{"id":"https://openalex.org/W2418148232","doi":null,"title":"Prediction of early relapse after pimozide discontinuation by response to d-amphetamine during pimozide treatment.","display_name":"Prediction of early relapse after pimozide discontinuation by response to d-amphetamine during pimozide treatment.","publication_year":1982,"publication_date":"1982-02-01","ids":{"openalex":"https://openalex.org/W2418148232","mag":"2418148232","pmid":"https://pubmed.ncbi.nlm.nih.gov/7074181"},"language":"en","primary_location":{"id":"pmid:7074181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7074181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological psychiatry","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031213780","display_name":"Dani\u00ebl P. van Kammen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D P van Kammen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029265257","display_name":"J P Docherty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Docherty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054827230","display_name":"William E. Bunney","orcid":"https://orcid.org/0000-0002-4166-0836","observed_orcids":["https://orcid.org/0000-0002-4166-0836"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W E Bunney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7797,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.93666667,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"17","issue":"2","first_page":"233","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12308","display_name":"Mental Health and Psychiatry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1211","display_name":"Philosophy"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pimozide","display_name":"pimozide","score":0.9520000219345093},{"id":"https://openalex.org/keywords/d-amphetamine","display_name":"d-amphetamine","score":0.6359999775886536},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.7839999794960022},{"id":"https://openalex.org/keywords/recurrence-prediction","display_name":"recurrence prediction","score":0.9279999732971191},{"id":"https://openalex.org/keywords/antipsychotic-discontinuation","display_name":"antipsychotic discontinuation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/dopamine-receptor-blockade","display_name":"dopamine receptor blockade","score":0.5450000166893005},{"id":"https://openalex.org/keywords/psychosis-exacerbation","display_name":"psychosis exacerbation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/neuroleptic-withdrawal","display_name":"neuroleptic withdrawal","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C2777845345","wikidata":"https://www.wikidata.org/wiki/Q144085","display_name":"Pimozide","level":4,"score":0.9830783605575562},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8407150506973267},{"id":"https://openalex.org/C2777193897","wikidata":"https://www.wikidata.org/wiki/Q179452","display_name":"Amphetamine","level":3,"score":0.7145364284515381},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.5700387358665466},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.49817752838134766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4645051658153534},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4231686592102051},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.42024660110473633},{"id":"https://openalex.org/C2780211496","wikidata":"https://www.wikidata.org/wiki/Q411188","display_name":"Aripiprazole","level":3,"score":0.4152938723564148},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3670198917388916},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.3471834063529968},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.30498892068862915},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2746174931526184},{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.2526013255119324}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003913","descriptor_name":"Dextroamphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010868","descriptor_name":"Pimozide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010868","descriptor_name":"Pimozide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012565","descriptor_name":"Schizophrenic Psychology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7074181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7074181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological psychiatry","raw_type":"Journal Article"},{"id":"mag:2418148232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7074181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1963645898","https://openalex.org/W105702944","https://openalex.org/W1991911381","https://openalex.org/W2058729991","https://openalex.org/W167852875","https://openalex.org/W2033450926","https://openalex.org/W112532169","https://openalex.org/W2417593127","https://openalex.org/W2415517016","https://openalex.org/W2424143217"],"abstract_inverted_index":{"Thirteen":[0],"schizophrenic":[1,125],"patients":[2,23,43,95,126],"underwent":[3],"a":[4,16,104],"d-amphetamine":[5,32,71,92,110],"infusion":[6,111],"while":[7],"being":[8],"treated":[9],"with":[10,31,50],"pimozide,":[11],"an":[12,26],"antipsychotic":[13],"agent":[14],"and":[15],"relatively":[17],"specific":[18],"dopamine":[19],"(DA)":[20],"blocker.":[21],"Six":[22],"who":[24,44],"showed":[25],"acute":[27],"increase":[28],"in":[29,48,93,106],"psychosis":[30,49],"relapsed":[33],"within":[34],"3":[35],"months":[36],"after":[37,56,132],"pimozide":[38,57,82],"withdrawal.":[39,83],"Of":[40],"the":[41,67,88],"seven":[42],"did":[45,53],"not":[46,54],"change":[47],"d-amphetamine,":[51],"six":[52,94],"relapse":[55,131],"discontinuation":[58,133],"(Fisher's":[59],"exact":[60],"test,":[61],"p":[62],"less":[63],"than":[64],"0.005).":[65],"Retrospectively,":[66],"psychosis-inducing":[68],"effects":[69,90],"of":[70,77,91,134],"were":[72],"found":[73],"to":[74,86,117],"be":[75,114],"predictive":[76],"psychotic":[78,107],"exacerbation":[79],"following":[80],"subsequent":[81],"Pimozide":[84],"failed":[85],"block":[87],"psychotogenic":[89],"indicating":[96],"that":[97],"other":[98],"mechanisms":[99],"besides":[100],"DA":[101],"may":[102],"play":[103],"role":[105],"decompensation.":[108],"The":[109],"paradigm":[112],"should":[113],"studied":[115],"further":[116],"determine":[118],"its":[119],"clinical":[120],"value":[121],"for":[122,130],"identifying":[123],"which":[124],"are":[127],"at":[128],"risk":[129],"neuroleptic":[135],"treatment.":[136]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
