{"id":"https://openalex.org/W2417876707","doi":null,"title":"Drug therapy options for patients with irritable bowel syndrome.","display_name":"Drug therapy options for patients with irritable bowel syndrome.","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W2417876707","mag":"2417876707","pmid":"https://pubmed.ncbi.nlm.nih.gov/11474911"},"language":"en","primary_location":{"id":"pmid:11474911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11474911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of managed care","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111516278","display_name":"NJ Talley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"N J Talley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111516278"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.029,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.86447508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"7","issue":"8 Suppl","first_page":"S261","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13289","display_name":"Infant Health and Development","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":1.0},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/serotonin-receptors","display_name":"serotonin receptors","score":0.7179999947547913},{"id":"https://openalex.org/keywords/5-ht4-receptor-agonist","display_name":"5-HT4 receptor agonist","score":0.8859999775886536},{"id":"https://openalex.org/keywords/5-ht3-receptor-antagonists","display_name":"5-HT3 receptor antagonists","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tegaserod","display_name":"tegaserod","score":1.0},{"id":"https://openalex.org/keywords/alosetron","display_name":"alosetron","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prucalopride","display_name":"prucalopride","score":1.0},{"id":"https://openalex.org/keywords/abdominal-pain","display_name":"abdominal pain","score":0.800000011920929},{"id":"https://openalex.org/keywords/bloating","display_name":"bloating","score":0.8669999837875366},{"id":"https://openalex.org/keywords/constipation","display_name":"constipation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.7919999957084656},{"id":"https://openalex.org/keywords/colonic-transit","display_name":"colonic transit","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mebeverine","display_name":"mebeverine","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C2781419993","wikidata":"https://www.wikidata.org/wiki/Q44944","display_name":"Tegaserod","level":3,"score":0.9904931783676147},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9597009420394897},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.8408709168434143},{"id":"https://openalex.org/C2776956441","wikidata":"https://www.wikidata.org/wiki/Q4927059","display_name":"Bloating","level":3,"score":0.7086290121078491},{"id":"https://openalex.org/C2781112942","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Constipation","level":2,"score":0.6789683103561401},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6304103136062622},{"id":"https://openalex.org/C2780955771","wikidata":"https://www.wikidata.org/wiki/Q183425","display_name":"Abdominal pain","level":2,"score":0.5886367559432983},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.580973207950592},{"id":"https://openalex.org/C2777247143","wikidata":"https://www.wikidata.org/wiki/Q1429522","display_name":"Prokinetic agent","level":2,"score":0.5295085906982422},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4783596396446228},{"id":"https://openalex.org/C108797546","wikidata":"https://www.wikidata.org/wiki/Q204015","display_name":"Defecation","level":2,"score":0.4472702741622925},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4336015284061432},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.43029487133026123},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10032990574836731},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003109","descriptor_name":"Colonic Diseases, Functional","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003109","descriptor_name":"Colonic Diseases, Functional","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003248","descriptor_name":"Constipation","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005769","descriptor_name":"Gastrointestinal Motility","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015746","descriptor_name":"Abdominal Pain","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11474911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11474911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of managed care","raw_type":"Journal Article"},{"id":"mag:2417876707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11474911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W94291018","https://openalex.org/W1971724445","https://openalex.org/W1975882710","https://openalex.org/W1982769235","https://openalex.org/W1998457950","https://openalex.org/W2020410820","https://openalex.org/W2024341371","https://openalex.org/W2031664149","https://openalex.org/W2075334766","https://openalex.org/W2095055104","https://openalex.org/W2118329435","https://openalex.org/W2118366970","https://openalex.org/W2127837438"],"related_works":["https://openalex.org/W1968211000","https://openalex.org/W1717626108","https://openalex.org/W1988680300","https://openalex.org/W7061977582","https://openalex.org/W2155743510","https://openalex.org/W2138579314","https://openalex.org/W2401263083","https://openalex.org/W1897273837","https://openalex.org/W2060809912","https://openalex.org/W1975600390"],"abstract_inverted_index":{"Existing":[0],"pharmacotherapeutic":[1],"options":[2],"for":[3,60,187],"the":[4,17,22,29],"treatment":[5,89,169],"of":[6,31,139,148,176,202],"patients":[7,94,161,206],"with":[8,21,91,95,118,154,162,207],"irritable":[9],"bowel":[10,115,122],"syndrome":[11],"(IBS)":[12],"are":[13],"limited":[14],"in":[15,28,47,109,121,158,204],"treating":[16],"multiple":[18],"symptoms":[19],"associated":[20],"disorder.":[23],"There":[24],"is":[25,75,184],"much":[26],"interest":[27],"use":[30],"serotonin":[32,44,55],"agents":[33,56],"as":[34],"new":[35],"therapeutics.":[36],"Acting":[37],"primarily":[38],"through":[39],"5-HT3":[40,71],"and":[41,50,68,98,101,114,125,129,151,168,193],"5-HT4":[42,64,179],"receptors,":[43],"elicits":[45],"changes":[46],"motor":[48],"function":[49],"possibly":[51],"visceral":[52],"sensation.":[53],"Two":[54],"were":[57],"developed":[58,186],"specifically":[59],"IBS:":[61],"tegaserod,":[62,92],"a":[63,70,87,174],"receptor":[65,72,180],"partial":[66],"agonist,":[67,181],"alosetron,":[69],"antagonist":[73],"(which":[74],"no":[76],"longer":[77],"available).":[78],"Phase":[79],"III":[80],"clinical":[81],"trial":[82],"data":[83],"show":[84],"that":[85],"during":[86],"12-week":[88],"period":[90],"IBS":[93,160,205],"abdominal":[96,112,149],"pain":[97,130,150],"discomfort,":[99],"bloating,":[100],"constipation":[102],"experienced":[103],"significant":[104,146],"global":[105],"relief":[106,147],"(i.e.,":[107],"improvement":[108],"overall":[110],"well-being,":[111],"pain,":[113],"habit)":[116],"compared":[117,153],"placebo.":[119],"Improvement":[120],"movement":[123],"frequency":[124],"consistency":[126],"was":[127,131,142,171],"achieved":[128],"relieved":[132],"by":[133],"1":[134],"week.":[135],"During":[136],"12":[137],"weeks":[138],"treatment,":[140],"alosetron":[141],"shown":[143],"to":[144],"elicit":[145],"discomfort":[152],"placebo":[155],"or":[156],"mebeverine":[157],"female":[159],"diarrhea.":[163],"Alosetron":[164],"slowed":[165],"colonic":[166,191],"transit":[167,192],"efficacy":[170],"apparent":[172],"after":[173],"week":[175],"treatment.":[177],"Another":[178],"prucalopride,":[182],"which":[183],"being":[185],"chronic":[188],"constipation,":[189],"accelerates":[190],"increases":[194],"stool":[195],"frequency.":[196],"Therefore,":[197],"this":[198],"agent":[199],"may":[200],"be":[201],"benefit":[203],"constipation.":[208]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}