{"id":"https://openalex.org/W2418079271","doi":null,"title":"JAK INHIBITOR CLINICAL RESPONSE IN POLYARTHRITIS: CASE REPORT.","display_name":"JAK INHIBITOR CLINICAL RESPONSE IN POLYARTHRITIS: CASE REPORT.","publication_year":2015,"publication_date":"2015-06-01","ids":{"openalex":"https://openalex.org/W2418079271","mag":"2418079271","pmid":"https://pubmed.ncbi.nlm.nih.gov/26415324"},"language":"en","primary_location":{"id":"pmid:26415324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26415324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta clinica Croatica","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hrcak.srce.hr/file/214515","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033250867","display_name":"Asja Stipi\u0107-Markovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086219","display_name":"Klini\u010dka bolnica \"Sveti Duh\"","ror":"https://ror.org/00t8kk495","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210086219"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Asja Stipi\u0107-Markovi\u0107","raw_affiliation_strings":["Department of Clinical Immunology, Pulmonology and Rheumatology, Sveti Duh University Hospital, Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology, Pulmonology and Rheumatology, Sveti Duh University Hospital, Zagreb, Croatia","institution_ids":["https://openalex.org/I4210086219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064573196","display_name":"Iva Fer\u010dek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iva Fer\u010dek","raw_affiliation_strings":["Health Care Center of Zagreb County, Samobor; Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Care Center of Zagreb County, Samobor; Croatia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049817504","display_name":"Marta \u010cubela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405262539","display_name":"Op\u0107a \u017eupanijska bolnica Po\u017eega","ror":"https://ror.org/03x53pw92","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4405262539"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Marta \u010cubela","raw_affiliation_strings":["Po\u017eega General County Hospital, Po\u017eega, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Po\u017eega General County Hospital, Po\u017eega, Croatia","institution_ids":["https://openalex.org/I4405262539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014072384","display_name":"Marinko Artukovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086219","display_name":"Klini\u010dka bolnica \"Sveti Duh\"","ror":"https://ror.org/00t8kk495","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210086219"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Marinko Artukovi\u0107","raw_affiliation_strings":["Department of Clinical Immunology, Pulmonology and Rheumatology, Sveti Duh University Hospital, Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology, Pulmonology and Rheumatology, Sveti Duh University Hospital, Zagreb, Croatia","institution_ids":["https://openalex.org/I4210086219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079387253","display_name":"Ksenija Ma\u0161trovi\u0107 Radon\u010di\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086219","display_name":"Klini\u010dka bolnica \"Sveti Duh\"","ror":"https://ror.org/00t8kk495","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210086219"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Ksenija Ma\u0161trovi\u0107 Radon\u010di\u0107","raw_affiliation_strings":["Department of Rheumatology, Physical and Rehabilitation Medicine, Sveti Duh University Hospital, Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Physical and Rehabilitation Medicine, Sveti Duh University Hospital, Zagreb, Croatia","institution_ids":["https://openalex.org/I4210086219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018675547","display_name":"Liborija Lugovi\u0107\u2010Mihi\u0107","orcid":"https://orcid.org/0000-0001-7494-5742","observed_orcids":["https://orcid.org/0000-0001-7494-5742"]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]},{"id":"https://openalex.org/I4210123681","display_name":"Sisters of Charity Hospital","ror":"https://ror.org/024a8dx81","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210123681"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Liborija Lugovi\u0107-Mihi\u0107","raw_affiliation_strings":["Clinical Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia","institution_ids":["https://openalex.org/I138937732","https://openalex.org/I4210123681"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"54","issue":"2","first_page":"236","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/jak-inhibitors","display_name":"JAK inhibitors","score":0.6990000009536743},{"id":"https://openalex.org/keywords/seronegative-rheumatoid-arthritis","display_name":"seronegative rheumatoid arthritis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/early-rheumatoid-arthritis","display_name":"early rheumatoid arthritis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/polyarthritis","display_name":"polyarthritis","score":0.597000002861023},{"id":"https://openalex.org/keywords/targeted-synthetic-dmards","display_name":"targeted synthetic DMARDs","score":0.6919999718666077},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.7960000038146973},{"id":"https://openalex.org/keywords/leflunomide","display_name":"leflunomide","score":0.9810000061988831},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.6790000200271606},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.6269999742507935},{"id":"https://openalex.org/keywords/functional-capacity","display_name":"functional capacity","score":0.48500001430511475},{"id":"https://openalex.org/keywords/immunomodulators","display_name":"immunomodulators","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8969334363937378},{"id":"https://openalex.org/C2775905006","wikidata":"https://www.wikidata.org/wiki/Q248550","display_name":"Leflunomide","level":3,"score":0.741254448890686},{"id":"https://openalex.org/C2778917330","wikidata":"https://www.wikidata.org/wiki/Q1274464","display_name":"Polyarthritis","level":3,"score":0.7194535136222839},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.6556754112243652},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6510130167007446},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6309758424758911},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.486505925655365},{"id":"https://openalex.org/C2779244835","wikidata":"https://www.wikidata.org/wiki/Q538432","display_name":"Synovitis","level":3,"score":0.4642990231513977},{"id":"https://openalex.org/C2777489490","wikidata":"https://www.wikidata.org/wiki/Q684924","display_name":"Rheumatism","level":2,"score":0.4529416263103485},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.45027321577072144},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4465300738811493},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.44189080595970154},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.41280221939086914}],"mesh":[{"descriptor_ui":"D001168","descriptor_name":"Arthritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001168","descriptor_name":"Arthritis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D053612","descriptor_name":"Janus Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D053612","descriptor_name":"Janus Kinases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:26415324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26415324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta clinica Croatica","raw_type":"Case Reports"},{"id":"pmh:oai:hrcak.srce.hr:145617","doi":null,"is_oa":true,"landing_page_url":"http://hrcak.srce.hr/145617","pdf_url":"http://hrcak.srce.hr/file/214515","source":{"id":"https://openalex.org/S4306400071","display_name":"University of Zagreb University Computing Centre (SRCE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181343428","host_organization_name":"University of Zagreb","host_organization_lineage":["https://openalex.org/I181343428"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta clinica Croatica","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:35f41da623d04fce8bde767ffb64082f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/35f41da623d04fce8bde767ffb64082f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Clinica Croatica, Vol 54., Iss 2., Pp 236-241 (2015)","raw_type":"article"},{"id":"mag:2418079271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26415324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:hrcak.srce.hr:145617","doi":null,"is_oa":true,"landing_page_url":"http://hrcak.srce.hr/145617","pdf_url":"http://hrcak.srce.hr/file/214515","source":{"id":"https://openalex.org/S4306400071","display_name":"University of Zagreb University Computing Centre (SRCE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181343428","host_organization_name":"University of Zagreb","host_organization_lineage":["https://openalex.org/I181343428"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta clinica Croatica","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2418079271.pdf","grobid_xml":"https://content.openalex.org/works/W2418079271.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1864496754","https://openalex.org/W1925780210","https://openalex.org/W1972556280","https://openalex.org/W1979232932","https://openalex.org/W2009831896","https://openalex.org/W2016247525","https://openalex.org/W2032636269","https://openalex.org/W2049220563","https://openalex.org/W2054464764","https://openalex.org/W2061785558","https://openalex.org/W2101005621","https://openalex.org/W2104086317","https://openalex.org/W2104481491","https://openalex.org/W2109237866","https://openalex.org/W2110826367","https://openalex.org/W2114768841","https://openalex.org/W2117926449","https://openalex.org/W2128952811","https://openalex.org/W2130941135","https://openalex.org/W2134171514","https://openalex.org/W2144560150","https://openalex.org/W2147040876","https://openalex.org/W2150030906","https://openalex.org/W2168711455","https://openalex.org/W2170075029"],"related_works":["https://openalex.org/W4399319819","https://openalex.org/W4320301686","https://openalex.org/W2156702151","https://openalex.org/W3045637119","https://openalex.org/W2995162807","https://openalex.org/W4299888873","https://openalex.org/W4414082120","https://openalex.org/W3012453836","https://openalex.org/W3198905869","https://openalex.org/W4281631753"],"abstract_inverted_index":{"The":[0,134,252],"heterogeneity":[1],"of":[2,10,18,31,73,95,119,126,157,173,188,206,224,267,273,294,297],"rheumatoid":[3],"arthritis":[4],"(RA)":[5],"presentation":[6],"and":[7,38,77,80,89,115,129,176,195,199,232],"molecular":[8],"signature":[9],"RA":[11,167],"subclasses":[12],"in":[13,56,196,240,282,299],"patients":[14],"with":[15,60,203,215],"early":[16,124],"changes":[17],"small":[19],"peripheral":[20],"joints":[21],"still":[22],"remains":[23],"a":[24,93,96,146,216,229,254,292],"challenging":[25],"problem.":[26],"In":[27],"clinical":[28,186],"setting,":[29],"classification":[30],"the":[32,44,57,61,71,151,161,174,189,204,222,233,244,268,271,300],"disease":[33,50],"subtypes":[34],"is":[35,41,228],"not":[36,142,178,236],"possible":[37],"treatment":[39,58,302],"adjustment":[40],"based":[42,168],"on":[43,169],"continuous":[45],"Disease":[46],"Activity":[47],"Score":[48],"for":[49,145,259],"severity":[51],"recognition.":[52],"A":[53,184],"new":[54,249],"approach":[55],"appears":[59],"novel":[62],"non":[63],"biologic":[64],"targeted":[65,219],"synthetic":[66],"disease-modifying":[67],"antirheumatic":[68],"drugs":[69],"from":[70,102,104],"group":[72],"Janus":[74],"kinase":[75],"1":[76],"3":[78],"(JAKI":[79],"JAK3),":[81],"blocking":[82],"interleukin":[83],"(IL)-2,":[84],"IL-4,":[85],"IL-7,":[86],"IL-9,":[87],"IL-15":[88],"IL-21.":[90],"We":[91],"report":[92],"case":[94],"48-year-old":[97],"patient":[98,135,162],"who":[99],"had":[100],"suffered":[101],"polyarthritis":[103,301],"his":[105,283],"age":[106],"40.":[107],"Initial":[108],"laboratory":[109],"tests":[110],"showed":[111],"low":[112],"inflammatory":[113],"parameters":[114],"magnetic":[116],"resonance":[117],"imaging":[118],"both":[120],"hands":[121],"indicated":[122],"an":[123],"stage":[125],"RA.":[127],"Methylprednisolone":[128],"methotrexate":[130,198],"therapy":[131,191],"was":[132,141,163,201,212,257,286],"initiated.":[133],"underwent":[136],"additional":[137],"tests,":[138],"but":[139,209],"there":[140],"sufficient":[143],"evidence":[144],"precise":[147],"diagnosis.":[148],"According":[149],"to":[150,246,264],"European":[152],"League":[153],"Against":[154],"Rheumatism/American":[155],"College":[156],"Rheumatology":[158],"score-based":[159],"algorithm,":[160],"classified":[164],"as":[165,193],"seronegative":[166],"joint":[170],"involvement,":[171],"duration":[172],"disease,":[175,269],"synovitis":[177],"better":[179],"explained":[180],"by":[181],"another":[182],"disease.":[183],"partial":[185],"effect":[187],"administered":[190],"(steroids":[192],"monotherapy":[194],"combination,":[197],"leflunomide)":[200],"noticed":[202],"use":[205,223],"systemic":[207],"steroids,":[208],"dramatic":[210],"improvement":[211],"only":[213],"achieved":[214],"JAK":[217],"inhibitor":[218],"therapy.":[220,277],"Although":[221],"anti":[225],"TNF-\u03b1":[226],"blocker":[227],"proposed":[230],"procedure":[231],"drug":[234],"has":[235],"yet":[237],"been":[238],"registered":[239],"Europe,":[241],"we":[242],"took":[243],"opportunity":[245],"apply":[247],"this":[248],"medication":[250],"option.":[251],"patient,":[253],"construction":[255],"worker,":[256],"treated":[258],"20":[260],"months,":[261],"which":[262],"led":[263],"complete":[265],"remission":[266],"without":[270],"need":[272],"basic":[274],"or":[275],"corticosteroid":[276],"Full":[278],"functional":[279],"capacity":[280],"necessary":[281],"demanding":[284],"job":[285],"also":[287],"achieved.":[288],"This":[289],"result":[290],"raised":[291],"question":[293],"timely":[295],"introduction":[296],"immunomodulators":[298],"steps.":[303]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}