{"id":"https://openalex.org/W2417982011","doi":null,"title":"[Enhanced immune response of a novel T-cell immunogen in vaccine for foot-and-mouth disease].","display_name":"[Enhanced immune response of a novel T-cell immunogen in vaccine for foot-and-mouth disease].","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W2417982011","mag":"2417982011","pmid":"https://pubmed.ncbi.nlm.nih.gov/22117511"},"language":"zh","primary_location":{"id":"pmid:22117511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22117511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037730876","display_name":"Qing Zhao","orcid":"https://orcid.org/0000-0003-2744-1239","observed_orcids":["https://orcid.org/0000-0003-2744-1239"]},"institutions":[{"id":"https://openalex.org/I4210090981","display_name":"Lanzhou Veterinary Research Institute","ror":"https://ror.org/00dg3j745","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210090981","https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Zhao","raw_affiliation_strings":["National Foot-and-Mouth Disease Reference Laboratory of China, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Foot-and-Mouth Disease Reference Laboratory of China, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China","institution_ids":["https://openalex.org/I4210090981","https://openalex.org/I4210138501"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pu Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pu Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063917782","display_name":"Zaixin Liu","orcid":"https://orcid.org/0009-0008-9987-386X","observed_orcids":["https://orcid.org/0009-0008-9987-386X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zaixin Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070589231","display_name":"Pinghua Li","orcid":"https://orcid.org/0000-0003-4314-7400","observed_orcids":["https://orcid.org/0000-0003-4314-7400"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pinghua Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111769408","display_name":"Huifang Bao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huifang Bao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043030184","display_name":"Yimei Cao","orcid":"https://orcid.org/0009-0000-1267-9741","observed_orcids":["https://orcid.org/0009-0000-1267-9741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yimei Cao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014992075","display_name":"Xingwen Bai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xingwen Bai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022226638","display_name":"Yuanfang Fu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuanfang Fu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109512240","display_name":"Zengjun Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zengjun Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101758402","display_name":"Dong Li","orcid":"https://orcid.org/0000-0002-9101-0241","observed_orcids":["https://orcid.org/0000-0002-9101-0241"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dong Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44137539,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"9","first_page":"1281","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foot-and-mouth-disease","display_name":"foot-and-mouth disease","score":0.8730000257492065},{"id":"https://openalex.org/keywords/foot-and-mouth-disease-virus","display_name":"foot-and-mouth disease virus","score":0.8579999804496765},{"id":"https://openalex.org/keywords/t-cell-epitopes","display_name":"T cell epitopes","score":0.7850000262260437},{"id":"https://openalex.org/keywords/vp1","display_name":"VP1","score":0.8420000076293945},{"id":"https://openalex.org/keywords/vp4-protein","display_name":"VP4 protein","score":0.6869999766349792},{"id":"https://openalex.org/keywords/recombinant-fusion-protein","display_name":"recombinant fusion protein","score":0.878000020980835},{"id":"https://openalex.org/keywords/inactivated-vaccine","display_name":"inactivated vaccine","score":0.953000009059906},{"id":"https://openalex.org/keywords/protein-subunit-vaccines","display_name":"subunit vaccine","score":0.9039999842643738},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.9350000023841858},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8640000224113464},{"id":"https://openalex.org/keywords/humoral-and-cellular-immunity","display_name":"humoral and cellular immunity","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C2779909307","wikidata":"https://www.wikidata.org/wiki/Q1660181","display_name":"Immunogen","level":4,"score":0.9972360730171204},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.9153236150741577},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7601690292358398},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6406668424606323},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.619169294834137},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6005988121032715},{"id":"https://openalex.org/C2776151397","wikidata":"https://www.wikidata.org/wiki/Q1911079","display_name":"Foot-and-mouth disease virus","level":3,"score":0.5735135078430176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5525866150856018},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4668391942977905},{"id":"https://openalex.org/C2776872762","wikidata":"https://www.wikidata.org/wiki/Q3560939","display_name":"Inactivated vaccine","level":3,"score":0.44872137904167175},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.42580294609069824},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4109358787536621},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.38420772552490234},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3006603717803955},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.13125672936439514}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005536","descriptor_name":"Foot-and-Mouth Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005536","descriptor_name":"Foot-and-Mouth Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D005536","descriptor_name":"Foot-and-Mouth Disease","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D029544","descriptor_name":"Foot-and-Mouth Disease Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22117511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22117511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology","raw_type":"English Abstract"},{"id":"mag:2417982011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22117511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2100206263","https://openalex.org/W7099231146","https://openalex.org/W7100814250","https://openalex.org/W2371704979","https://openalex.org/W2386163448","https://openalex.org/W2172036084","https://openalex.org/W2474674566","https://openalex.org/W1988891185","https://openalex.org/W2933573917","https://openalex.org/W7095860240"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,30,51,54,90,124,187],"enhanced":[3],"immune":[4,16],"response":[5],"of":[6,37,53,71,113,152,158,189],"a":[7],"recombinant":[8],"T":[9,19,26,141],"cell":[10,20,27,47,142],"immunogen":[11,21,108,168,173],"as":[12],"an":[13,175],"effective":[14,176],"cellular":[15,181],"adjuvant.":[17],"The":[18,93],"named":[22,60],"TI":[23,91,107,167,172],"contained":[24,67],"several":[25],"epitopes":[28],"from":[29],"VP1,":[31],"VP4,":[32],"3A":[33],"and":[34,42,73,148,180,183],"3D":[35],"proteins":[36,70],"foot-and-mouth":[38],"disease":[39],"virus":[40],"(FMDV)":[41],"two":[43,68],"pan-T":[44],"helper":[45],"(T(H))":[46],"sites":[48],"to":[49],"broaden":[50],"immunogenicity":[52,188],"protein.":[55],"Meanwhile,":[56],"another":[57],"fusion":[58],"protein":[59,86,104,133,193],"OA-VP1":[61,85,103,132],"was":[62,174],"expressed":[63],"in":[64,140,155,163],"bacteria,":[65],"which":[66],"VP1":[69],"O":[72],"Asia1":[74],"type":[75],"FMDV.":[76],"Mice":[77],"were":[78,161],"vaccinated":[79],"with":[80,87,99,106,128,166],"commercially":[81],"inactivated":[82,100,129,190],"vaccine":[83,101,130,191],"or":[84,88,102,119,131,192],"without":[89],"immunogen.":[92],"results":[94],"show":[95],"that":[96],"mice":[97,125],"inoculated":[98,127],"supplemented":[105,165],"produced":[109],"significantly":[110,149],"higher":[111,150],"level":[112],"neutralizing":[114],"antibodies":[115],"(P":[116,169],"<":[117,121,170],"0.01":[118],"P":[120],"0.05)":[122],"than":[123],"only":[126],"by":[134,144],"microneutralization":[135],"assay.":[136],"An":[137],"obvious":[138],"increase":[139],"number":[143],"flow":[145],"cytometric":[146],"analysis":[147],"concentration":[151],"IFN-gamma":[153],"secreted":[154],"culture":[156],"media":[157],"spleen":[159],"lymphocytes":[160],"observed":[162],"groups":[164],"0.01).":[171],"stimulator":[177],"for":[178],"humoral":[179],"immunity":[182],"could":[184],"help":[185],"improve":[186],"subunit":[194],"vaccine.":[195]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
