{"id":"https://openalex.org/W2416664751","doi":null,"title":"New Perspectives in Cancer Therapy: The Biotin-Antitumor Molecule","display_name":"New Perspectives in Cancer Therapy: The Biotin-Antitumor Molecule","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2416664751","mag":"2416664751"},"language":"en","primary_location":{"id":"mag:2416664751","doi":null,"is_oa":false,"landing_page_url":"https://www.omicsonline.org/open-access/new-perspectives-in-cancer-therapy-the-biotinantitumor-molecule-conjugates-2161-0444.S1-004.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081720047","display_name":"Delia Mandracchia","orcid":"https://orcid.org/0000-0002-7101-013X","observed_orcids":["https://orcid.org/0000-0002-7101-013X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Delia Mandracchia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013533656","display_name":"Simona Collina","orcid":"https://orcid.org/0000-0002-2954-7558","observed_orcids":["https://orcid.org/0000-0002-2954-7558"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simona Collina","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2954-7558","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079022354","display_name":"Marta Rui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Rui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5052838173","display_name":"Daniela Rossi","orcid":"https://orcid.org/0000-0002-2458-3728","observed_orcids":["https://orcid.org/0000-0002-2458-3728"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela Rossi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2458-3728","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1121,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4088433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biotin","display_name":"biotin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.5979999899864197},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cytotoxic-drugs","display_name":"cytotoxic drugs","score":0.6069999933242798},{"id":"https://openalex.org/keywords/drug-selectivity","display_name":"drug selectivity","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6492477059364319},{"id":"https://openalex.org/C2778204606","wikidata":"https://www.wikidata.org/wiki/Q181354","display_name":"Biotin","level":2,"score":0.5231436491012573},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5109073519706726},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5001914501190186},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.4398636519908905},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.41575801372528076},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38483741879463196},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3681616485118866},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32404905557632446},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15938538312911987},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12873244285583496}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2416664751","doi":null,"is_oa":false,"landing_page_url":"https://www.omicsonline.org/open-access/new-perspectives-in-cancer-therapy-the-biotinantitumor-molecule-conjugates-2161-0444.S1-004.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W190165186","https://openalex.org/W1552940397","https://openalex.org/W1938548874","https://openalex.org/W1963965930","https://openalex.org/W1964683306","https://openalex.org/W1965244738","https://openalex.org/W1967018540","https://openalex.org/W1967393143","https://openalex.org/W1968803367","https://openalex.org/W1970248241","https://openalex.org/W1971579914","https://openalex.org/W1972132259","https://openalex.org/W1975065137","https://openalex.org/W1975556125","https://openalex.org/W1976194314","https://openalex.org/W1978320804","https://openalex.org/W1978556565","https://openalex.org/W1983342786","https://openalex.org/W1986446988","https://openalex.org/W1988893380","https://openalex.org/W1999142756","https://openalex.org/W2003062295","https://openalex.org/W2004224153","https://openalex.org/W2010183849","https://openalex.org/W2012216006","https://openalex.org/W2013051417","https://openalex.org/W2013723086","https://openalex.org/W2019949956","https://openalex.org/W2020085931","https://openalex.org/W2023376720","https://openalex.org/W2023956684","https://openalex.org/W2032710530","https://openalex.org/W2033325359","https://openalex.org/W2034406895","https://openalex.org/W2035188342","https://openalex.org/W2043002859","https://openalex.org/W2043610941","https://openalex.org/W2047342341","https://openalex.org/W2048164597","https://openalex.org/W2048208243","https://openalex.org/W2056906192","https://openalex.org/W2059807175","https://openalex.org/W2059829059","https://openalex.org/W2060597886","https://openalex.org/W2060677198","https://openalex.org/W2063825051","https://openalex.org/W2074868392","https://openalex.org/W2082026141","https://openalex.org/W2082943688","https://openalex.org/W2086415594","https://openalex.org/W2087700426","https://openalex.org/W2093855538","https://openalex.org/W2095412415","https://openalex.org/W2096526911","https://openalex.org/W2099564459","https://openalex.org/W2105633165","https://openalex.org/W2106926141","https://openalex.org/W2108373310","https://openalex.org/W2109040614","https://openalex.org/W2112442437","https://openalex.org/W2132953654","https://openalex.org/W2164193797","https://openalex.org/W2165044430","https://openalex.org/W2168618337","https://openalex.org/W2172164746","https://openalex.org/W2223721927","https://openalex.org/W2320707582","https://openalex.org/W2322474793"],"related_works":["https://openalex.org/W2321810168","https://openalex.org/W3119619206","https://openalex.org/W4405037415","https://openalex.org/W2782175804","https://openalex.org/W858600869","https://openalex.org/W1894195601","https://openalex.org/W2324483495","https://openalex.org/W6887945981","https://openalex.org/W2558937881","https://openalex.org/W2363497793"],"abstract_inverted_index":{"Chemotherapy":[0],"is":[1,110],"still":[2],"the":[3,23,42,45,48,65,85,100,119],"first-line":[4],"treatment":[5],"of":[6,67,84,107,121],"cancer,":[7],"even":[8],"if":[9],"drugs":[10,40,69],"currently":[11],"used":[12],"in":[13,79,118],"therapy":[14],"generally":[15],"possess":[16],"high":[17,89],"toxicity":[18],"and":[19,61],"poor":[20],"selectivity.":[21],"In":[22],"last":[24],"two":[25],"decades":[26],"several":[27],"efforts":[28],"have":[29],"been":[30],"made":[31],"to":[32,41,70,74,91,98,111],"overcome":[33],"these":[34],"drawbacks":[35],"by":[36],"specifically":[37,80],"carrying":[38],"anticancer":[39,127],"tumors.":[43],"Among":[44,94],"different":[46],"approaches,":[47],"so":[49],"called":[50],"vitamin-":[51],"mediated":[52],"drug":[53,87],"targeting":[54,103],"has":[55],"recently":[56],"emerged":[57],"as":[58],"a":[59],"novel":[60],"valuable":[62],"strategy.":[63],"Indeed,":[64],"linkage":[66],"cytotoxic":[68],"selected":[71],"vitamins,":[72,95],"leading":[73],"vitamin-drug":[75],"conjugates,":[76],"would":[77],"result":[78],"delivering":[81],"great":[82],"amounts":[83],"targeted":[86],"at":[88],"doses":[90],"cancer":[92],"cells.":[93],"biotin":[96,122],"seems":[97],"be":[99],"most":[101],"promising":[102],"agent.":[104],"The":[105],"aim":[106],"this":[108],"review":[109],"get":[112],"an":[113],"overview":[114],"on":[115],"recent":[116],"success":[117],"conjugation":[120],"with":[123,126],"molecules":[124],"endowed":[125],"properties.":[128]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}