{"id":"https://openalex.org/W2417879879","doi":null,"title":"Hemolysis-free plasma miR-214 as novel biomarker of gastric cancer and is correlated with distant metastasis.","display_name":"Hemolysis-free plasma miR-214 as novel biomarker of gastric cancer and is correlated with distant metastasis.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2417879879","mag":"2417879879","pmid":"https://pubmed.ncbi.nlm.nih.gov/25973319","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4396053"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3389291","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4396053","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4396053","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101489050","display_name":"Kecheng Zhang","orcid":"https://orcid.org/0000-0001-8473-1748","observed_orcids":["https://orcid.org/0000-0001-8473-1748"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke-Cheng Zhang","raw_affiliation_strings":["Department of General Surgery, Chinese People's Liberation Army General Hospital 28 Fuxing Road, Beijing 100853, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Chinese People's Liberation Army General Hospital 28 Fuxing Road, Beijing 100853, China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109358100","display_name":"Hongqing Xi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Qing Xi","raw_affiliation_strings":["Department of General Surgery, Chinese People's Liberation Army General Hospital 28 Fuxing Road, Beijing 100853, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Chinese People's Liberation Army General Hospital 28 Fuxing Road, Beijing 100853, China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023991462","display_name":"Jianxin Cui","orcid":"https://orcid.org/0000-0003-3100-1519","observed_orcids":["https://orcid.org/0000-0003-3100-1519"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Xin Cui","raw_affiliation_strings":["Department of General Surgery, Chinese People's Liberation Army General Hospital 28 Fuxing Road, Beijing 100853, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Chinese People's Liberation Army General Hospital 28 Fuxing Road, Beijing 100853, China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113985455","display_name":"Weisong Shen","orcid":"https://orcid.org/0000-0001-9181-3581","observed_orcids":["https://orcid.org/0000-0001-9181-3581"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei-Song Shen","raw_affiliation_strings":["Department of General Surgery, Chinese People's Liberation Army General Hospital 28 Fuxing Road, Beijing 100853, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Chinese People's Liberation Army General Hospital 28 Fuxing Road, Beijing 100853, China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100784779","display_name":"Jiyang Li","orcid":"https://orcid.org/0000-0003-3731-6714","observed_orcids":["https://orcid.org/0000-0003-3731-6714"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji-Yang Li","raw_affiliation_strings":["Department of General Surgery, Chinese People's Liberation Army General Hospital 28 Fuxing Road, Beijing 100853, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Chinese People's Liberation Army General Hospital 28 Fuxing Road, Beijing 100853, China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014711277","display_name":"Bo Wei","orcid":"https://orcid.org/0000-0001-7386-2689","observed_orcids":["https://orcid.org/0000-0001-7386-2689"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Wei","raw_affiliation_strings":["Department of General Surgery, Chinese People's Liberation Army General Hospital 28 Fuxing Road, Beijing 100853, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Chinese People's Liberation Army General Hospital 28 Fuxing Road, Beijing 100853, China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4210160531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100443684","display_name":"Lin Chen","orcid":"https://orcid.org/0000-0001-6245-8509","observed_orcids":["https://orcid.org/0000-0001-6245-8509","https://orcid.org/0000-0001-7905-2505","https://orcid.org/0000-0002-3507-673X","https://orcid.org/0000-0002-0502-3274","https://orcid.org/0000-0001-6935-1552","https://orcid.org/0000-0002-3957-1869","https://orcid.org/0000-0002-1910-2547","https://orcid.org/0000-0003-2354-3182"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Chen","raw_affiliation_strings":["Department of General Surgery, Chinese People's Liberation Army General Hospital 28 Fuxing Road, Beijing 100853, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Chinese People's Liberation Army General Hospital 28 Fuxing Road, Beijing 100853, China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4210160531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4498,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.78743153,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"2","first_page":"821","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-214","display_name":"miR-214","score":0.9490000009536743},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9150000214576721},{"id":"https://openalex.org/keywords/circulating-micrornas","display_name":"circulating microRNAs","score":0.9440000057220459},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.9319999814033508},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cancer-detection","display_name":"cancer detection","score":0.6539999842643738},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.781000018119812},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.683219313621521},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.6560798287391663},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6497815847396851},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6449244618415833},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6082241535186768},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5425719022750854},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5115216970443726},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49731114506721497},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4755101799964905},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1736150085926056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3389291","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4396053","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25973319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25973319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4396053","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4396053/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"mag:2417879879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25973319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3389291","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4396053","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1482814115","https://openalex.org/W1971924058","https://openalex.org/W1973102533","https://openalex.org/W1981989535","https://openalex.org/W1983932066","https://openalex.org/W1985749891","https://openalex.org/W1995057279","https://openalex.org/W1999589813","https://openalex.org/W2001476170","https://openalex.org/W2005154499","https://openalex.org/W2007103799","https://openalex.org/W2007499410","https://openalex.org/W2012127976","https://openalex.org/W2012511861","https://openalex.org/W2032801250","https://openalex.org/W2033820943","https://openalex.org/W2036727594","https://openalex.org/W2037044064","https://openalex.org/W2047350450","https://openalex.org/W2057419005","https://openalex.org/W2063920927","https://openalex.org/W2066245403","https://openalex.org/W2070859975","https://openalex.org/W2073887351","https://openalex.org/W2075679644","https://openalex.org/W2092913756","https://openalex.org/W2100927341","https://openalex.org/W2103657965","https://openalex.org/W2106787323","https://openalex.org/W2107277218","https://openalex.org/W2111628123","https://openalex.org/W2114570899","https://openalex.org/W2115093090","https://openalex.org/W2126336279","https://openalex.org/W2126914289","https://openalex.org/W2132780337","https://openalex.org/W2133875700","https://openalex.org/W2134747634","https://openalex.org/W2135810600","https://openalex.org/W2139016888","https://openalex.org/W2140775205","https://openalex.org/W2149966907","https://openalex.org/W2159874038","https://openalex.org/W2161068194","https://openalex.org/W2164953784","https://openalex.org/W2168314151","https://openalex.org/W2168996075","https://openalex.org/W2192080449","https://openalex.org/W4231021828"],"related_works":["https://openalex.org/W1976630646","https://openalex.org/W2368594342","https://openalex.org/W2053647756","https://openalex.org/W2800736042","https://openalex.org/W2100614154","https://openalex.org/W2166238934","https://openalex.org/W2168709284","https://openalex.org/W2899370255","https://openalex.org/W2952501714","https://openalex.org/W2105074454"],"abstract_inverted_index":{"Circulating":[0],"miRNAs":[1],"gains":[2],"popularity":[3],"for":[4,30],"its":[5],"potential":[6],"ability":[7],"to":[8,20,38],"serve":[9],"as":[10,27],"biomarkers":[11,29],"of":[12,16,24,61,68,101,109,131,156,182],"cancer.":[13,184],"The":[14],"aim":[15],"present":[17],"study":[18,46,59],"was":[19,85,105,178],"evaluate":[21],"the":[22,152],"usefulness":[23],"plasma":[25,110,160,176],"miR-214":[26,69,84,111,132,161,177],"novel":[28,179],"gastric":[31,183],"cancer":[32],"(GC)":[33],"detection.":[34],"Attempts":[35],"were":[36,70,127],"made":[37],"address":[39],"several":[40],"pitfalls":[41],"in":[42,48,57,73,88,93,133,138],"sample":[43],"processing":[44],"and":[45,64,117],"design":[47],"previous":[49],"studies.":[50],"We":[51],"conducted":[52],"a":[53],"two-step":[54],"analysis:":[55],"(1)":[56],"pilot":[58],"comprising":[60],"30":[62,65],"patients":[63,89,113,136],"controls,":[66],"levels":[67,130],"significantly":[71,86,106,128],"higher":[72,87,129],"primary":[74],"GC":[75,91,135],"tissues":[76,79],"than":[77,92,137],"normal":[78],"(P":[80,95,123,141,168],"=":[81,169],"0.0215).":[82],"Plasma":[83],"with":[90,165],"controls":[94,140],"<":[96,124,142],"0.0001).":[97,125,143],"(2)":[98],"In":[99],"test":[100],"larger":[102],"cohort,":[103],"there":[104],"decreasing":[107],"tendency":[108],"from":[112],"before,":[114],"14":[115],"days":[116],"1":[118],"month":[119],"after":[120],"surgical":[121],"resection":[122],"There":[126],"80":[134],"70":[139],"Receiver":[144],"operating":[145],"characteristics":[146],"(ROC)":[147],"curves":[148],"yielded":[149],"area":[150],"under":[151],"curve":[153],"(AUC)":[154],"value":[155],"0.845.":[157],"Moreover,":[158],"high":[159],"had":[162],"significant":[163],"correlation":[164],"distant":[166],"metastasis":[167],"0.038).":[170],"Thus,":[171],"our":[172],"data":[173],"suggest":[174],"that":[175],"hemolysis-free":[180],"markers":[181]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}