{"id":"https://openalex.org/W2415917258","doi":null,"title":"Improvement of secondary hyperparathyroidism and reduction of the set point of calcium after intravenous calcitriol.","display_name":"Improvement of secondary hyperparathyroidism and reduction of the set point of calcium after intravenous calcitriol.","publication_year":1993,"publication_date":"1993-06-01","ids":{"openalex":"https://openalex.org/W2415917258","mag":"2415917258","pmid":"https://pubmed.ncbi.nlm.nih.gov/8320905"},"language":"en","primary_location":{"id":"pmid:8320905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8320905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international. Supplement","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111870113","display_name":"F. Malberti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150517","display_name":"Ospedale Maggiore di Lodi","ror":"https://ror.org/04jn5sa20","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150517"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Malberti","raw_affiliation_strings":["Servizio Dialisi, Ospedale Maggiore, Lodi, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servizio Dialisi, Ospedale Maggiore, Lodi, Italy","institution_ids":["https://openalex.org/I4210150517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049927293","display_name":"Maurizio Surian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Surian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024444074","display_name":"Pablo Cosci","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Cosci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2205,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.88240793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"41","issue":null,"first_page":"S125","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secondary-hyperparathyroidism","display_name":"secondary hyperparathyroidism","score":0.9810000061988831},{"id":"https://openalex.org/keywords/intravenous-calcitriol","display_name":"intravenous calcitriol","score":0.9599999785423279},{"id":"https://openalex.org/keywords/osteitis-fibrosa","display_name":"osteitis fibrosa","score":0.7689999938011169},{"id":"https://openalex.org/keywords/calcium-set-point","display_name":"calcium set point","score":0.7049999833106995},{"id":"https://openalex.org/keywords/ionized-calcium","display_name":"ionized calcium","score":0.7139999866485596},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/hemodiafiltration","display_name":"hemodiafiltration","score":0.906000018119812},{"id":"https://openalex.org/keywords/dialysate-calcium","display_name":"dialysate calcium","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hypercalcemia","display_name":"hypercalcemia","score":0.9449999928474426},{"id":"https://openalex.org/keywords/phosphate","display_name":"phosphate","score":0.515999972820282},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.8849999904632568},{"id":"https://openalex.org/keywords/parathyroid-function","display_name":"parathyroid function","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2776079296","wikidata":"https://www.wikidata.org/wiki/Q139195","display_name":"Calcitriol","level":3,"score":0.9107916355133057},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7323499917984009},{"id":"https://openalex.org/C2778838027","wikidata":"https://www.wikidata.org/wiki/Q3622611","display_name":"Secondary hyperparathyroidism","level":4,"score":0.732295572757721},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7157566547393799},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.7100062370300293},{"id":"https://openalex.org/C2775945674","wikidata":"https://www.wikidata.org/wiki/Q1344835","display_name":"Hyperparathyroidism","level":2,"score":0.6279476284980774},{"id":"https://openalex.org/C176674119","wikidata":"https://www.wikidata.org/wiki/Q11582","display_name":"Liter","level":2,"score":0.5757315158843994},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.5616994500160217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.547756552696228},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.5469690561294556},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.4472910165786743},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.4181874990463257},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3901519775390625},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.2713995575904846},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06728014349937439},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006962","descriptor_name":"Hyperparathyroidism, Secondary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006962","descriptor_name":"Hyperparathyroidism, Secondary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8320905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8320905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international. Supplement","raw_type":"Journal Article"},{"id":"mag:2415917258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8320905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2106115098","https://openalex.org/W1895667848","https://openalex.org/W1990254836","https://openalex.org/W2038133666","https://openalex.org/W2031888876","https://openalex.org/W2402346295","https://openalex.org/W153690400","https://openalex.org/W2463832726","https://openalex.org/W1993474595","https://openalex.org/W849497366"],"abstract_inverted_index":{"In":[0],"this":[1],"study":[2],"we":[3],"evaluated":[4],"the":[5,145,148,154,190,220,227,249,255],"effect":[6],"of":[7,42,141,152,166,182,193,206,212,251,258],"intravenous":[8,43,218],"calcitriol":[9,76,219],"on":[10,169,185],"parathyroid":[11],"function":[12],"and":[13,21,118,171,229,234,241,254],"ionized":[14,46,149,221],"calcium/PTH":[15,222],"sigmoidal":[16,223],"curve":[17,224],"obtained":[18,238],"during":[19,239],"low":[20,240],"high":[22,242],"calcium":[23,47,156,243],"hemodialysis":[24,170],"in":[25,147,164,180],"10":[26],"patients":[27,168,184],"with":[28],"osteitis":[29],"fibrosa":[30],"whose":[31],"secondary":[32],"hyperparathyroidism":[33],"was":[34,157,195,203],"refractory":[35],"to":[36,53,67,81,97,110,126,136,144,161,208,226],"conventional":[37],"therapy.":[38],"After":[39,217],"four":[40,181],"months":[41],"calcitriol,":[44],"serum":[45,61,75],"increased":[48],"from":[49,63,77,93,106,122,159],"1.28":[50],"+/-":[51,55,65,69,79,83,95,99,108,112,124,128,197,214],"0.08":[52],"1.37":[54],"0.11":[56],"mmol/liter":[57,71,163],"(P":[58,72,86,102,115,130],"<":[59,87,103,116,131],"0.001),":[60,88],"phosphate":[62],"1.54":[64],"0.18":[66],"1.79":[68],"0.4":[70],"=":[73],"NS),":[74],"16.7":[78],"9.9":[80],"34.3":[82],"6.4":[84],"pg/ml":[85],"while":[89],"alkaline":[90],"phosphatase":[91],"decreased":[92,158,204,246],"366":[94],"340":[96],"226":[98],"180":[100],"IU/liter":[101],"0.05),":[104],"osteocalcin":[105],"46.4":[107],"20":[109],"34.5":[111],"15.3":[113],"ng/ml":[114],"0.05)":[117],"basal":[119,252],"intact":[120],"PTH":[121,134,233,237],"1069":[123],"700":[125],"305":[127],"270":[129],"0.01).":[132],"Basal":[133],"started":[135],"decrease":[137],"after":[138],"one":[139],"month":[140,192],"treatment":[142],"prior":[143],"increase":[146],"calcium.":[150],"Because":[151],"hypercalcemia,":[153],"dialysate":[155],"1.75":[160],"1.5":[162],"three":[165],"five":[167,183],"calcium-containing":[172],"solutions":[173],"were":[174],"substituted":[175],"by":[176],"calcium-free":[177],"replacement":[178],"fluids":[179],"hemodiafiltration.":[186],"Calcitriol":[187],"dose":[188,211],"at":[189],"first":[191],"therapy":[194],"5.6":[196],"0.8":[198],"micrograms/week,":[199],"but":[200],"successively":[201],"it":[202],"because":[205],"hypercalcemia":[207],"a":[209],"final":[210],"3.6":[213],"1.3":[215],"micrograms/week.":[216],"shifted":[225],"left":[228],"downward.":[230],"Maximally":[231],"stimulated":[232],"maximally":[235],"inhibited":[236],"dialysis":[244],"significantly":[245],"as":[247],"did":[248],"ratio":[250],"PTH/PTHmax":[253],"set":[256],"point":[257],"calcium.(ABSTRACT":[259],"TRUNCATED":[260],"AT":[261],"250":[262],"WORDS)":[263]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
