{"id":"https://openalex.org/W241735225","doi":"https://doi.org/10.1182/blood.v94.11.3872","title":"Spontaneous Apoptosis in Lymphocytes From Patients With Wiskott-Aldrich Syndrome: Correlation of Accelerated Cell Death and Attenuated Bcl-2 Expression","display_name":"Spontaneous Apoptosis in Lymphocytes From Patients With Wiskott-Aldrich Syndrome: Correlation of Accelerated Cell Death and Attenuated Bcl-2 Expression","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W241735225","doi":"https://doi.org/10.1182/blood.v94.11.3872","mag":"241735225","pmid":"https://pubmed.ncbi.nlm.nih.gov/10572103"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v94.11.3872","doi":"https://doi.org/10.1182/blood.v94.11.3872","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v94.11.3872","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091084141","display_name":"Stephen L. Rawlings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen L. Rawlings","raw_affiliation_strings":["From the Division of Research Immunology and Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Research Immunology and Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085643102","display_name":"Gay M. Crooks","orcid":"https://orcid.org/0000-0002-2488-8468","observed_orcids":["https://orcid.org/0000-0002-2488-8468"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gay M. Crooks","raw_affiliation_strings":["From the Division of Research Immunology and Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Research Immunology and Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066467846","display_name":"David C. Bockstoce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Bockstoce","raw_affiliation_strings":["From the Division of Research Immunology and Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Research Immunology and Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108407434","display_name":"Lora W. Barsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lora W. Barsky","raw_affiliation_strings":["From the Division of Research Immunology and Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Research Immunology and Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045306382","display_name":"Robertson Parkman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robertson Parkman","raw_affiliation_strings":["From the Division of Research Immunology and Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Research Immunology and Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046180673","display_name":"Kenneth I. Weinberg","orcid":"https://orcid.org/0000-0003-1922-9131","observed_orcids":["https://orcid.org/0000-0003-1922-9131"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth I. Weinberg","raw_affiliation_strings":["From the Division of Research Immunology and Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Research Immunology and Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1336910626"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.4826,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.81031384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"94","issue":"11","first_page":"3872","last_page":"3882"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wiskott-aldrich-syndrome","display_name":"Wiskott-Aldrich syndrome","score":1.0},{"id":"https://openalex.org/keywords/spontaneous-apoptosis","display_name":"spontaneous apoptosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/bcl-2-expression","display_name":"Bcl-2 expression","score":0.9549999833106995},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.7839999794960022},{"id":"https://openalex.org/keywords/wasps","display_name":"wasps","score":0.8190000057220459},{"id":"https://openalex.org/keywords/x-linked-immunodeficiency","display_name":"X-linked immunodeficiency","score":0.7850000262260437},{"id":"https://openalex.org/keywords/primary-immunodeficiency","display_name":"primary immunodeficiency","score":0.734000027179718},{"id":"https://openalex.org/keywords/lymphocyte-destruction","display_name":"lymphocyte destruction","score":0.593999981880188},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7811436653137207},{"id":"https://openalex.org/C2780939953","wikidata":"https://www.wikidata.org/wiki/Q8027658","display_name":"Wiskott\u2013Aldrich syndrome protein","level":5,"score":0.6280189752578735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6250779032707214},{"id":"https://openalex.org/C2778153459","wikidata":"https://www.wikidata.org/wiki/Q953638","display_name":"Wiskott\u2013Aldrich syndrome","level":3,"score":0.6210541725158691},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5792198181152344},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5459727644920349},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5325262546539307},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5231667160987854},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4770438075065613},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4625403881072998},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4333764612674713},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.41245365142822266},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.4107581377029419},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.33798474073410034},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32817190885543823},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26147931814193726},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20870620012283325},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.156112402677536}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014923","descriptor_name":"Wiskott-Aldrich Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014923","descriptor_name":"Wiskott-Aldrich Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v94.11.3872","doi":"https://doi.org/10.1182/blood.v94.11.3872","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v94.11.3872","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v94.11.3872.423k37_3872_3882","doi":"https://doi.org/10.1182/blood.v94.11.3872.423k37_3872_3882","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v94.11.3872.423k37_3872_3882","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:10572103","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10572103","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1189208975","display_name":null,"funder_award_id":"HL 54729","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1692041321","display_name":null,"funder_award_id":"HL54850","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4368159446","display_name":null,"funder_award_id":"AI-40581","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5251259329","display_name":"HSC DIFFERENTIATION","funder_award_id":"P50HL054850","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G785535762","display_name":"GENE THERAPY FOR SEVERE COMBINED IMMUNE DEFICIENCIES","funder_award_id":"5r01ai040581-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8160572707","display_name":"Enhancement of Post-BMT Immune Reconstitution by IL-7","funder_award_id":"R01HL054729","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W77948366","https://openalex.org/W125106425","https://openalex.org/W136220105","https://openalex.org/W197495146","https://openalex.org/W1481442945","https://openalex.org/W1481927174","https://openalex.org/W1492937665","https://openalex.org/W1517639955","https://openalex.org/W1524475817","https://openalex.org/W1529773650","https://openalex.org/W1530654031","https://openalex.org/W1532545761","https://openalex.org/W1599108866","https://openalex.org/W1601873036","https://openalex.org/W1618426198","https://openalex.org/W1801421732","https://openalex.org/W1821624036","https://openalex.org/W1865638202","https://openalex.org/W1874141802","https://openalex.org/W1940692702","https://openalex.org/W1964617786","https://openalex.org/W1972172786","https://openalex.org/W1975618936","https://openalex.org/W1979299838","https://openalex.org/W1980952363","https://openalex.org/W1986126368","https://openalex.org/W1991865867","https://openalex.org/W1992048975","https://openalex.org/W1993742172","https://openalex.org/W1995976925","https://openalex.org/W2000362479","https://openalex.org/W2002410732","https://openalex.org/W2005240718","https://openalex.org/W2006996074","https://openalex.org/W2007250290","https://openalex.org/W2008510086","https://openalex.org/W2016253390","https://openalex.org/W2016459259","https://openalex.org/W2017508812","https://openalex.org/W2024301675","https://openalex.org/W2024367381","https://openalex.org/W2025138357","https://openalex.org/W2027686496","https://openalex.org/W2031123547","https://openalex.org/W2033801757","https://openalex.org/W2036274324","https://openalex.org/W2039445898","https://openalex.org/W2040266344","https://openalex.org/W2042130821","https://openalex.org/W2042584344","https://openalex.org/W2042825771","https://openalex.org/W2043646282","https://openalex.org/W2046307206","https://openalex.org/W2047721998","https://openalex.org/W2054653938","https://openalex.org/W2054993296","https://openalex.org/W2057257609","https://openalex.org/W2063374921","https://openalex.org/W2068456278","https://openalex.org/W2068669952","https://openalex.org/W2072556964","https://openalex.org/W2076118496","https://openalex.org/W2076808220","https://openalex.org/W2078384542","https://openalex.org/W2081200884","https://openalex.org/W2088921403","https://openalex.org/W2096791952","https://openalex.org/W2099000660","https://openalex.org/W2100037084","https://openalex.org/W2101462909","https://openalex.org/W2112600997","https://openalex.org/W2113249117","https://openalex.org/W2121889667","https://openalex.org/W2122832461","https://openalex.org/W2134855648","https://openalex.org/W2143285612","https://openalex.org/W2144990030","https://openalex.org/W2158951763","https://openalex.org/W2220602474","https://openalex.org/W2260038117","https://openalex.org/W2261118883","https://openalex.org/W2262065180","https://openalex.org/W2336378782","https://openalex.org/W2404590204","https://openalex.org/W2416599074","https://openalex.org/W4297040010","https://openalex.org/W4313333817","https://openalex.org/W6663578514"],"related_works":["https://openalex.org/W7098742421","https://openalex.org/W2074699768","https://openalex.org/W2071033277","https://openalex.org/W86341414","https://openalex.org/W1561743635","https://openalex.org/W4247419207","https://openalex.org/W2345037133","https://openalex.org/W4211123467","https://openalex.org/W173023596","https://openalex.org/W2007508231"],"abstract_inverted_index":{"Wiskott-Aldrich":[0],"syndrome":[1],"(WAS)":[2],"is":[3,20,30],"an":[4,25,50],"X-linked":[5],"recessive":[6],"disorder":[7],"characterized":[8],"by":[9,22,135,145],"thrombocytopenia,":[10],"eczema,":[11],"and":[12,35,120],"a":[13,86],"progressive":[14,148],"deterioration":[15],"of":[16,37,53,61,72,117,123,138],"immune":[17,42],"function.":[18],"WAS":[19,45,67,80,98,151],"caused":[21],"mutations":[23],"in":[24,32,44,69,150],"intracellular":[26],"protein,":[27],"WASP,":[28],"that":[29,78,131],"involved":[31],"signal":[33],"transduction":[34],"regulation":[36],"actin":[38],"cytoskeleton":[39],"rearrangement.":[40],"Because":[41],"dysfunction":[43],"may":[46,140],"be":[47,141],"due":[48],"to":[49,59],"accelerated":[51,132],"destruction":[52,134],"lymphocytes,":[54],"we":[55],"examined":[56],"the":[57,70,115,121,147],"susceptibility":[58],"apoptosis":[60,84,119,139],"resting":[62],"primary":[63],"lymphocytes":[64,81,99],"isolated":[65],"from":[66],"patients":[68,152],"absence":[71],"exogenous":[73],"apoptogenic":[74],"stimulation.":[75],"We":[76],"found":[77],"unstimulated":[79,90],"underwent":[82],"spontaneous":[83,118,136],"at":[85],"greater":[87],"frequency":[88,116],"than":[89],"normal":[91],"lymphocytes.":[92],"Coincident":[93],"with":[94],"increased":[95],"apoptotic":[96],"susceptibility,":[97],"had":[100],"markedly":[101],"attenuated":[102],"Bcl-2":[103,124],"expression,":[104],"whereas":[105],"Bax":[106],"expression":[107,125],"did":[108],"not":[109],"differ.":[110],"A":[111],"negative":[112],"correlation":[113],"between":[114],"level":[122],"was":[126],"demonstrated.":[127],"These":[128],"data":[129],"indicate":[130],"lymphocyte":[133],"induction":[137],"one":[142],"pathogenic":[143],"mechanism":[144],"which":[146],"immunodeficiency":[149],"develops.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
