{"id":"https://openalex.org/W2417638979","doi":"https://doi.org/10.1007/bf01856036","title":"Metabolische Wirkungen von Phenylaethylbiguanid (Phenformin) auf die h\u00e4moglobinfrei perfundierte Rattenleber","display_name":"Metabolische Wirkungen von Phenylaethylbiguanid (Phenformin) auf die h\u00e4moglobinfrei perfundierte Rattenleber","publication_year":1972,"publication_date":"1972-06-01","ids":{"openalex":"https://openalex.org/W2417638979","doi":"https://doi.org/10.1007/bf01856036","mag":"2417638979","pmid":"https://pubmed.ncbi.nlm.nih.gov/4647908"},"language":"de","primary_location":{"id":"doi:10.1007/bf01856036","doi":"https://doi.org/10.1007/bf01856036","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01856036","pdf_url":null,"source":{"id":"https://openalex.org/S86772520","display_name":"Research in Experimental Medicine","issn_l":"0300-9130","issn":["0300-9130","1433-8580"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043135537","display_name":"Joachim Grunst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Grunst","raw_affiliation_strings":["I. Medizinische Klinik der Universit\u00e4t, Ziemssenstra\u00dfe 1a, D-8000, M\u00fcnchen 15, Bundesrepublik Deutschland","I. Medizinische Klinik der Universit\u00e4t, M\u00fcnchen 15, Bundesrepublik Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I. Medizinische Klinik der Universit\u00e4t, Ziemssenstra\u00dfe 1a, D-8000, M\u00fcnchen 15, Bundesrepublik Deutschland","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"I. Medizinische Klinik der Universit\u00e4t, M\u00fcnchen 15, Bundesrepublik Deutschland","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015997126","display_name":"M Teilken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Teilken","raw_affiliation_strings":["I. Medizinische Klinik der Universit\u00e4t, Ziemssenstra\u00dfe 1a, D-8000, M\u00fcnchen 15, Bundesrepublik Deutschland","I. Medizinische Klinik der Universit\u00e4t, M\u00fcnchen 15, Bundesrepublik Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I. Medizinische Klinik der Universit\u00e4t, Ziemssenstra\u00dfe 1a, D-8000, M\u00fcnchen 15, Bundesrepublik Deutschland","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"I. Medizinische Klinik der Universit\u00e4t, M\u00fcnchen 15, Bundesrepublik Deutschland","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055093338","display_name":"Hendrik Dobbelstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. Dobbelstein","raw_affiliation_strings":["I. Medizinische Klinik der Universit\u00e4t, Ziemssenstra\u00dfe 1a, D-8000, M\u00fcnchen 15, Bundesrepublik Deutschland","I. Medizinische Klinik der Universit\u00e4t, M\u00fcnchen 15, Bundesrepublik Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I. Medizinische Klinik der Universit\u00e4t, Ziemssenstra\u00dfe 1a, D-8000, M\u00fcnchen 15, Bundesrepublik Deutschland","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"I. Medizinische Klinik der Universit\u00e4t, M\u00fcnchen 15, Bundesrepublik Deutschland","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045008840","display_name":"Josef Eisenburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Eisenburg","raw_affiliation_strings":["I. Medizinische Klinik der Universit\u00e4t, Ziemssenstra\u00dfe 1a, D-8000, M\u00fcnchen 15, Bundesrepublik Deutschland","I. Medizinische Klinik der Universit\u00e4t, M\u00fcnchen 15, Bundesrepublik Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I. Medizinische Klinik der Universit\u00e4t, Ziemssenstra\u00dfe 1a, D-8000, M\u00fcnchen 15, Bundesrepublik Deutschland","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"I. Medizinische Klinik der Universit\u00e4t, M\u00fcnchen 15, Bundesrepublik Deutschland","institution_ids":["https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I8204097"],"apc_list":null,"apc_paid":null,"fwci":0.1598,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.42949355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"159","issue":"2","first_page":"99","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.12160000205039978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.03799999877810478,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenformin","display_name":"phenformin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/biguanides","display_name":"biguanides","score":0.6449999809265137},{"id":"https://openalex.org/keywords/liver-metabolism","display_name":"hepatic metabolism","score":0.5720000267028809},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.734000027179718},{"id":"https://openalex.org/keywords/electron-transport-inhibition","display_name":"electron transport inhibition","score":0.7279999852180481},{"id":"https://openalex.org/keywords/atp-adp-ratio","display_name":"ATP/ADP ratio","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lactic-acid-production","display_name":"lactic acid production","score":0.5019999742507935},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/beta-hydroxybutyrate","display_name":"beta-hydroxybutyrate","score":0.8370000123977661},{"id":"https://openalex.org/keywords/acetoacetate","display_name":"acetoacetate","score":0.824999988079071},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":0.7540000081062317},{"id":"https://openalex.org/keywords/anoxia","display_name":"anoxia","score":0.6340000033378601},{"id":"https://openalex.org/keywords/isolated-perfused-liver","display_name":"isolated perfused liver","score":0.5569999814033508},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.870570182800293},{"id":"https://openalex.org/C2778877718","wikidata":"https://www.wikidata.org/wiki/Q753100","display_name":"Phenformin","level":4,"score":0.5407876968383789},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3389165699481964},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33023154735565186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07651057839393616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07624953985214233},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.061252713203430176},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.032054245471954346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000090","descriptor_name":"Acetoacetates","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006885","descriptor_name":"Hydroxybutyrates","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010629","descriptor_name":"Phenformin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf01856036","doi":"https://doi.org/10.1007/bf01856036","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01856036","pdf_url":null,"source":{"id":"https://openalex.org/S86772520","display_name":"Research in Experimental Medicine","issn_l":"0300-9130","issn":["0300-9130","1433-8580"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in Experimental Medicine","raw_type":"journal-article"},{"id":"pmid:4647908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4647908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W10006180","https://openalex.org/W37483700","https://openalex.org/W52539439","https://openalex.org/W162787695","https://openalex.org/W1524861164","https://openalex.org/W1595878159","https://openalex.org/W1972304414","https://openalex.org/W1996225323","https://openalex.org/W1998840978","https://openalex.org/W2004268886","https://openalex.org/W2010120306","https://openalex.org/W2015335226","https://openalex.org/W2016744967","https://openalex.org/W2037117734","https://openalex.org/W2043463709","https://openalex.org/W2049153018","https://openalex.org/W2119931739","https://openalex.org/W2142802046","https://openalex.org/W2312241647","https://openalex.org/W2313627757","https://openalex.org/W2410838241","https://openalex.org/W2412351627","https://openalex.org/W2414054383","https://openalex.org/W2437555566","https://openalex.org/W2476498331","https://openalex.org/W2604432462","https://openalex.org/W2942507508"],"related_works":["https://openalex.org/W1981373293","https://openalex.org/W67955268","https://openalex.org/W2410165003","https://openalex.org/W2261781579","https://openalex.org/W2050210020","https://openalex.org/W2395690752","https://openalex.org/W1968083897","https://openalex.org/W74326227","https://openalex.org/W7096055210","https://openalex.org/W2400221245"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
