{"id":"https://openalex.org/W2416185151","doi":null,"title":"Immunohistochemical analysis of the retrobulbar tissues in Graves' ophthalmopathy.","display_name":"Immunohistochemical analysis of the retrobulbar tissues in Graves' ophthalmopathy.","publication_year":1989,"publication_date":"1989-02-01","ids":{"openalex":"https://openalex.org/W2416185151","mag":"2416185151","pmid":"https://pubmed.ncbi.nlm.nih.gov/2784734","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1542121"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1542121","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1542121","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1542121","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109158868","display_name":"Anthony P. Weetman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A P Weetman","raw_affiliation_strings":["Department of Medicine, University of Cambridge Clinical School, UK","Dept of Medicine, University of Cambridge Clinical School, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Cambridge Clinical School, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Dept of Medicine, University of Cambridge Clinical School, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032034922","display_name":"Shara B. Cohen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Cohen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109250440","display_name":"K C Gatter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K C Gatter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090857884","display_name":"P Fells","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Fells","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040351145","display_name":"Brian S. F. Shine","orcid":"https://orcid.org/0000-0002-1016-8638","observed_orcids":["https://orcid.org/0000-0002-1016-8638"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Shine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.67,"has_fulltext":false,"cited_by_count":188,"citation_normalized_percentile":{"value":0.9918936,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"75","issue":"2","first_page":"222","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graves-ophthalmopathy","display_name":"Graves' ophthalmopathy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/graves-disease","display_name":"Graves' disease","score":0.9710000157356262},{"id":"https://openalex.org/keywords/extraocular-muscles","display_name":"extraocular muscles","score":0.8859999775886536},{"id":"https://openalex.org/keywords/mononuclear-cell-infiltrate","display_name":"mononuclear cell infiltrate","score":0.9350000023841858},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cd3","display_name":"CD3","score":0.8389999866485596},{"id":"https://openalex.org/keywords/uchl1","display_name":"UCHL1","score":0.984000027179718},{"id":"https://openalex.org/keywords/cd45r","display_name":"CD45R","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ia-antigens","display_name":"Ia antigens","score":0.9259999990463257},{"id":"https://openalex.org/keywords/lymphoid-follicles","display_name":"lymphoid follicles","score":0.7039999961853027},{"id":"https://openalex.org/keywords/orbital-fat","display_name":"orbital fat","score":0.5559999942779541},{"id":"https://openalex.org/keywords/connective-tissue","display_name":"connective tissue","score":0.8100000023841858},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.723980188369751},{"id":"https://openalex.org/C2776807875","wikidata":"https://www.wikidata.org/wiki/Q533979","display_name":"Extraocular muscles","level":2,"score":0.6941866278648376},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.6228870749473572},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5746150612831116},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.539351224899292},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5360192656517029},{"id":"https://openalex.org/C2781294515","wikidata":"https://www.wikidata.org/wiki/Q2733470","display_name":"Stain","level":3,"score":0.5142309069633484},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.4994649887084961},{"id":"https://openalex.org/C2777534427","wikidata":"https://www.wikidata.org/wiki/Q6057165","display_name":"Interstitial cell","level":2,"score":0.49832773208618164},{"id":"https://openalex.org/C167464567","wikidata":"https://www.wikidata.org/wiki/Q1775422","display_name":"Mononuclear cell infiltration","level":2,"score":0.4746675491333008},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4645746648311615},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4455231726169586},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4359334111213684},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.4307257831096649},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.41503891348838806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3238945007324219},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29616042971611023},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.22514215111732483},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.21872395277023315},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009801","descriptor_name":"Oculomotor Muscles","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009915","descriptor_name":"Orbit","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009916","descriptor_name":"Orbital Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1542121","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1542121","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:2784734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2784734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"mag:2416185151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2784734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1542121","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1542121","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W262999132","https://openalex.org/W1513433026","https://openalex.org/W1664338959","https://openalex.org/W1965113827","https://openalex.org/W1969178843","https://openalex.org/W1985801069","https://openalex.org/W1986612162","https://openalex.org/W2005777179","https://openalex.org/W2056191911","https://openalex.org/W2060630385","https://openalex.org/W2066547218","https://openalex.org/W2074382692","https://openalex.org/W2080789379","https://openalex.org/W2092987812","https://openalex.org/W2124314287","https://openalex.org/W2138954731","https://openalex.org/W2332910275","https://openalex.org/W2424130865"],"related_works":["https://openalex.org/W2083555335","https://openalex.org/W2116562190","https://openalex.org/W1995801427","https://openalex.org/W1978740806","https://openalex.org/W2056301742","https://openalex.org/W2056222602","https://openalex.org/W35989591","https://openalex.org/W2112765640","https://openalex.org/W7098772792","https://openalex.org/W1986414266"],"abstract_inverted_index":{"We":[0],"have":[1],"characterized":[2],"the":[3,8,56,124,132,138,165,168],"mononuclear":[4],"cell":[5],"infiltrate":[6],"in":[7,30,88,135],"extraocular":[9,169],"muscle":[10,116,170],"of":[11,22,27,38,137,179],"three":[12],"patients":[13,105],"with":[14,44,52,143,153],"Graves'":[15,149],"disease,":[16],"using":[17],"antibodies":[18],"which":[19,39,70,111],"permit":[20],"staining":[21],"paraffin-embedded":[23],"tissue.":[24],"The":[25,95],"majority":[26],"lymphocytes,":[28],"occurring":[29],"foci":[31],"or":[32,43],"interstitially,":[33],"were":[34,77,81,93,112,129],"T":[35,46,154],"cells,":[36,172],"most":[37],"stain":[40],"for":[41],"CD3":[42],"UCHL1.":[45],"cells":[47,72,76,110,117,126],"few,":[48],"if":[49],"any,":[50],"stained":[51,142],"SN130,":[53],"directed":[54],"against":[55,164],"CD45R":[57],"determinant.":[58],"This":[59],"suggests":[60],"that":[61,148],"these":[62],"lymphocytes":[63],"comprise":[64],"a":[65,102,158],"recently":[66],"activated":[67],"population":[68],"within":[69],"memory":[71],"may":[73,176],"reside.":[74],"B":[75,161],"also":[78,141],"found":[79],"but":[80,123],"predominantly":[82],"confined":[83],"to":[84,157],"focal":[85],"aggregates,":[86],"and":[87,98,131,156],"one":[89],"patient":[90],"lymphoid":[91],"follicles":[92],"seen.":[94],"orbital":[96],"fat":[97],"connective":[99],"tissue":[100],"from":[101,182],"further":[103],"two":[104],"contained":[106],"very":[107],"few":[108],"infiltrating":[109],"mainly":[113],"UCHL1-positive.":[114],"Eye":[115],"did":[118],"not":[119],"express":[120],"Ia":[121],"antigens":[122],"interstitial":[125,171],"between":[127],"them":[128],"Ia-positive":[130],"vascular":[133],"endothelium":[134],"four":[136],"five":[139],"specimens":[140],"Ia.":[144],"These":[145],"results":[146],"indicate":[147],"ophthalmopathy":[150],"is":[151],"associated":[152],"cell,":[155,162],"lesser":[159],"extent":[160],"responses":[163],"retrobulbar":[166],"tissues;":[167],"probably":[173],"including":[174],"fibroblasts,":[175],"be":[177],"targets":[178],"activation":[180],"resulting":[181],"this":[183],"infiltration.":[184]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}