{"id":"https://openalex.org/W2416622707","doi":"https://doi.org/10.1248/yakushi1947.106.1_90","title":"Effects of Nicergoline on Cerebral Energy Metabolism in Normal Mice","display_name":"Effects of Nicergoline on Cerebral Energy Metabolism in Normal Mice","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W2416622707","doi":"https://doi.org/10.1248/yakushi1947.106.1_90","mag":"2416622707","pmid":"https://pubmed.ncbi.nlm.nih.gov/3009777"},"language":"ja","primary_location":{"id":"doi:10.1248/yakushi1947.106.1_90","doi":"https://doi.org/10.1248/yakushi1947.106.1_90","is_oa":true,"landing_page_url":"https://doi.org/10.1248/yakushi1947.106.1_90","pdf_url":"https://www.jstage.jst.go.jp/article/yakushi1947/106/1/106_1_90/_pdf","source":{"id":"https://openalex.org/S2764386467","display_name":"YAKUGAKU ZASSHI","issn_l":"0031-6903","issn":["0031-6903","1347-5231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"YAKUGAKU ZASSHI","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/yakushi1947/106/1/106_1_90/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111848551","display_name":"Keiichi SHINTOMI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KEIICHI SHINTOMI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055615526","display_name":"Kenichi YOSHIMOTO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KENICHI YOSHIMOTO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007102090","display_name":"YORI OGAWA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YORI OGAWA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079975912","display_name":"Tadashi ITAKURA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"TADASHI ITAKURA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072625661","display_name":"Tomiko FUKUSHIMA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"TOMIKO FUKUSHIMA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"MAMORU MATSUMOTO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MAMORU MATSUMOTO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102192118","display_name":"Yuzo Matsuoka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YUZO MATSUOKA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024119860","display_name":"Ryuichi Ishida","orcid":"https://orcid.org/0000-0003-1012-2784","observed_orcids":["https://orcid.org/0000-0003-1012-2784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RYUICHI ISHIDA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"106","issue":"1","first_page":"90","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicergoline","display_name":"nicergoline","score":1.0},{"id":"https://openalex.org/keywords/brain-energy-metabolism","display_name":"brain energy metabolism","score":0.8669999837875366},{"id":"https://openalex.org/keywords/dihydroergotoxine","display_name":"dihydroergotoxine","score":0.949999988079071},{"id":"https://openalex.org/keywords/phosphocreatine","display_name":"phosphocreatine","score":0.8539999723434448},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.6169999837875366},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":1.0},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.6269999742507935},{"id":"https://openalex.org/keywords/brain-glycogen","display_name":"brain glycogen","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase","display_name":"cytochrome c oxidase","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cerebral-circulation","display_name":"cerebral circulation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/normal-mice","display_name":"normal mice","score":0.3070000112056732}],"concepts":[{"id":"https://openalex.org/C2779896295","wikidata":"https://www.wikidata.org/wiki/Q223600","display_name":"Creatine","level":2,"score":0.6390266418457031},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5782230496406555},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.5347297191619873},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.511246919631958},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44574958086013794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44535309076309204},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4402751326560974},{"id":"https://openalex.org/C123249941","wikidata":"https://www.wikidata.org/wiki/Q306116","display_name":"Cytochrome c oxidase","level":3,"score":0.41621652245521545},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30185359716415405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2061038315296173},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.09967514872550964}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004873","descriptor_name":"Ergolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009530","descriptor_name":"Nicergoline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/yakushi1947.106.1_90","doi":"https://doi.org/10.1248/yakushi1947.106.1_90","is_oa":true,"landing_page_url":"https://doi.org/10.1248/yakushi1947.106.1_90","pdf_url":"https://www.jstage.jst.go.jp/article/yakushi1947/106/1/106_1_90/_pdf","source":{"id":"https://openalex.org/S2764386467","display_name":"YAKUGAKU ZASSHI","issn_l":"0031-6903","issn":["0031-6903","1347-5231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"YAKUGAKU ZASSHI","raw_type":"journal-article"},{"id":"pmid:3009777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3009777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","raw_type":"English Abstract"}],"best_oa_location":{"id":"doi:10.1248/yakushi1947.106.1_90","doi":"https://doi.org/10.1248/yakushi1947.106.1_90","is_oa":true,"landing_page_url":"https://doi.org/10.1248/yakushi1947.106.1_90","pdf_url":"https://www.jstage.jst.go.jp/article/yakushi1947/106/1/106_1_90/_pdf","source":{"id":"https://openalex.org/S2764386467","display_name":"YAKUGAKU ZASSHI","issn_l":"0031-6903","issn":["0031-6903","1347-5231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"YAKUGAKU ZASSHI","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2416622707.pdf","grobid_xml":"https://content.openalex.org/works/W2416622707.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1966767674","https://openalex.org/W2036367775","https://openalex.org/W2404910971","https://openalex.org/W2036589420","https://openalex.org/W2152171397","https://openalex.org/W2047053311","https://openalex.org/W75202094","https://openalex.org/W1998264209","https://openalex.org/W2149349456","https://openalex.org/W2400721659"],"abstract_inverted_index":{"Effects":[0],"of":[1,21,41,46,56,62,79,128,149],"nicergoline,":[2],"a":[3,139],"cerebral":[4,10,120,146],"circulation":[5],"and":[6,31,49,52,81,89,94,104,130],"metabolism":[7,12,148],"ameliorator,":[8],"on":[9,65,101,119,145],"energy":[11,105,147],"were":[13,74],"studied":[14,75],"in":[15,33,69,76,86,92],"normal":[16,70,150],"mice":[17],"by":[18],"measuring":[19],"contents":[20,88,103],"several":[22],"major":[23],"metabolites":[24],"(creatine-P,":[25],"adenosine":[26],"triphosphate,":[27],"glucose,":[28],"glycogen,":[29],"lactate":[30,93],"pyruvate)":[32],"the":[34,42],"brain":[35,72],"30":[36],"min":[37],"after":[38],"intraperitoneal":[39],"administration":[40],"drug":[43],"at":[44,125],"doses":[45],"1,":[47],"4":[48],"16":[50],"mg/kg":[51],"compared":[53],"with":[54],"those":[55],"dihydroergotoxine":[57],"(DHE).":[58],"In":[59,108],"addition,":[60],"influences":[61],"both":[63],"drugs":[64],"cytochrome":[66,121],"oxidase":[67,122],"activity":[68],"mouse":[71],"homogenate":[73],"vitro.":[77],"Both":[78],"nicergoline":[80,113,137],"DHE":[82,124],"caused":[83],"12-20%":[84],"increases":[85],"creatine-P":[87],"10-37%":[90],"decreases":[91],"pyruvate":[95],"contents,":[96],"but":[97],"had":[98,114],"no":[99],"effect":[100],"glucose":[102],"reserve":[106],"values.":[107],"vitro":[109],"studies":[110],"revealed":[111],"that":[112,136],"more":[115],"potent":[116],"activating":[117],"action":[118],"than":[123],"final":[126],"concentrations":[127],"10":[129],"100":[131],"\u03bcM.":[132],"These":[133],"results":[134],"suggest":[135],"has":[138],"promoting":[140],"action,":[141],"similar":[142],"to":[143],"DHE,":[144],"mouse.":[151]},"counts_by_year":[{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
