{"id":"https://openalex.org/W2417075253","doi":"https://doi.org/10.1152/ajprenal.1989.256.5.f901","title":"Cystine and lysine reabsorption in the isolated perfused rat kidney","display_name":"Cystine and lysine reabsorption in the isolated perfused rat kidney","publication_year":1989,"publication_date":"1989-05-01","ids":{"openalex":"https://openalex.org/W2417075253","doi":"https://doi.org/10.1152/ajprenal.1989.256.5.f901","mag":"2417075253","pmid":"https://pubmed.ncbi.nlm.nih.gov/2566279"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.1989.256.5.f901","doi":"https://doi.org/10.1152/ajprenal.1989.256.5.f901","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.1989.256.5.f901","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110298695","display_name":"K. A. W. Roby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. A. Roby","raw_affiliation_strings":["Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113556670","display_name":"Stanton Segal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Segal","raw_affiliation_strings":["Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1335321130"],"apc_list":null,"apc_paid":null,"fwci":0.1942,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.42684674,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"256","issue":"5","first_page":"F901","last_page":"F908"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-tubular-transport","display_name":"renal tubular transport","score":0.9390000104904175},{"id":"https://openalex.org/keywords/saturable-transport","display_name":"saturable transport","score":0.628000020980835},{"id":"https://openalex.org/keywords/dibasic-amino-acids","display_name":"dibasic amino acids","score":0.902999997138977},{"id":"https://openalex.org/keywords/at-125","display_name":"AT-125","score":0.9380000233650208},{"id":"https://openalex.org/keywords/glutathione-degradation","display_name":"glutathione degradation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/brush-border-membrane","display_name":"brush border membrane","score":0.7289999723434448},{"id":"https://openalex.org/keywords/isolated-perfused-kidney","display_name":"isolated perfused kidney","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.8068084716796875},{"id":"https://openalex.org/C2777608289","wikidata":"https://www.wikidata.org/wiki/Q408626","display_name":"Cystine","level":4,"score":0.7578388452529907},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.7325208187103271},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5383085012435913},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.48052987456321716},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4564083516597748},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45145711302757263},{"id":"https://openalex.org/C161457703","wikidata":"https://www.wikidata.org/wiki/Q3317402","display_name":"Renal physiology","level":3,"score":0.4359711706638336},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3658772110939026},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3186650574207306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29240745306015015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18452760577201843},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.07257038354873657},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.03951495885848999}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003553","descriptor_name":"Cystine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005723","descriptor_name":"gamma-Glutamyltransferase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajprenal.1989.256.5.f901","doi":"https://doi.org/10.1152/ajprenal.1989.256.5.f901","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.1989.256.5.f901","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmid:2566279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2566279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1498869307","https://openalex.org/W2055846917","https://openalex.org/W2887803636","https://openalex.org/W1997565915","https://openalex.org/W984633442","https://openalex.org/W2886652865","https://openalex.org/W2037604964","https://openalex.org/W2034462313","https://openalex.org/W2408781714","https://openalex.org/W2170559202"],"abstract_inverted_index":{"Renal":[0],"tubular":[1,77],"reabsorption":[2],"of":[3,29,80,101,108,123,150,153],"cystine":[4,84,102,109,116,135,147,154],"and":[5,24,33,127],"lysine":[6,69],"were":[7],"studied":[8],"in":[9,20,25,60,120],"the":[10,17,46,63,89,99,121,128,140,151],"isolated":[11],"perfused":[12],"rat":[13],"kidney":[14],"to":[15,145],"bridge":[16],"gap":[18],"between":[19],"vivo":[21],"clearance":[22],"studies,":[23],"vitro":[26],"transport":[27,42,55],"studies":[28],"tubule":[30],"fragments,":[31],"cells,":[32],"brush-border":[34],"membranes.":[35],"Lysine":[36],"was":[37,49,58,72,86,97,105],"reabsorped":[38],"by":[39,45,52,62],"a":[40,53,76],"saturable":[41,54],"system":[43],"shared":[44,59],"dibasics.":[47],"Cystine":[48],"also":[50],"reabsorbed":[51],"system,":[56],"which":[57],"part":[61],"dibasics":[64],"(maximum":[65],"inhibition":[66],"30%).":[67],"The":[68,83,111],"threshold":[70],"(Fmin)":[71],"0.9":[73],"mumol.min-1.g-1,":[74],"with":[75],"maximum":[78],"(TM)":[79],"2.4":[81],"mumol.min-1.g-1.":[82],"Fmin":[85],"0.06":[87],"mumol.min-1.g-1;":[88],"TM":[90],"could":[91],"not":[92],"be":[93],"estimated":[94],"because":[95],"it":[96],"above":[98],"limit":[100],"solubility.":[103],"There":[104],"no":[106],"evidence":[107],"\"secretion.\"":[110],"gamma-glutamyltransferase":[112],"inhibitor,":[113],"AT-125,":[114],"decreased":[115],"excretion,":[117],"but":[118,156],"only":[119,157],"presence":[122],"glutathione,":[124],"glycine,":[125],"glutamate,":[126],"diabasic":[129],"amino":[130],"acids.":[131],"This":[132],"suggests":[133],"that":[134],"from":[136],"glutathione":[137],"degradation":[138],"at":[139],"brush":[141],"border":[142],"may":[143],"contribute":[144],"urinary":[146],"(an":[148],"explanation":[149],"phenomenon":[152],"secretion),":[155],"under":[158],"certain":[159],"conditions.":[160]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}