{"id":"https://openalex.org/W2417977971","doi":null,"title":"Amifostine cytoprotection with chemotherapy for advanced ovarian carcinoma.","display_name":"Amifostine cytoprotection with chemotherapy for advanced ovarian carcinoma.","publication_year":1996,"publication_date":"1996-08-01","ids":{"openalex":"https://openalex.org/W2417977971","mag":"2417977971","pmid":"https://pubmed.ncbi.nlm.nih.gov/8783673"},"language":"en","primary_location":{"id":"pmid:8783673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8783673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005911289","display_name":"Peter Graham Rose","orcid":"https://orcid.org/0000-0003-2676-0166","observed_orcids":["https://orcid.org/0000-0003-2676-0166","https://orcid.org/0000-0001-7705-3432"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"P G Rose","raw_affiliation_strings":["Division of Gynecologic Oncology, Department of Reproductive Biology, University Hospitals of Cleveland, Case Western Reserve University, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gynecologic Oncology, Department of Reproductive Biology, University Hospitals of Cleveland, Case Western Reserve University, OH 44106, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005911289"],"corresponding_institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":0.198,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.51972284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"23","issue":"4 Suppl 8","first_page":"83","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amifostine","display_name":"amifostine","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.9319999814033508},{"id":"https://openalex.org/keywords/advanced-ovarian-cancer","display_name":"advanced ovarian cancer","score":0.6930000185966492},{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.871999979019165},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":1.0},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.8550000190734863},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.9039999842643738},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C2779387952","wikidata":"https://www.wikidata.org/wiki/Q251698","display_name":"Amifostine","level":3,"score":0.9689044952392578},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9387757182121277},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.6705646514892578},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.568671703338623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5625715255737305},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.536314070224762},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.528326153755188},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5243352055549622},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5217207670211792},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.4756728708744049},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4373458921909332}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004999","descriptor_name":"Amifostine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004999","descriptor_name":"Amifostine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011292","descriptor_name":"Premedication","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017933","descriptor_name":"Peripheral Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8783673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8783673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Clinical Trial"},{"id":"mag:2417977971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8783673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2168284025","https://openalex.org/W2439248396","https://openalex.org/W2125775222","https://openalex.org/W7101236718","https://openalex.org/W1997915125","https://openalex.org/W2050597069","https://openalex.org/W2017895245","https://openalex.org/W2245111968","https://openalex.org/W3156060554","https://openalex.org/W2465108973"],"abstract_inverted_index":{"To":[0],"determine":[1],"the":[2,10,103,114,191,197,209,215,224,252,284,295,298,310,328,353],"efficacy":[3],"of":[4,15,33,111,116,131,164,170,208,214,227,231,283,302,358],"pretreatment":[5,340],"with":[6,23,41,53,119,125,147,168,341],"amifostine":[7,44,76,148,171,198,216,287,339],"in":[8,19,91,184,190,196,251,276,278,309,327],"diminishing":[9],"hematologic":[11,132,137,155],"and":[12,17,37,67,97,113,138,212,242,280,286,300,319,331,335,344,360],"nonhematologic":[13],"toxicities":[14,337],"cyclophosphamide":[16,34],"cisplatin":[18,38],"previously":[20],"untreated":[21],"patients":[22,52,64,123,166,174,211,219],"stage":[24,54],"III/IV":[25,55],"ovarian":[26,57],"cancer,":[27],"a":[28,274],"multicenter":[29],"randomized":[30,68],"controlled":[31],"trial":[32],"(1,000":[35],"mg/m(2))":[36,46],"(100":[39],"mg/m(2)":[40],"or":[42,75,107,133,156,265],"without":[43],"(910":[45],"was":[47],"performed.":[48],"Two":[49],"hundred":[50],"forty-two":[51],"epithelial":[56],"cancer":[58],"were":[59,65,89,100,186,248,305,322],"enrolled.":[60],"Following":[61],"primary":[62],"surgery,":[63],"stratified":[66],"to":[69,105,194,261,263,267,355],"either":[70],"cyclophosphamide/cisplatin":[71],"(CP;":[72],"120":[73],"patients)":[74,80],"plus":[77,149,172,199,217,288],"CP":[78,126,150,165,173,192,200,210,218,228,285,289],"(122":[79],"every":[81],"3":[82],"weeks":[83],"for":[84,154],"six":[85,139,296],"cycles.":[86],"Patient":[87],"characteristics":[88],"similar":[90],"both":[92],"groups.":[93],"Cytoprotective":[94],"end":[95],"points":[96],"tumor":[98],"response":[99,317,343],"evaluated,":[101],"including":[102],"need":[104],"delay":[106,275],"discontinue":[108],"therapy":[109,129,153],"because":[110,130,230],"toxicity":[112,135,158],"incidence":[115,299],"febrile":[117],"neutropenia":[118,178],"associated":[120],"complications.":[121],"Fourteen":[122],"treated":[124,146],"discontinued":[127,151],"protocol":[128,152],"renal":[134,157],"(eight":[136],"renal).":[140],"In":[141],"contrast,":[142],"only":[143],"one":[144],"patient":[145],"(P":[159,179,202,220,291,313],"<":[160,264],".001).":[161],"Forty-three":[162],"percent":[163,207],"compared":[167],"22%":[169],"had":[175,223],"grade":[176],"4":[177],"=":[180,203,221,266,292,314],".001);":[181],"total":[182],"days":[183],"hospital":[185],"reduced":[187,250,308],"from":[188],"258":[189],"arm":[193,201],"11":[195],".009,":[204],"two-sided).":[205],"Sixty-five":[206],"41%":[213],".004)":[222],"next":[225],"cycle":[226],"delayed":[229],"an":[232],"absolute":[233],"neutrophil":[234],"count":[235],"below":[236],"1,500/microL":[237],"at":[238],"day":[239,271],"22.":[240],"Platelet":[241],"red":[243],"blood":[244],"cell":[245],"transfusion":[246],"support":[247],"substantially":[249],"group":[253,312],"that":[254],"received":[255],"amifostine.":[256],"The":[257,324],"serum":[258],"creatinine":[259],"failed":[260],"return":[262],"1.5":[268],"mg/dL":[269],"by":[270,338],"22,":[272],"requiring":[273],"chemotherapy":[277],"15%":[279],"5%,":[281],"respectively,":[282],"groups":[290],".014).":[293],"Over":[294],"cycles,":[297],"severity":[301],"peripheral":[303],"neuropathy":[304],"also":[306],"significantly":[307],"amifostine-treated":[311],".029).":[315],"Pathologic":[316],"rates":[318],"survival":[320,345],"curves":[321],"equivalent.":[323],"significant":[325],"reduction":[326],"CP-induced":[329],"acute":[330],"cumulative":[332],"hematologic,":[333],"renal,":[334],"neurologic":[336],"equivalent":[342],"indicates":[346],"selective":[347,350],"cytoprotection.":[348],"This":[349],"effect":[351],"has":[352],"potential":[354],"affect":[356],"quality":[357],"life":[359],"medical":[361],"economic":[362],"considerations.":[363]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}