{"id":"https://openalex.org/W2416818878","doi":null,"title":"Alterations in human linker histone-DNA binding in the presence of aluminum salts in vitro and in Alzheimer's disease.","display_name":"Alterations in human linker histone-DNA binding in the presence of aluminum salts in vitro and in Alzheimer's disease.","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2416818878","mag":"2416818878","pmid":"https://pubmed.ncbi.nlm.nih.gov/3601241"},"language":"en","primary_location":{"id":"pmid:3601241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3601241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotoxicology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034934480","display_name":"Walter J. Lukiw","orcid":"https://orcid.org/0000-0001-5500-4402","observed_orcids":["https://orcid.org/0000-0001-5500-4402"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W J Lukiw","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111481112","display_name":"Theo P.A. Kruck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T P Kruck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111811664","display_name":"Donald R. Crapper McLachlan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D R McLachlan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1383,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.88213474,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"8","issue":"2","first_page":"291","last_page":"301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.1264999955892563,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.03739999979734421,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8899999856948853},{"id":"https://openalex.org/keywords/histone-h1","display_name":"histone H1","score":0.8140000104904175},{"id":"https://openalex.org/keywords/aluminum-salts","display_name":"aluminum salts","score":0.6510000228881836},{"id":"https://openalex.org/keywords/aluminum-lactate","display_name":"aluminum lactate","score":0.9309999942779541},{"id":"https://openalex.org/keywords/histone-dna-interactions","display_name":"histone-DNA interactions","score":0.8059999942779541},{"id":"https://openalex.org/keywords/chromatin-condensation","display_name":"chromatin condensation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/sodium-chloride-extraction","display_name":"sodium chloride extraction","score":0.7559999823570251},{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.9430000185966492},{"id":"https://openalex.org/keywords/aluminum-chelation","display_name":"aluminum chelation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/nuclear-chromatin","display_name":"nuclear chromatin","score":0.3880000114440918},{"id":"https://openalex.org/keywords/ionic-strength","display_name":"ionic strength","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7863730192184448},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7410215139389038},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.686839759349823},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6622104644775391},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6372071504592896},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.6079379916191101},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.6008115410804749},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5541107058525085},{"id":"https://openalex.org/C193646685","wikidata":"https://www.wikidata.org/wiki/Q1826830","display_name":"Linker DNA","level":5,"score":0.5299649834632874},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.5043812990188599},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44850292801856995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2353660762310028},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.20078453421592712},{"id":"https://openalex.org/C101152365","wikidata":"https://www.wikidata.org/wiki/Q838135","display_name":"Histone H1","level":4,"score":0.15464282035827637},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1171737015247345},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000535","descriptor_name":"Aluminum","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000535","descriptor_name":"Aluminum","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012492","descriptor_name":"Salts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3601241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3601241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotoxicology","raw_type":"Journal Article"},{"id":"mag:2416818878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3601241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2059435808","https://openalex.org/W2089758805","https://openalex.org/W2029098111","https://openalex.org/W2010369679","https://openalex.org/W2015533773","https://openalex.org/W2013329925","https://openalex.org/W2001739283","https://openalex.org/W1994035522","https://openalex.org/W1984690993","https://openalex.org/W2007823301"],"abstract_inverted_index":{"Sodium":[0],"cations":[1],"were":[2],"employed":[3],"to":[4,43,88],"electrostatically":[5],"displace":[6],"chromosomal":[7],"proteins":[8],"from":[9],"DNA.":[10],"Increasing":[11],"the":[12,45,96,114],"ambient":[13],"ionic":[14],"concentration":[15],"resulted":[16],"in":[17,38,51,59,66,80,95,109,113,119],"a":[18],"characteristic":[19],"dissociation":[20],"pattern":[21],"of":[22,32,36,47,49,98,116],"chromatin":[23,50],"which":[24],"was":[25],"analyzed":[26],"on":[27],"polyacrylamide":[28],"gels.":[29],"This":[30],"method":[31],"sodium":[33],"chloride":[34],"extraction":[35],"nuclei":[37,57,61],"vitro":[39],"has":[40],"been":[41],"used":[42],"investigate":[44],"state":[46],"compaction":[48],"normal":[52],"and":[53,58,92,102,112],"Alzheimer":[54],"affected":[55],"neocortical":[56],"control":[60],"treated":[62],"with":[63],"aluminum":[64,84,117],"lactate":[65],"vitro.":[67,120],"Our":[68],"results":[69],"indicate":[70],"that":[71],"by":[72,90],"employing":[73],"specific":[74],"chelating":[75],"agents":[76],"such":[77],"as":[78],"desferrioxamine":[79],"vitro,":[81],"nuclear":[82],"bound":[83],"is":[85],"particularly":[86],"resistant":[87],"removal":[89],"chelation":[91],"an":[93],"increase":[94],"affinity":[97],"linker":[99],"histones":[100],"H1":[101,103],"degree":[104],"for":[105],"DNA":[106],"occurs":[107],"both":[108],"Alzheimer's":[110],"disease":[111],"presence":[115],"salts":[118]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}