{"id":"https://openalex.org/W2417635199","doi":"https://doi.org/10.7727/wimj.2014.022","title":"Performance Assessment of The Polymerase Chain Reaction-restriction Fragment Length Polymorphism Method for Rapid Detection of Susceptibility to Ethambutol and Molecular Prediction of XDR Tuberculosis in Clinical Isolates of Mycobacterium Tuberculosis","display_name":"Performance Assessment of The Polymerase Chain Reaction-restriction Fragment Length Polymorphism Method for Rapid Detection of Susceptibility to Ethambutol and Molecular Prediction of XDR Tuberculosis in Clinical Isolates of Mycobacterium Tuberculosis","publication_year":2015,"publication_date":"2015-07-07","ids":{"openalex":"https://openalex.org/W2417635199","doi":"https://doi.org/10.7727/wimj.2014.022","mag":"2417635199","pmid":"https://pubmed.ncbi.nlm.nih.gov/26624582","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4909062"},"language":"en","primary_location":{"id":"doi:10.7727/wimj.2014.022","doi":"https://doi.org/10.7727/wimj.2014.022","is_oa":true,"landing_page_url":"https://doi.org/10.7727/wimj.2014.022","pdf_url":"https://www.mona.uwi.edu/fms/wimj/system/files/article_pdfs/wimjsep2015_325_332_0.pdf","source":{"id":"https://openalex.org/S91061106","display_name":"West Indian Medical Journal","issn_l":"0043-3144","issn":["0043-3144","2309-5830"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321386","host_organization_name":"University of the West Indies Press","host_organization_lineage":["https://openalex.org/P4310321386"],"host_organization_lineage_names":["University of the West Indies Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West Indian Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.mona.uwi.edu/fms/wimj/system/files/article_pdfs/wimjsep2015_325_332_0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024240363","display_name":"Mohammad Arjomandzadegan","orcid":"https://orcid.org/0000-0002-2724-3534","observed_orcids":["https://orcid.org/0000-0002-2724-3534"]},"institutions":[{"id":"https://openalex.org/I133903919","display_name":"Arak University of Medical Sciences","ror":"https://ror.org/056mgfb42","country_code":"IR","type":"education","lineage":["https://openalex.org/I133903919"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"M Arjomandzadegan","raw_affiliation_strings":["Infectious Diseases Research Center and Department of Microbiology, Arak University of Medical Sciences, Arak, Iran. mmatinam81@yahoo.com; arjomandzadegan@arakmu.ac.irn","Infectious Diseases Research C enter (IDRC), Arak University of Medical Sciences, Arak, Iran,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Center and Department of Microbiology, Arak University of Medical Sciences, Arak, Iran. mmatinam81@yahoo.com; arjomandzadegan@arakmu.ac.irn","institution_ids":["https://openalex.org/I133903919"]},{"raw_affiliation_string":"Infectious Diseases Research C enter (IDRC), Arak University of Medical Sciences, Arak, Iran,","institution_ids":["https://openalex.org/I133903919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006887477","display_name":"Razieh Nazari","orcid":"https://orcid.org/0000-0002-3487-1416","observed_orcids":["https://orcid.org/0000-0002-3487-1416","https://orcid.org/0000-0003-4819-5735"]},"institutions":[{"id":"https://openalex.org/I4210113955","display_name":"Qom Islamic Azad University","ror":"https://ror.org/0283g3v77","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I4210113955"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"R Nazari","raw_affiliation_strings":["Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran","institution_ids":["https://openalex.org/I4210113955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066272469","display_name":"Mohammad Reza Zolfaghari","orcid":"https://orcid.org/0000-0003-1377-1990","observed_orcids":["https://orcid.org/0000-0003-1377-1990","https://orcid.org/0000-0002-9004-1687"]},"institutions":[{"id":"https://openalex.org/I4210113955","display_name":"Qom Islamic Azad University","ror":"https://ror.org/0283g3v77","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I4210113955"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"MR Zolfaghari","raw_affiliation_strings":["Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran,","institution_ids":["https://openalex.org/I4210113955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078721349","display_name":"Masumeh Taherahmadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113955","display_name":"Qom Islamic Azad University","ror":"https://ror.org/0283g3v77","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I4210113955"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"M Taherahmadi","raw_affiliation_strings":["Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran","institution_ids":["https://openalex.org/I4210113955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004593600","display_name":"Maryam Sadrnia","orcid":"https://orcid.org/0000-0003-2030-3343","observed_orcids":["https://orcid.org/0000-0003-2030-3343"]},"institutions":[{"id":"https://openalex.org/I55547365","display_name":"Payame Noor University","ror":"https://ror.org/031699d98","country_code":"IR","type":"education","lineage":["https://openalex.org/I55547365"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"M Sadrnia","raw_affiliation_strings":["Department of Biology, Payame Noor University, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Payame Noor University, Tehran, Iran","institution_ids":["https://openalex.org/I55547365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112296616","display_name":"L.P. Titov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158895","display_name":"Republican Research and Practical Center for Epidemiology and Microbiology","ror":"https://ror.org/05hpjvd22","country_code":"BY","type":"facility","lineage":["https://openalex.org/I1318325419","https://openalex.org/I4210158895"]}],"countries":["BY"],"is_corresponding":false,"raw_author_name":"LP Titov","raw_affiliation_strings":["Research Institute for Epidemiology and Microbiology, Minsk, Belarus","Research Institute for Epidemiology and Mi-crobiology, Minsk, Belarus and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Epidemiology and Microbiology, Minsk, Belarus","institution_ids":["https://openalex.org/I4210158895"]},{"raw_affiliation_string":"Research Institute for Epidemiology and Mi-crobiology, Minsk, Belarus and","institution_ids":["https://openalex.org/I4210158895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085407235","display_name":"Azam Ahmadi","orcid":"https://orcid.org/0000-0003-3026-0471","observed_orcids":["https://orcid.org/0000-0003-3026-0471"]},"institutions":[{"id":"https://openalex.org/I133903919","display_name":"Arak University of Medical Sciences","ror":"https://ror.org/056mgfb42","country_code":"IR","type":"education","lineage":["https://openalex.org/I133903919"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"A Ahmadi","raw_affiliation_strings":["Infectious Diseases Research Center (IDRC), Arak University of Medical Sciences, Arak, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Center (IDRC), Arak University of Medical Sciences, Arak, Iran","institution_ids":["https://openalex.org/I133903919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018962967","display_name":"Mana Shojapoor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133903919","display_name":"Arak University of Medical Sciences","ror":"https://ror.org/056mgfb42","country_code":"IR","type":"education","lineage":["https://openalex.org/I133903919"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"M Shojapoor","raw_affiliation_strings":["Research Center of Molecular Medicine, Arak University of Medical Sciences, Arak, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center of Molecular Medicine, Arak University of Medical Sciences, Arak, Iran","institution_ids":["https://openalex.org/I133903919"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5024240363"],"corresponding_institution_ids":["https://openalex.org/I133903919"],"apc_list":null,"apc_paid":null,"fwci":0.2307,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5367414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"64","issue":"4","first_page":"325","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethambutol-resistance","display_name":"ethambutol resistance","score":0.9359999895095825},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/extensively-drug-resistant-tuberculosis","display_name":"extensively drug-resistant tuberculosis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/pre-xdr-tuberculosis","display_name":"pre-XDR tuberculosis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/pcr-rflp","display_name":"PCR-RFLP","score":0.8149999976158142},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.7020000219345093},{"id":"https://openalex.org/keywords/secondary-tuberculosis","display_name":"secondary tuberculosis","score":0.6340000033378601},{"id":"https://openalex.org/keywords/primary-tuberculosis","display_name":"primary tuberculosis","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C168007829","wikidata":"https://www.wikidata.org/wiki/Q857299","display_name":"Restriction fragment length polymorphism","level":4,"score":0.7790289521217346},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.7734323740005493},{"id":"https://openalex.org/C2776228421","wikidata":"https://www.wikidata.org/wiki/Q412318","display_name":"Ethambutol","level":4,"score":0.7430195808410645},{"id":"https://openalex.org/C2776906770","wikidata":"https://www.wikidata.org/wiki/Q936454","display_name":"HaeIII","level":5,"score":0.7024271488189697},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6415190696716309},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5798375010490417},{"id":"https://openalex.org/C128319531","wikidata":"https://www.wikidata.org/wiki/Q219715","display_name":"Restriction enzyme","level":3,"score":0.5379430055618286},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4531860053539276},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.43579739332199097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43530669808387756},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3944768011569977},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32461249828338623},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.22358110547065735},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20574921369552612},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20250234007835388},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.047537922859191895}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7727/wimj.2014.022","doi":"https://doi.org/10.7727/wimj.2014.022","is_oa":true,"landing_page_url":"https://doi.org/10.7727/wimj.2014.022","pdf_url":"https://www.mona.uwi.edu/fms/wimj/system/files/article_pdfs/wimjsep2015_325_332_0.pdf","source":{"id":"https://openalex.org/S91061106","display_name":"West Indian Medical Journal","issn_l":"0043-3144","issn":["0043-3144","2309-5830"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321386","host_organization_name":"University of the West Indies Press","host_organization_lineage":["https://openalex.org/P4310321386"],"host_organization_lineage_names":["University of the West Indies Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West Indian Medical Journal","raw_type":"journal-article"},{"id":"pmid:26624582","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26624582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The West Indian medical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4909062","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4909062/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West Indian Med J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7727/wimj.2014.022","doi":"https://doi.org/10.7727/wimj.2014.022","is_oa":true,"landing_page_url":"https://doi.org/10.7727/wimj.2014.022","pdf_url":"https://www.mona.uwi.edu/fms/wimj/system/files/article_pdfs/wimjsep2015_325_332_0.pdf","source":{"id":"https://openalex.org/S91061106","display_name":"West Indian Medical Journal","issn_l":"0043-3144","issn":["0043-3144","2309-5830"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321386","host_organization_name":"University of the West Indies Press","host_organization_lineage":["https://openalex.org/P4310321386"],"host_organization_lineage_names":["University of the West Indies Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West Indian Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2417635199.pdf","grobid_xml":"https://content.openalex.org/works/W2417635199.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W338427105","https://openalex.org/W1657320981","https://openalex.org/W1965060228","https://openalex.org/W1973039152","https://openalex.org/W1991252320","https://openalex.org/W2000552229","https://openalex.org/W2020661238","https://openalex.org/W2030144417","https://openalex.org/W2036980040","https://openalex.org/W2046417607","https://openalex.org/W2083786241","https://openalex.org/W2113220407","https://openalex.org/W2118374299","https://openalex.org/W2119142977","https://openalex.org/W2124628939","https://openalex.org/W2139924463","https://openalex.org/W2152075272","https://openalex.org/W2157737997","https://openalex.org/W2158912328","https://openalex.org/W2166635511","https://openalex.org/W2739014007","https://openalex.org/W7073736478"],"related_works":["https://openalex.org/W2000552229","https://openalex.org/W2239983914","https://openalex.org/W2766558909","https://openalex.org/W1984119234","https://openalex.org/W2334809994","https://openalex.org/W2362168206","https://openalex.org/W2887258176","https://openalex.org/W1485358768","https://openalex.org/W2394151776","https://openalex.org/W2300518434"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1,99,264],"polymerase":[2],"chain":[3,63],"reaction-restriction":[4],"fragment":[5],"length":[6],"polymorphism":[7],"(PCR-RFLP)":[8],"method":[9,51,145,212],"was":[10,46,54,213,227],"employed":[11],"for":[12,59,271],"rapid":[13,272],"detection":[14,254],"of":[15,21,31,77,90,101,143,179,200,209,222,237,255,274,278],"ethambutol":[16],"(EMB)":[17],"resistant":[18,96,138],"clinical":[19,29],"isolates":[20,30,245],"Mycobacterium":[22],"tuberculosis.":[23],"MATERIALS":[24],"AND":[25],"METHODS:":[26],"From":[27,119],"182":[28],"M":[32],"tuberculosis":[33,103],"collected":[34],"from":[35,148,163],"different":[36],"regions,":[37],"103":[38,91],"strains":[39,136,226,232],"were":[40,66,80,86,95,104,137,202],"entered":[41],"in":[42,195],"the":[43,75,210,223],"investigation.":[44],"DNA":[45],"extracted":[47],"by":[48,262],"Chelex":[49],"100":[50],"and":[52,70,74,109,125,133,160,175,178,190,218,243,280],"PCR":[53],"performed":[55],"using":[56,286],"specific":[57],"primers":[58],"embB":[60],"gene.":[61],"Polymerase":[62],"reaction":[64],"products":[65],"digested":[67],"with":[68,156,171,186,204],"HaeIII":[69],"NlaII":[71],"restriction":[72,78],"endonucleases":[73],"patterns":[76],"fragments":[79],"analysed.":[81],"Some":[82],"randomly":[83],"selected":[84],"samples":[85],"sequenced.":[87],"RESULTS:":[88],"Out":[89],"studied":[92],"strains,":[93,167],"52":[94],"to":[97,139,257,283],"EMB.":[98],"cases":[100,111],"secondary":[102],"53":[105],"(51.50":[106],"\u00b1":[107,114],"1.77%),":[108],"primary":[110],"50":[112],"(48.50":[113],"1.77%;":[115],"p":[116,249],">":[117],"0.05).":[118],"63":[120],"extensively":[121],"drug-resistant":[122,231],"(XDR),":[123],"pre-XDR":[124,166,242],"multidrug-resistant":[126],"(MDR)":[127],"isolates,":[128,152],"27":[129],"(87%),":[130],"18":[131],"(81.8%)":[132],"7":[134],"(70%)":[135],"EMB,":[140],"respectively.":[141],"Results":[142,199],"PCR-RFLP":[144],"showed":[146],"that":[147],"27R":[149],"EMB":[150,165,181,258],"XDR":[151,281],"13":[153],"(sensitivity":[154,169,184],"48%":[155],"CI:":[157,172,187],"0.307,":[158],"0.66":[159],"specificity":[161,176,191,219],"100%),":[162],"18R":[164],"4":[168],"22%":[170],"0.09,":[173,216],"0.45":[174],"100%)":[177,192],"7R":[180],"MDR,":[182],"2":[183],"28%":[185],"0.082,":[188],"0.64":[189],"had":[193,233],"mutation":[194],"ATG-Met":[196],"codon":[197],"306.":[198],"sequencing":[201],"concordant":[203],"RFLP":[205],"method.":[206,288],"Overall,":[207],"sensitivity":[208],"molecular":[211],"36.5%":[214],"(CI:":[215],"0.45)":[217],"100%.":[220],"None":[221],"40":[224],"pansusceptible":[225],"embB306":[228,238,265],"mutants.":[229],"Extensively":[230],"a":[234,268],"higher":[235],"proportion":[236],"mutants":[239],"(43%)":[240],"than":[241],"MDR":[244,279],"(odds":[246],"ratio":[247],"6.78;":[248],"<":[250],"0.001).":[251],"CONCLUSION:":[252],"Fast":[253],"susceptibility":[256],"drug":[259],"is":[260,267],"possible":[261],"PCR-RFLP.":[263],"locus":[266],"candidate":[269],"marker":[270],"prediction":[273],"high":[275],"resistance":[276],"consisting":[277],"forms":[282],"anti-tuberculosis":[284],"drugs":[285],"this":[287]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}