{"id":"https://openalex.org/W2416010263","doi":null,"title":"HIV-1 Env-chemokine receptor interactions in primary human macrophages: entry and beyond.","display_name":"HIV-1 Env-chemokine receptor interactions in primary human macrophages: entry and beyond.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2416010263","mag":"2416010263","pmid":"https://pubmed.ncbi.nlm.nih.gov/12845769"},"language":"en","primary_location":{"id":"pmid:12845769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12845769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research initiative, treatment action : RITA","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074582058","display_name":"Ronald G. Collman","orcid":"https://orcid.org/0000-0002-0508-3701","observed_orcids":["https://orcid.org/0000-0002-0508-3701"]},"institutions":[{"id":"https://openalex.org/I4210127693","display_name":"Penn Center for AIDS Research","ror":"https://ror.org/047939x15","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052","https://openalex.org/I1335321130","https://openalex.org/I4210127693","https://openalex.org/I79576946"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ronald G Collman","raw_affiliation_strings":["University of Pennsylvania School of Medicine and Penn Center for AIDS Research, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania School of Medicine and Penn Center for AIDS Research, USA","institution_ids":["https://openalex.org/I4210127693","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074582058"],"corresponding_institution_ids":["https://openalex.org/I4210127693","https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.299,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.61598861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"2","first_page":"6","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.6650000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.6650000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.329800009727478,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gp120","display_name":"gp120","score":0.8690000176429749},{"id":"https://openalex.org/keywords/chemokine-receptors","display_name":"chemokine receptors","score":0.890999972820282},{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":1.0},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9660000205039978},{"id":"https://openalex.org/keywords/receptor-signaling","display_name":"receptor signaling","score":0.8299999833106995},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.8930000066757202},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.765999972820282},{"id":"https://openalex.org/keywords/chemokine-secretion","display_name":"chemokine secretion","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hiv-encephalopathy","display_name":"HIV encephalopathy","score":0.8899999856948853},{"id":"https://openalex.org/keywords/lymphocytic-interstitial-pneumonia","display_name":"lymphocytic interstitial pneumonia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hiv-pathogenesis","display_name":"HIV pathogenesis","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C129013479","wikidata":"https://www.wikidata.org/wiki/Q21111916","display_name":"CCR1","level":5,"score":0.7460204362869263},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.7282944917678833},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6247550845146179},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5738073587417603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.572722315788269},{"id":"https://openalex.org/C45635710","wikidata":"https://www.wikidata.org/wiki/Q418404","display_name":"Chemokine receptor CCR5","level":5,"score":0.5507081151008606},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5064378976821899},{"id":"https://openalex.org/C186382791","wikidata":"https://www.wikidata.org/wiki/Q3648585","display_name":"CCL21","level":5,"score":0.4688205420970917},{"id":"https://openalex.org/C1423137","wikidata":"https://www.wikidata.org/wiki/Q21113928","display_name":"CCR3","level":5,"score":0.4383780360221863},{"id":"https://openalex.org/C94205230","wikidata":"https://www.wikidata.org/wiki/Q5005868","display_name":"C-C chemokine receptor type 6","level":5,"score":0.4240509271621704},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4182373881340027},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3847416937351227},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2725754380226135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12228509783744812}],"mesh":[{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015686","descriptor_name":"Gene Products, env","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12845769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12845769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research initiative, treatment action : RITA","raw_type":"Journal Article"},{"id":"mag:2416010263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12845769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2027809408","https://openalex.org/W1981258449","https://openalex.org/W2116384200","https://openalex.org/W7100110826","https://openalex.org/W2157245965","https://openalex.org/W2027433436","https://openalex.org/W1917182292","https://openalex.org/W2099141302","https://openalex.org/W7100603363","https://openalex.org/W2165528500"],"abstract_inverted_index":{"While":[0],"HIV":[1,103,160,180],"has":[2,161],"subverted":[3],"the":[4,132,141,173,189],"chemokine":[5,133,145],"receptors":[6,47,134,146],"CCR5":[7],"and":[8,52,75,88,101,120,124,152,182,194],"CXCR4":[9,74],"for":[10,157],"its":[11],"own":[12],"use":[13],"as":[14,116,179],"an":[15],"entry":[16],"co-receptor,":[17],"their":[18],"normal":[19],"functions":[20],"are":[21,135,147,188],"to":[22,27,58,131],"transduce":[23],"signals":[24,44,70],"in":[25,34,48,71,113,149,172],"response":[26],"extracellular":[28],"ligands.":[29],"Our":[30,60],"lab":[31],"is":[32,95],"interested":[33],"understanding":[35],"how":[36,53],"HIV-1":[37,63],"glycoprotein":[38],"120":[39],"(gp120)":[40],"may":[41,56,168],"activate":[42],"intracellular":[43],"through":[45,73,143],"these":[46,54],"primary":[49,150],"human":[50],"macrophages,":[51,114,151],"responses":[55,112,167],"contribute":[57],"pathogenesis.":[59],"studies":[61,138],"demonstrate":[62,126],"gp120":[64,100,106],"elicits":[65,107],"several":[66],"different":[67],"types":[68],"of":[69,90,110,118,175],"macrophages":[72,187],"CCR5,":[76],"including":[77],"calcium":[78],"elevations,":[79],"ionic":[80],"channel":[81],"activation,":[82,87],"non-receptor":[83],"protein":[84],"tyrosine":[85],"kinase":[86],"activation":[89,94,197],"MAP":[91],"kinases.":[92],"Receptor":[93],"triggered":[96],"by":[97],"both":[98],"monomeric":[99],"whole":[102],"virus.":[104],"Furthermore,":[105],"a":[108,154,170,199],"number":[109],"functional":[111],"such":[115,178],"secretion":[117],"chemokines":[119],"other":[121],"soluble":[122],"products,":[123],"we":[125],"that":[127,159],"specific":[128],"pathways":[129,142],"linked":[130],"responsible.":[136],"These":[137,165],"help":[139],"illuminate":[140],"which":[144],"coupled":[148],"provide":[153],"mechanistic":[155],"basis":[156],"effects":[158],"on":[162],"macrophage":[163],"function.":[164],"signaling":[166],"play":[169],"role":[171],"pathogenesis":[174],"organ":[176],"dysfunction":[177],"encephalopathy":[181],"lymphocytic":[183],"interstitial":[184],"pneumonitis":[185],"where":[186],"principal":[190],"infected":[191],"cell":[192],"type":[193],"inappropriate":[195],"immune":[196],"plays":[198],"central":[200],"role.":[201]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
