{"id":"https://openalex.org/W2416632315","doi":"https://doi.org/10.1152/ajpheart.1998.274.3.h965","title":"Induction ofHSP 32gene in hypoxic cardiomyocytes is attenuated by treatment withN-acetyl- l -cysteine","display_name":"Induction ofHSP 32gene in hypoxic cardiomyocytes is attenuated by treatment withN-acetyl- l -cysteine","publication_year":1998,"publication_date":"1998-03-01","ids":{"openalex":"https://openalex.org/W2416632315","doi":"https://doi.org/10.1152/ajpheart.1998.274.3.h965","mag":"2416632315","pmid":"https://pubmed.ncbi.nlm.nih.gov/9530210"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1998.274.3.h965","doi":"https://doi.org/10.1152/ajpheart.1998.274.3.h965","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1998.274.3.h965","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109408686","display_name":"Darrell R. Borger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. R. Borger","raw_affiliation_strings":["Department of Exercise Science, Laboratory of Exercise Molecular Biology, University of South Carolina, Columbia, South Carolina 29208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Science, Laboratory of Exercise Molecular Biology, University of South Carolina, Columbia, South Carolina 29208","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010873610","display_name":"David A. Essig","orcid":"https://orcid.org/0000-0001-5585-0115","observed_orcids":["https://orcid.org/0000-0001-5585-0115"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. A. Essig","raw_affiliation_strings":["Department of Exercise Science, Laboratory of Exercise Molecular Biology, University of South Carolina, Columbia, South Carolina 29208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Science, Laboratory of Exercise Molecular Biology, University of South Carolina, Columbia, South Carolina 29208","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I155781252"],"apc_list":null,"apc_paid":null,"fwci":1.3627,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.81257348,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"274","issue":"3","first_page":"H965","last_page":"H973"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8130000233650208},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9190000295639038},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8209999799728394},{"id":"https://openalex.org/keywords/heme-oxygenase-2","display_name":"heme oxygenase-2","score":0.8690000176429749},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.8479999899864197},{"id":"https://openalex.org/keywords/redox-signaling","display_name":"redox signaling","score":0.8309999704360962},{"id":"https://openalex.org/keywords/gene-induction","display_name":"gene induction","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.8264907598495483},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6727554798126221},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6201661229133606},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.6114379167556763},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5998063683509827},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.556846022605896},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5001645088195801},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49339428544044495},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.48141881823539734},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4775853455066681},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.4228877127170563},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3832828402519226},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33304911851882935},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28514760732650757},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.23780229687690735},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16564083099365234},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010105","descriptor_name":"Oxygenases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010105","descriptor_name":"Oxygenases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010105","descriptor_name":"Oxygenases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.1998.274.3.h965","doi":"https://doi.org/10.1152/ajpheart.1998.274.3.h965","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1998.274.3.h965","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:9530210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9530210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.49000000953674316,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1559821198","https://openalex.org/W1582375112","https://openalex.org/W1964037605","https://openalex.org/W1965404346","https://openalex.org/W1966502113","https://openalex.org/W1966582616","https://openalex.org/W1980802767","https://openalex.org/W1982260690","https://openalex.org/W1985582672","https://openalex.org/W1993608966","https://openalex.org/W1994087300","https://openalex.org/W1997207051","https://openalex.org/W2000254823","https://openalex.org/W2022560636","https://openalex.org/W2032327442","https://openalex.org/W2036391083","https://openalex.org/W2042773901","https://openalex.org/W2049587547","https://openalex.org/W2051105332","https://openalex.org/W2054001959","https://openalex.org/W2055655700","https://openalex.org/W2059989280","https://openalex.org/W2060262474","https://openalex.org/W2081635255","https://openalex.org/W2082289476","https://openalex.org/W2087516645","https://openalex.org/W2108916224","https://openalex.org/W2130933110","https://openalex.org/W2144634347","https://openalex.org/W2198443757","https://openalex.org/W2300177286","https://openalex.org/W2395090824","https://openalex.org/W2401475254","https://openalex.org/W2471178446"],"related_works":["https://openalex.org/W1603801708","https://openalex.org/W2024696643","https://openalex.org/W2128120260","https://openalex.org/W4200044645","https://openalex.org/W2006864593","https://openalex.org/W2062493069","https://openalex.org/W1521258655","https://openalex.org/W2043583102","https://openalex.org/W2002217214","https://openalex.org/W2065101979"],"abstract_inverted_index":{"Increased":[0],"synthesis":[1],"of":[2,11,63,115,127,157,182,186],"stress":[3,23,28],"proteins":[4],"may":[5,161],"enhance":[6],"myocardial":[7],"viability":[8],"during":[9,134,170],"periods":[10],"low":[12],"oxygen":[13],"delivery.":[14],"Our":[15],"purpose":[16],"was":[17,33,119],"to":[18,54,60,75,98,110,163],"determine":[19],"if":[20],"the":[21,132,137,183,187],"oxidative":[22],"protein":[24,29,95,144,160],"heme":[25,116],"oxygenase-1":[26],"[heat":[27],"32":[30,83,94,107,141,159,189],"(HSP":[31],"32)]":[32],"induced":[34],"in":[35,81,92,131,139,168],"hypoxic":[36,124,184],"cardiomyocytes":[37,169],"and":[38,85,143,172],"whether":[39],"this":[40],"induction":[41,156,185],"might":[42],"be":[43],"mediated":[44],"by":[45,121,146],"a":[46,56,86,111,174,180],"redox-sensitive":[47,175],"mechanism.":[48],"Primary":[49],"rat":[50],"neonatal":[51],"cardiomyocytes,":[52],"cultured":[53],"express":[55],"tissuelike":[57],"phenotype,":[58],"responded":[59],"12":[61],"h":[62,104],"hypoxia":[64,135,150,171],"(<":[65],"0.5%":[66],"ambient":[67],"oxygen)":[68],"with":[69,149],"an":[70,164],"approximately":[71],"fivefold":[72],"(range":[73],"3-":[74],"7.5-fold;":[76],"P":[77],"<":[78,89],"0.05)":[79,90],"increase":[80,91,138],"HSP":[82,93,106,140,158,188],"mRNA":[84,108,118,142],"threefold":[87],"(P":[88],"content.":[96],"Exposure":[97],"80":[99],"microM":[100],"H2O2":[101,122],"for":[102],"3":[103],"increased":[105],"content":[109],"similar":[112],"extent.":[113],"Expression":[114],"oxygenase-2":[117],"unaffected":[120],"or":[123],"treatments.":[125],"Inclusion":[126],"20":[128],"mM":[129],"N-acetyl-L-cysteine":[130],"medium":[133],"reduced":[136],"expression":[145],"25.50%":[147],"compared":[148],"alone.":[151],"The":[152],"data":[153],"suggest":[154],"that":[155,173],"lead":[162],"improved":[165],"antioxidant":[166],"defense":[167],"pathway":[176],"mediates":[177],"at":[178],"least":[179],"portion":[181],"gene.":[190]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
