{"id":"https://openalex.org/W2418344628","doi":"https://doi.org/10.1152/jn.1999.82.6.3594","title":"Induction of NMDA Receptor-Dependent Long-Term Depression in Visual Cortex Does Not Require Metabotropic Glutamate Receptors","display_name":"Induction of NMDA Receptor-Dependent Long-Term Depression in Visual Cortex Does Not Require Metabotropic Glutamate Receptors","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W2418344628","doi":"https://doi.org/10.1152/jn.1999.82.6.3594","mag":"2418344628","pmid":"https://pubmed.ncbi.nlm.nih.gov/10601487"},"language":"en","primary_location":{"id":"doi:10.1152/jn.1999.82.6.3594","doi":"https://doi.org/10.1152/jn.1999.82.6.3594","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.1999.82.6.3594","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045684393","display_name":"Nathaniel B. Sawtell","orcid":"https://orcid.org/0000-0002-1859-8026","observed_orcids":["https://orcid.org/0000-0002-1859-8026"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel B. Sawtell","raw_affiliation_strings":["Department of Neuroscience, Howard Hughes Medical Institute, Brown University, Providence, Rhode Island 02912; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Howard Hughes Medical Institute, Brown University, Providence, Rhode Island 02912; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038698200","display_name":"Kimberly M. Huber","orcid":"https://orcid.org/0000-0002-7479-0661","observed_orcids":["https://orcid.org/0000-0002-7479-0661"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly M. Huber","raw_affiliation_strings":["Department of Neuroscience, Howard Hughes Medical Institute, Brown University, Providence, Rhode Island 02912; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Howard Hughes Medical Institute, Brown University, Providence, Rhode Island 02912; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111715744","display_name":"John Roder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John C. Roder","raw_affiliation_strings":["Program in Developmental and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5 and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Developmental and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5 and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I185261750","https://openalex.org/I210557978"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026004510","display_name":"Mark F. Bear","orcid":"https://orcid.org/0000-0002-9903-2541","observed_orcids":["https://orcid.org/0000-0002-9903-2541"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark F. Bear","raw_affiliation_strings":["Department of Neuroscience, Howard Hughes Medical Institute, Brown University, Providence, Rhode Island 02912; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Howard Hughes Medical Institute, Brown University, Providence, Rhode Island 02912; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I27804330"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8435,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.68809809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"82","issue":"6","first_page":"3594","last_page":"3597"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-term-depression","display_name":"long-term depression","score":0.9369999766349792},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.8880000114440918},{"id":"https://openalex.org/keywords/metabotropic-glutamate-receptors","display_name":"metabotropic glutamate receptors","score":0.9559999704360962},{"id":"https://openalex.org/keywords/group-i-mglurs","display_name":"group I mGluRs","score":0.8970000147819519},{"id":"https://openalex.org/keywords/mglur5","display_name":"mGluR5","score":0.9139999747276306},{"id":"https://openalex.org/keywords/ly341495","display_name":"LY341495","score":0.9729999899864197},{"id":"https://openalex.org/keywords/phosphoinositide-hydrolysis","display_name":"phosphoinositide hydrolysis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/visual-cortex","display_name":"visual cortex","score":0.828000009059906},{"id":"https://openalex.org/keywords/synaptic-transmission","display_name":"synaptic transmission","score":0.8510000109672546},{"id":"https://openalex.org/keywords/acpd","display_name":"ACPD","score":0.703000009059906},{"id":"https://openalex.org/keywords/low-frequency-stimulation","display_name":"low-frequency stimulation","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.859728991985321},{"id":"https://openalex.org/C73009533","wikidata":"https://www.wikidata.org/wiki/Q1517140","display_name":"Long-term depression","level":5,"score":0.786806583404541},{"id":"https://openalex.org/C41653306","wikidata":"https://www.wikidata.org/wiki/Q6589190","display_name":"Metabotropic glutamate receptor 5","level":5,"score":0.7553826570510864},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7014575004577637},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.6630445122718811},{"id":"https://openalex.org/C207951395","wikidata":"https://www.wikidata.org/wiki/Q288431","display_name":"Metabotropic glutamate receptor 1","level":5,"score":0.5029663443565369},{"id":"https://openalex.org/C2779345533","wikidata":"https://www.wikidata.org/wiki/Q75785","display_name":"Visual cortex","level":2,"score":0.4786982834339142},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.44937023520469666},{"id":"https://openalex.org/C87247309","wikidata":"https://www.wikidata.org/wiki/Q6590338","display_name":"Metabotropic glutamate receptor 7","level":5,"score":0.4346255660057068},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4210795760154724},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.4127481281757355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39484477043151855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3514719009399414},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29613161087036133},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1552453637123108},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.11020508408546448}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003515","descriptor_name":"Cycloleucine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003515","descriptor_name":"Cycloleucine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008734","descriptor_name":"Methoxyhydroxyphenylglycol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D008734","descriptor_name":"Methoxyhydroxyphenylglycol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013574","descriptor_name":"Synaptosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013574","descriptor_name":"Synaptosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014966","descriptor_name":"Xanthenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/jn.1999.82.6.3594","doi":"https://doi.org/10.1152/jn.1999.82.6.3594","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.1999.82.6.3594","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},{"id":"pmid:10601487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10601487","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurophysiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1527744054","https://openalex.org/W1557451274","https://openalex.org/W1627298799","https://openalex.org/W1993587494","https://openalex.org/W2017615879","https://openalex.org/W2024910408","https://openalex.org/W2029542833","https://openalex.org/W2030854164","https://openalex.org/W2035251383","https://openalex.org/W2036701703","https://openalex.org/W2050027515","https://openalex.org/W2054857167","https://openalex.org/W2067317040","https://openalex.org/W2072818925","https://openalex.org/W2081831423","https://openalex.org/W2088559138","https://openalex.org/W2110298861","https://openalex.org/W2145936933","https://openalex.org/W2157055126","https://openalex.org/W2161584310","https://openalex.org/W2183530574"],"related_works":["https://openalex.org/W2065229967","https://openalex.org/W2017615879","https://openalex.org/W2056031247","https://openalex.org/W2065441266","https://openalex.org/W1975792804","https://openalex.org/W2089418632","https://openalex.org/W1980884616","https://openalex.org/W2233543443","https://openalex.org/W1991575631","https://openalex.org/W7100991393"],"abstract_inverted_index":{"We":[0,38],"tested":[1],"the":[2,9,16,20,29,35,59,62,82,110,117],"role":[3],"of":[4,11,46,61,84,112],"group":[5,102],"I":[6,103],"mGluRs":[7],"in":[8,15,34,50,72,116],"induction":[10,83,111],"long-term":[12],"depression":[13],"(LTD)":[14],"visual":[17,36,51,73,118],"cortex,":[18],"using":[19],"novel":[21],"mGluR":[22,33,63,104],"antagonist":[23],"LY341495":[24,41,77],"and":[25,54],"mice":[26,90],"lacking":[27,91],"mGluR5,":[28],"predominant":[30],"phosphoinositide":[31],"(PI)-linked":[32],"cortex.":[37,119],"find":[39],"that":[40,55,101],"is":[42,106],"a":[43],"potent":[44],"blocker":[45],"glutamate-stimulated":[47],"PI":[48],"hydrolysis":[49],"cortical":[52,74],"synaptoneurosomes,":[53],"it":[56],"effectively":[57],"antagonizes":[58],"actions":[60],"agonist":[64],"1S,":[65],"3R-aminocyclopentane-1,3-dicarboxylic":[66],"acid":[67],"(ACPD)":[68],"on":[69,81],"synaptic":[70],"transmission":[71],"slices.":[75],"However,":[76],"has":[78],"no":[79],"effect":[80],"LTD":[85,115],"by":[86],"low-frequency":[87],"stimulation.":[88],"Furthermore,":[89],"mGluR5":[92],"show":[93],"normal":[94],"NMDA":[95,113],"receptor-dependent":[96,114],"LTD.":[97],"These":[98],"results":[99],"indicate":[100],"activation":[105],"not":[107],"required":[108],"for":[109]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
