{"id":"https://openalex.org/W2416788367","doi":null,"title":"Apoptosis and proliferation of endothelial cells in early atherosclerotic lesions: possible role of oxidised LDL.","display_name":"Apoptosis and proliferation of endothelial cells in early atherosclerotic lesions: possible role of oxidised LDL.","publication_year":2002,"publication_date":"2002-10-01","ids":{"openalex":"https://openalex.org/W2416788367","mag":"2416788367","pmid":"https://pubmed.ncbi.nlm.nih.gov/12616810"},"language":"en","primary_location":{"id":"pmid:12616810","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12616810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition, metabolism, and cardiovascular diseases : NMCD","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000214404","display_name":"Giuseppe Danilo Norata","orcid":"https://orcid.org/0000-0002-6081-1257","observed_orcids":["https://orcid.org/0000-0002-6081-1257"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G D Norata","raw_affiliation_strings":["Department of Pharmacological Sciences, University of Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University of Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044585823","display_name":"L. Tonti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Tonti","raw_affiliation_strings":["University of Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milan","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014916280","display_name":"Paola Roma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P Roma","raw_affiliation_strings":["University of Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milan","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091523473","display_name":"Alberico Luigi Catapano","orcid":"https://orcid.org/0000-0002-7593-2094","observed_orcids":["https://orcid.org/0000-0002-7593-2094"]},"institutions":[{"id":"https://openalex.org/I4210094922","display_name":"MultiMedica","ror":"https://ror.org/01h8ey223","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094922","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A L Catapano","raw_affiliation_strings":["IRCCS Multimedica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Multimedica","institution_ids":["https://openalex.org/I4210094922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.054,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.75645403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"12","issue":"5","first_page":"297","last_page":"305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-cell-apoptosis","display_name":"endothelial cell apoptosis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.8190000057220459},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/aortic-arch","display_name":"aortic arch","score":0.6420000195503235},{"id":"https://openalex.org/keywords/cholesterol-fed-rabbits","display_name":"cholesterol-fed rabbits","score":0.7089999914169312},{"id":"https://openalex.org/keywords/smooth-muscle-cells","display_name":"smooth muscle cells","score":0.7839999794960022},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9819999933242798},{"id":"https://openalex.org/keywords/fas","display_name":"Fas","score":0.8859999775886536},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9890000224113464},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9380000233650208},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9430000185966492},{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.8690000176429749},{"id":"https://openalex.org/keywords/tunel-assay","display_name":"TUNEL","score":0.8529999852180481},{"id":"https://openalex.org/keywords/intimal-thickening","display_name":"intimal thickening","score":0.7879999876022339},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.765999972820282},{"id":"https://openalex.org/keywords/apoptosis-signaling-pathway","display_name":"apoptosis signaling","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8054378032684326},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.7997323870658875},{"id":"https://openalex.org/C34688535","wikidata":"https://www.wikidata.org/wiki/Q418732","display_name":"Proliferating cell nuclear antigen","level":3,"score":0.7386911511421204},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5489344596862793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.519961953163147},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43942829966545105},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3914036750793457},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37721824645996094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3227352499961853},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3108900785446167},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26586130261421204},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2037830352783203},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18178007006645203},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.100454181432724}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002791","descriptor_name":"Cholesterol, Dietary","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12616810","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12616810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition, metabolism, and cardiovascular diseases : NMCD","raw_type":"Journal Article"},{"id":"mag:2416788367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12616810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1980288770","https://openalex.org/W2161543197","https://openalex.org/W2000271267","https://openalex.org/W945388266","https://openalex.org/W2049396262","https://openalex.org/W2093961243","https://openalex.org/W2171363744","https://openalex.org/W1975370063","https://openalex.org/W2027356789","https://openalex.org/W2119529702"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,85],"AIM:":[2],"Evidence":[3],"for":[4,103,127,153,341],"apoptosis":[5,35],"has":[6,206],"been":[7,207],"found":[8],"in":[9,46,59,66,78,81,130,143,194,201,240,253,264,281,290,300,303,333],"advanced":[10],"atherosclerotic":[11,79,161],"lesions,":[12],"but":[13],"the":[14,34,60,154,169,182,195,202,221,234,241,265,271,282,297,301,342],"factors":[15],"triggering":[16],"it":[17,205],"are":[18,25],"poorly":[19],"understood.":[20],"Oxidised":[21],"low-density":[22],"lipoproteins":[23],"(LDLs)":[24],"cytotoxic":[26],"to":[27,54,187,228,270],"a":[28,94,98],"variety":[29],"of":[30,36,50,63,109,171,177,184,223,246,292,321,327],"cells":[31,39,45,77,248,308],"and":[32,43,68,114,123,138,152,168,173,197,236,258,267,278,295,306,324,335],"induce":[33],"smooth":[37],"muscle":[38],"(SMC),":[40],"fibroblast,":[41],"macrophages":[42,122,277],"endothelial":[44,120,343],"vitro.":[47],"The":[48,106,141,175,243],"aim":[49],"this":[51],"study":[52],"was":[53,112,190,249],"investigate":[55],"apoptotic":[56,76,131,178,247,323],"cell":[57,156],"death":[58],"early":[61],"phases":[62],"aortic":[64,107],"atherosclerosis":[65],"rabbits,":[67],"whether":[69],"oxidised":[70,124,285,328],"LDLs":[71,125,329],"colocalize":[72],"ex":[73,318],"vivo":[74,319],"with":[75,116,148,276],"lesions":[80,162,196],"cholesterol-fed":[82],"rabbits.":[83],"METHODS":[84],"RESULTS:":[86],"Male":[87],"albino":[88],"New":[89],"Zealand":[90],"rabbits":[91],"were":[92,146,163,261,288,309],"fed":[93],"standard":[95],"diet":[96,99],"or":[97,126],"containing":[100],"1.2%":[101],"cholesterol":[102],"60":[104],"days.":[105],"arch":[108],"each":[110],"animal":[111],"sectioned":[113],"stained":[115,147],"antibodies":[117],"against":[118],"SMC,":[119],"cells,":[121,179,225],"proteins":[128],"involved":[129],"pathways":[132],"such":[133],"as":[134,181,317,330],"Fas,":[135,256],"Bax,":[136],"Bcl2,":[137],"caspase":[139],"3.":[140],"nuclei":[142,186,189,210],"adjacent":[144],"sections":[145],"Hoechst":[149],"33258,":[150],"TUNEL":[151,217,305],"proliferating":[155,325],"nuclear":[157],"antigen":[158],"(PCNA).":[159],"Early":[160],"characterised":[164],"by":[165,350],"intimal":[166],"thickening":[167],"presence":[170],"SMC":[172,268,279],"macrophages.":[174],"percentage":[176,222,245],"calculated":[180],"ratio":[183],"TUNEL-positive":[185],"total":[188],"32.6":[191],"+/-":[192,199,231,238],"3.73%":[193],"55.9":[198],"2.36%":[200],"endothelium.":[203],"As":[204],"reported":[208],"that":[209,345],"undergoing":[211],"active":[212],"gene":[213],"transcription":[214],"can":[215,346],"be":[216,229,315,347],"positive,":[218],"we":[219],"evaluated":[220],"PCNA-positive":[224,307],"which":[226,304],"proved":[227],"45.2":[230],"4.68%":[232],"along":[233,296],"endothelium":[235,266],"22.3":[237],"2.7%":[239],"intima.":[242],"true":[244],"therefore":[250],"about":[251],"10%":[252],"both":[254],"cases.":[255],"Bax":[257],"caspase3":[259],"signals":[260],"mainly":[262,299],"located":[263],"proximal":[269],"lumen,":[272],"whereas":[273],"Bcl2":[274],"colocalized":[275],"deeper":[280],"lesions.":[283],"Abundant":[284],"LDL":[286],"epitopes":[287],"detected":[289],"areas":[291,302],"lipid":[293],"accumulation":[294],"endothelium,":[298],"localised.":[310],"CONCLUSIONS:":[311],"Our":[312],"findings":[313],"may":[314,336],"taken":[316],"indications":[320],"an":[322],"role":[326],"previously":[331],"shown":[332],"vitro,":[334],"at":[337],"least":[338],"partially":[339],"account":[340],"dysfunction":[344],"rapidly":[348],"induced":[349],"hypercholesterolemia.":[351]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
