{"id":"https://openalex.org/W2415972740","doi":null,"title":"Carbachol stimulates inositol phosphate formation transiently in Trypanosoma cruzi.","display_name":"Carbachol stimulates inositol phosphate formation transiently in Trypanosoma cruzi.","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W2415972740","mag":"2415972740","pmid":"https://pubmed.ncbi.nlm.nih.gov/8696258"},"language":"en","primary_location":{"id":"pmid:8696258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8696258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular biology (Noisy-le-Grand, France)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112077125","display_name":"M\ufffdnicaN. Garrido","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15366983","display_name":"Universidad Nacional de R\u00edo Cuarto","ror":"https://ror.org/0002pcv65","country_code":"AR","type":"education","lineage":["https://openalex.org/I15366983"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"M N Garrido","raw_affiliation_strings":["Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas, F\u00edsico-Qu\u00edmicas y Naturales, Universidad Nacional de R\u00edo Cuarto, C\u00f3rdoba, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas, F\u00edsico-Qu\u00edmicas y Naturales, Universidad Nacional de R\u00edo Cuarto, C\u00f3rdoba, Argentina","institution_ids":["https://openalex.org/I15366983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110405767","display_name":"Bollo Mi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M I Bollo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110405768","display_name":"Machado-Domenech Ee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E E Machado-Domenech","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5422,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.68700737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"2","first_page":"221","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbachol","display_name":"carbachol","score":0.9800000190734863},{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":0.996999979019165},{"id":"https://openalex.org/keywords/epimastigotes","display_name":"epimastigotes","score":0.9179999828338623},{"id":"https://openalex.org/keywords/inositol-phosphates","display_name":"inositol phosphates","score":0.8410000205039978},{"id":"https://openalex.org/keywords/inositol-trisphosphate","display_name":"inositol trisphosphate","score":0.9599999785423279},{"id":"https://openalex.org/keywords/inositol-tetrakisphosphate","display_name":"inositol tetrakisphosphate","score":0.9430000185966492},{"id":"https://openalex.org/keywords/phosphoinositide-metabolism","display_name":"phosphoinositide metabolism","score":0.9860000014305115},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.9269999861717224},{"id":"https://openalex.org/keywords/g-proteins","display_name":"G proteins","score":0.7379999756813049},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.6380000114440918},{"id":"https://openalex.org/keywords/cholinergic-stimulation","display_name":"cholinergic stimulation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/second-messengers","display_name":"second messengers","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2778988552","wikidata":"https://www.wikidata.org/wiki/Q419401","display_name":"Carbachol","level":3,"score":0.9706627726554871},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.898787260055542},{"id":"https://openalex.org/C2778618036","wikidata":"https://www.wikidata.org/wiki/Q2878809","display_name":"Inositol phosphate","level":4,"score":0.8460484743118286},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.7100551128387451},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.6503336429595947},{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.608123242855072},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4847261905670166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46853604912757874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45326846837997437},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.442141056060791},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.4270821213722229},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42072439193725586},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3900303840637207},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35800665616989136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09071597456932068},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001285","descriptor_name":"Atropine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002217","descriptor_name":"Carbachol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007294","descriptor_name":"Inositol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8696258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8696258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular biology (Noisy-le-Grand, France)","raw_type":"Journal Article"},{"id":"mag:2415972740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8696258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2032695231","https://openalex.org/W2122205921","https://openalex.org/W2077315626","https://openalex.org/W217723520","https://openalex.org/W1987484874","https://openalex.org/W2321217079","https://openalex.org/W1508438740","https://openalex.org/W3150062084","https://openalex.org/W1972522826","https://openalex.org/W225588386"],"abstract_inverted_index":{"The":[0,29,85],"effect":[1,80],"of":[2,12,27,31,37,46,54,58,107],"carbachol":[3,38,77,89],"on":[4],"Trypanosoma":[5],"cruzi":[6],"epimastigote":[7,13],"forms":[8],"was":[9,49,81],"studied.":[10],"Suspension":[11],"cells":[14],"prelabelled":[15],"with":[16,69,104],"myo[3H]-inositol":[17],"were":[18,39,62],"incubated":[19],"at":[20,72],"28":[21],"degrees":[22],"C":[23,126],"in":[24,93],"the":[25,35,44,52,56,66,76,105],"presence":[26,53],"carbachol.":[28],"levels":[30,57],"inositol":[32,47],"phosphate":[33,48],"after":[34,75],"challenge":[36],"determined":[40],"to":[41,124],"see":[42],"if":[43],"accumulation":[45],"time-dependent.":[50],"In":[51,109],"Li+":[55],"IP3":[59,116],"and":[60,96],"IP4":[61],"significantly":[63],"increased":[64],"during":[65],"3":[67],"min.":[68,74],"a":[70,120,128],"peak":[71],"1":[73],"challenge.":[78],"This":[79],"suppressed":[82],"by":[83,127],"atropine.":[84],"results":[86],"show":[87],"that":[88,114],"influences":[90],"rapid":[91],"changes":[92],"phosphoinositide":[94],"metabolism":[95],"they":[97,111],"are":[98],"time-dependent":[99],"involving":[100],"second-messenger":[101],"systems":[102],"associated":[103],"generation":[106,117],"IP3.":[108],"addition":[110],"would":[112],"suggest":[113],"this":[115],"is":[118],"through":[119],"receptor-mediated":[121],"process":[122],"linked":[123],"phospholipase":[125],"G-protein.":[129]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}