{"id":"https://openalex.org/W2417847656","doi":null,"title":"Inhibition of chemokine-induced chemotaxis of monkey leukocytes by mu-opioid receptor agonists.","display_name":"Inhibition of chemokine-induced chemotaxis of monkey leukocytes by mu-opioid receptor agonists.","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W2417847656","mag":"2417847656","pmid":"https://pubmed.ncbi.nlm.nih.gov/10654191"},"language":"en","primary_location":{"id":"pmid:10654191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10654191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108537371","display_name":"Yeon Ho Choi","orcid":"https://orcid.org/0009-0007-4296-6451","observed_orcids":["https://orcid.org/0009-0007-4296-6451"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Choi","raw_affiliation_strings":["Department of Medical Pharmacology & Toxicology, University of California, Davis 752-7710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Pharmacology & Toxicology, University of California, Davis 752-7710, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108583654","display_name":"L.F. Chuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L F Chuang","raw_affiliation_strings":["University Of California at Davis#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Of California at Davis#TAB#","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113558517","display_name":"Kenneth Ming-chih Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K M Lam","raw_affiliation_strings":["University Of California at Davis#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Of California at Davis#TAB#","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109103854","display_name":"Hsiang Fu Kung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H F Kung","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103178695","display_name":"Ji Ming Wang","orcid":"https://orcid.org/0000-0002-7381-5695","observed_orcids":["https://orcid.org/0000-0002-7381-5695"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J M Wang","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038996158","display_name":"Bennie Irve Osburn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B I Osburn","raw_affiliation_strings":["UC Davis School of Medicine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UC Davis School of Medicine;","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111381988","display_name":"Ronald Y. Chuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Y Chuang","raw_affiliation_strings":["University Of California at Davis#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Of California at Davis#TAB#","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8435,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.68802333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"5","first_page":"389","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.15760000050067902,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mu-opioid-receptor-agonists","display_name":"mu-opioid receptor agonists","score":0.9639999866485596},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mip-1beta","display_name":"MIP-1\u03b2","score":0.9409999847412109},{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":1.0},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.9710000157356262},{"id":"https://openalex.org/keywords/damgo","display_name":"DAMGO","score":0.9810000061988831},{"id":"https://openalex.org/keywords/methadone","display_name":"methadone","score":0.996999979019165},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.8804447054862976},{"id":"https://openalex.org/C2776401185","wikidata":"https://www.wikidata.org/wiki/Q5204254","display_name":"DAMGO","level":5,"score":0.8024344444274902},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.633556604385376},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.6167611479759216},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5894472599029541},{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.5210063457489014},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5163211226463318},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4501299262046814},{"id":"https://openalex.org/C2777019824","wikidata":"https://www.wikidata.org/wiki/Q417915","display_name":"Sufentanil","level":2,"score":0.43584173917770386},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4244411289691925},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3695434629917145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3151441216468811},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0692102313041687}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002464","descriptor_name":"Cell Migration Inhibition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019402","descriptor_name":"Macrophage Inflammatory Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019402","descriptor_name":"Macrophage Inflammatory Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054407","descriptor_name":"Chemokine CCL4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10654191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10654191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Journal Article"},{"id":"mag:2417847656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10654191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1959430850","display_name":"OPIOID DEPENDENCY AND AIDS","funder_award_id":"5r01da005901-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G289498232","display_name":"OPIOID RECEPTORS ON LYMPHOCYTES","funder_award_id":"5r01da010433-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2020620814","https://openalex.org/W2020309038","https://openalex.org/W2035646853","https://openalex.org/W7097788964","https://openalex.org/W2184743641","https://openalex.org/W1971491668","https://openalex.org/W2011242484","https://openalex.org/W2016442644","https://openalex.org/W2098919455","https://openalex.org/W2201960130"],"abstract_inverted_index":{"It":[0,77],"is":[1],"recognized":[2],"that":[3,80,142],"chemotaxis":[4,40,74,97],"and":[5,17,28,53,58,68,90],"phagocytosis":[6],"constitute":[7],"the":[8,14,31,56,59,71,93,104,126,129],"first":[9],"line":[10],"of":[11,35,41,61,73,98,106,128],"defense":[12],"in":[13,103,136],"immune":[15,149],"system,":[16,95],"chemokines":[18,48,82],"function":[19],"mainly":[20],"as":[21,55,85,138,140,145],"chemoattractants":[22,86],"for":[23,87,132],"phagocytic":[24],"cells,":[25],"recruiting":[26],"monocytes":[27],"neutrophils":[29],"from":[30],"blood":[32],"to":[33,92],"sites":[34],"infection.":[36],"In":[37],"this":[38],"study,":[39],"monkey":[42,88,99,130],"leukocytes":[43,100],"was":[44,78,101],"evaluated":[45],"using":[46],"human":[47,81,94],"IL-8":[49],"(interleukin-8),":[50],"MIP-1":[51],"beta":[52],"RANTES":[54],"chemoattractants,":[57],"effects":[60],"micro-opioid":[62,107,119,152],"receptor":[63,108,120],"agonists,":[64],"morphine,":[65],"DAMGO,":[66],"methadone":[67],"endomorphine,":[69],"on":[70,154],"efficiency":[72],"were":[75],"examined.":[76],"found":[79],"served":[83],"well":[84,139],"leukocytes,":[89],"similar":[91],"chemokine-induced":[96],"inhibited":[102],"presence":[105],"agonists.":[109],"The":[110],"inhibition":[111],"could":[112],"be":[113],"reversed":[114],"by":[115],"naloxone,":[116],"a":[117],"specific":[118],"antagonist.":[121],"These":[122],"studies":[123,135],"further":[124],"support":[125],"value":[127],"model":[131],"drug":[133],"abuse":[134],"humans,":[137],"suggest":[141],"opioids":[143],"such":[144],"morphine":[146],"may":[147],"alter":[148],"functions":[150],"through":[151],"receptors":[153],"leukocytes.":[155]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
