161,180],"(P":[165,194,212],"<":[166,213],".05).":[167,214],"failure":[170],"incisional":[172],"100%":[176],"groups":[184],"18%":[186],"suspension-treated":[192,209],"group":[193],"<.05).":[195],"rate":[199],"closure":[202],"accelerated":[204],"Multidosing":[215],"improved":[216],"effect.":[218],"CONCLUSIONS:":[219],"A":[220],"cytokines":[224],"metalloproteinases":[229],"improves":[230],"healing":[231],"wounds.":[238],"Such":[239],"a":[240],"cocktail":[241],"can":[242],"be":[243],"from":[245],"progenitor":[248],"cells.":[249]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
