{"id":"https://openalex.org/W2417458047","doi":null,"title":"Open-label infliximab therapy in ulcerative colitis: a multicenter survey of results and predictors of response.","display_name":"Open-label infliximab therapy in ulcerative colitis: a multicenter survey of results and predictors of response.","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W2417458047","mag":"2417458047","pmid":"https://pubmed.ncbi.nlm.nih.gov/19102352"},"language":"en","primary_location":{"id":"pmid:19102352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19102352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027812355","display_name":"Yago Gonz\u00e1lez\u2010Lama","orcid":"https://orcid.org/0000-0003-3896-7914","observed_orcids":["https://orcid.org/0000-0003-3896-7914"]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Yago Gonzalez-Lama","raw_affiliation_strings":["Digestive Department of La Princesa Universitary Hospital, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digestive Department of La Princesa Universitary Hospital, Madrid, Spain","institution_ids":["https://openalex.org/I4210130498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050157714","display_name":"Ignacio Fern\u00e1ndez-Blanco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ignacio Fernandez-Blanco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028941216","display_name":"Antonio L\u00f3pez\u2013Sanrom\u00e1n","orcid":"https://orcid.org/0000-0003-0236-4118","observed_orcids":["https://orcid.org/0000-0003-0236-4118","https://orcid.org/0000-0002-9417-3484"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio Lopez-SanRoman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013238742","display_name":"Carlos Taxonera","orcid":"https://orcid.org/0000-0001-9166-7350","observed_orcids":["https://orcid.org/0000-0001-9166-7350"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Taxonera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035044865","display_name":"B Cas\u00eds","orcid":"https://orcid.org/0000-0002-1729-6472","observed_orcids":["https://orcid.org/0000-0002-1729-6472"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bego\u00f1a Casis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061830172","display_name":"Susana Tabernero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susana Tabernero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037356434","display_name":"Fernando Bermejo","orcid":"https://orcid.org/0000-0003-4610-0886","observed_orcids":["https://orcid.org/0000-0003-4610-0886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando Bermejo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062054161","display_name":"Francisca Mart\u00ednez-Silva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francisca Martinez-Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014029646","display_name":"Juan L. Mendoza","orcid":"https://orcid.org/0000-0001-6972-7476","observed_orcids":["https://orcid.org/0000-0001-6972-7476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Luis Mendoza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002854389","display_name":"Pilar Mart\u00ednez-Montiel","orcid":"https://orcid.org/0000-0002-8688-8244","observed_orcids":["https://orcid.org/0000-0002-8688-8244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pilar Martinez-Montiel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111652918","display_name":"Jos\u00e9 Antonio Carneros","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jose Antonio Carneros","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Fernando Sanchez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando Sanchez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113997606","display_name":"Jos\u00e9 Mat\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jose Mat\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014254734","display_name":"Javier P. Gisbert","orcid":"https://orcid.org/0000-0003-2090-3445","observed_orcids":["https://orcid.org/0000-0003-2090-3445","https://orcid.org/0000-0002-1703-670X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Javier P Gisbert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9975,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.93498101,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"55","issue":"86-87","first_page":"1609","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/predictors-of-treatment-response","display_name":"predictors of treatment response","score":0.6389999985694885},{"id":"https://openalex.org/keywords/clinical-response","display_name":"clinical response","score":0.6570000052452087},{"id":"https://openalex.org/keywords/steroid-free-remission","display_name":"steroid-free remission","score":0.9909999966621399},{"id":"https://openalex.org/keywords/disease-extent","display_name":"disease extent","score":0.7059999704360962},{"id":"https://openalex.org/keywords/thiopurine-therapy","display_name":"thiopurine therapy","score":0.8019999861717224},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.8199999928474426},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7699999809265137},{"id":"https://openalex.org/keywords/colectomy","display_name":"colectomy","score":0.8140000104904175},{"id":"https://openalex.org/keywords/real-world-efficacy","display_name":"real-world efficacy","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.9410372972488403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8935620784759521},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.8532774448394775},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6880882382392883},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5998876094818115},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.5962100028991699},{"id":"https://openalex.org/C2776667177","wikidata":"https://www.wikidata.org/wiki/Q1779148","display_name":"Colectomy","level":4,"score":0.5815114974975586},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5529725551605225},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4437800347805023},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4397696852684021},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41740483045578003},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35230904817581177},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3224305510520935}],"mesh":[{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19102352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19102352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},{"id":"mag:2417458047","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19102352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1530709545","https://openalex.org/W2978430891","https://openalex.org/W2921144821","https://openalex.org/W1972037257","https://openalex.org/W2312307058","https://openalex.org/W2079185331","https://openalex.org/W2212267171","https://openalex.org/W2406587738","https://openalex.org/W2975062969","https://openalex.org/W1971852927"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Results":[1],"of":[2,8,28,33,41,47,57,77,86,148,160,189],"randomized":[3,185],"controlled":[4,186],"trials":[5],"showing":[6],"efficacy":[7,25],"infliximab":[9,29,53,88],"in":[10,17,30,54,99,104,184,200],"ulcerative":[11],"colitis":[12],"(UC)":[13],"should":[14],"be":[15],"confirmed":[16],"clinical":[18,39,176,198],"practice.":[19],"We":[20],"aimed":[21],"to":[22],"evaluate":[23],"the":[24,34,55,100,105,111,149,152,190,193],"and":[26,82,92,108,170],"safety":[27],"UC":[31,49,62],"patients":[32,50,63],"Madrid":[35,58],"area,":[36],"looking":[37],"for":[38,172,197],"predictors":[40],"response.":[42],"METHODOLOGY:":[43],"Multicenter":[44],"retrospective":[45],"survey":[46],"all":[48],"treated":[51],"with":[52],"region":[56],"(Spain).":[59],"RESULTS:":[60],"47":[61],"were":[64,164],"included":[65],"(45%":[66],"males,":[67],"mean":[68,74],"age":[69],"44":[70],"+/-":[71],"15":[72],"yrs),":[73],"follow":[75,113],"up":[76,114],"4.7":[78],"months":[79],"(range":[80],"0.5-21),":[81],"a":[83],"total":[84],"number":[85],"211":[87],"infusions.":[89],"Clinical":[90],"response":[91,199],"steroid-free":[93],"remission":[94],"rates":[95],"were,":[96],"respectively,":[97],"97/42%":[98],"2nd":[101],"week,":[102,107],"93/69%":[103],"6th":[106],"80/65%":[109],"at":[110],"long-term":[112],"(mean":[115],"8.2":[116],"months,":[117],"range":[118],"3.5-21).":[119],"Colectomy":[120],"rate":[121],"was":[122,151,192],"10.6%":[123],"(five":[124],"patients).":[125],"Age,":[126],"gender,":[127],"disease":[128,132,150,191],"duration,":[129],"indication":[130],"(steroid-resistance/dependence),":[131],"severity,":[133],"C-reactive":[134],"protein,":[135],"concomitant":[136],"thiopurinic":[137],"therapy":[138],"or":[139],"smoking":[140],"habit":[141],"did":[142],"not":[143],"influence":[144],"on":[145],"efficacy.":[146],"Extent":[147,188],"only":[153,194],"predictive":[154,195],"factor":[155,196],"(p=0.02).":[156],"Only":[157],"4":[158],"cases":[159],"mild":[161],"adverse":[162],"events":[163],"reported.":[165],"CONCLUSIONS:":[166],"Infliximab":[167],"is":[168],"effective":[169],"safe":[171],"UC.":[173],"Real":[174],"life":[175],"practice":[177],"may":[178],"have":[179],"better":[180],"outcome":[181],"than":[182],"showed":[183],"trials.":[187],"our":[201],"experience.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}