{"id":"https://openalex.org/W2417177366","doi":null,"title":"Cardiovascular effects of an antiarrhythmic aminosteroid ORG 6001 in the anesthetized pig.","display_name":"Cardiovascular effects of an antiarrhythmic aminosteroid ORG 6001 in the anesthetized pig.","publication_year":1976,"publication_date":"1976-01-01","ids":{"openalex":"https://openalex.org/W2417177366","mag":"2417177366","pmid":"https://pubmed.ncbi.nlm.nih.gov/1036951"},"language":"en","primary_location":{"id":"pmid:1036951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1036951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001645023","display_name":"Verdouw Pd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P D Verdouw","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072264327","display_name":"Remme Wj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W J Remme","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067747567","display_name":"Jacques Beaune","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Beaune","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059112280","display_name":"A. M. Rutteman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A M Rutteman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023174260","display_name":"FRANS HAGEMEIJER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Hagemeijer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.42718244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"8","first_page":"1558","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aminosteroids","display_name":"aminosteroids","score":0.8970000147819519},{"id":"https://openalex.org/keywords/antiarrhythmic-drugs","display_name":"antiarrhythmic drugs","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cardiovascular-effects","display_name":"cardiovascular effects","score":0.7110000252723694},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.7310000061988831},{"id":"https://openalex.org/keywords/negative-inotropic-effect","display_name":"negative inotropic effect","score":0.7549999952316284},{"id":"https://openalex.org/keywords/afterload","display_name":"afterload","score":0.7760000228881836},{"id":"https://openalex.org/keywords/filling-pressure","display_name":"filling pressure","score":0.75},{"id":"https://openalex.org/keywords/atrioventricular-conduction","display_name":"atrioventricular conduction","score":0.8190000057220459},{"id":"https://openalex.org/keywords/second-degree-av-block","display_name":"second-degree AV block","score":0.7990000247955322},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.8769999742507935},{"id":"https://openalex.org/keywords/anesthetized-pigs","display_name":"anesthetized pigs","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C155710745","wikidata":"https://www.wikidata.org/wiki/Q575278","display_name":"Inotrope","level":2,"score":0.6818970441818237},{"id":"https://openalex.org/C123576724","wikidata":"https://www.wikidata.org/wiki/Q1299082","display_name":"Afterload","level":3,"score":0.5970786809921265},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4900296926498413},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47632843255996704},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38764870166778564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3603307902812958},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.35681119561195374},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.27442029118537903}],"mesh":[{"descriptor_ui":"D000731","descriptor_name":"Androstanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015068","descriptor_name":"17-Ketosteroids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1036951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1036951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Journal Article"},{"id":"mag:2417177366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1036951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2273462997","https://openalex.org/W1980772485","https://openalex.org/W2034800329","https://openalex.org/W2053677612","https://openalex.org/W2024844834","https://openalex.org/W1971609482","https://openalex.org/W2059506685","https://openalex.org/W1984255286","https://openalex.org/W2068192540","https://openalex.org/W2033990162"],"abstract_inverted_index":{"The":[0],"hemodynamic":[1],"effects":[2],"of":[3,37,42,51,69,87,94,110],"3alpha-amino-5alpha-androstan-2beta-ol-17-one-hydrochloride":[4],"(ORG":[5],"6001),":[6],"an":[7],"aminosteroid":[8],"possessing":[9],"antiarrhythmic":[10],"properties,":[11],"were":[12,106],"studied":[13],"in":[14,35,131],"14":[15,96],"anesthetized":[16],"pigs.":[17],"ORG":[18,43,114],"6001":[19,115],"was":[20,28,57,63,74,83,99],"administered":[21],"i.v.":[22],"cumulatively":[23],"until":[24],"a":[25,132],"toxic":[26],"level":[27],"reached.":[29],"Doses":[30],"less":[31,126],"than":[32,127],"20mg/kg":[33],"had,":[34],"spite":[36],"the":[38,48,52,55,60,88,95,102,104],"negative":[39],"inotropic":[40],"properties":[41],"6001,":[44],"no":[45],"effect":[46],"on":[47],"pump":[49,89],"function":[50,90],"heart,":[53],"as":[54],"afterload":[56],"reduced":[58],"and":[59,76,91],"filling":[61],"pressure":[62],"not":[64],"significantly":[65],"altered.":[66],"After":[67],"administration":[68],"40":[70],"mg/kg":[71],"A-V":[72,79],"conduction":[73],"depressed":[75],"second":[77],"degree":[78],"block":[80],"appeared.":[81],"This":[82],"associated":[84],"with":[85],"deterioration":[86],"for":[92,145],"6":[93],"animals":[97],"this":[98],"fatal.":[100],"In":[101],"survivors,":[103],"alterations":[105],"reversible":[107],"after":[108],"cessation":[109],"drug":[111],"administration.":[112],"Since":[113],"has":[116],"been":[117],"shown":[118],"to":[119],"be":[120,142],"effective":[121],"against":[122],"arrhythmias":[123],"at":[124],"doses":[125],"20":[128],"mg/kg,":[129],"though":[130],"different":[133],"species":[134],"(dog),":[135],"it":[136,140],"seems":[137],"likely":[138],"that":[139],"can":[141],"used":[143],"safely":[144],"antiarrythmic":[146],"treatment.":[147]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
