{"id":"https://openalex.org/W2415859080","doi":null,"title":"Cell heterogeneity in sickle cell disease: quantitation of the erythrocyte density profile.","display_name":"Cell heterogeneity in sickle cell disease: quantitation of the erythrocyte density profile.","publication_year":1985,"publication_date":"1985-07-01","ids":{"openalex":"https://openalex.org/W2415859080","mag":"2415859080","pmid":"https://pubmed.ncbi.nlm.nih.gov/4009021"},"language":"en","primary_location":{"id":"pmid:4009021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4009021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112805059","display_name":"Griffin P. Rodgers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G P Rodgers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047048178","display_name":"Alan N. Schechter","orcid":"https://orcid.org/0000-0002-6055-6452","observed_orcids":["https://orcid.org/0000-0002-6055-6452","https://orcid.org/0000-0002-5235-9408"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A N Schechter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039623171","display_name":"Noguchi Ct","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C T Noguchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.2315,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.96360559,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"106","issue":"1","first_page":"30","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9679999947547913},{"id":"https://openalex.org/keywords/erythrocyte-heterogeneity","display_name":"erythrocyte heterogeneity","score":0.8820000290870667},{"id":"https://openalex.org/keywords/discontinuous-density-gradient","display_name":"discontinuous density gradient","score":0.6169999837875366},{"id":"https://openalex.org/keywords/vessel-occlusion","display_name":"vascular occlusion","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.752444326877594},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.6994494795799255},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.649423360824585},{"id":"https://openalex.org/C2775897519","wikidata":"https://www.wikidata.org/wiki/Q1273048","display_name":"Mean corpuscular hemoglobin concentration","level":4,"score":0.6266223192214966},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6017857789993286},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.5347093343734741},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.501213788986206},{"id":"https://openalex.org/C2779668550","wikidata":"https://www.wikidata.org/wiki/Q1642147","display_name":"Hemoglobinopathy","level":3,"score":0.47022438049316406},{"id":"https://openalex.org/C78529466","wikidata":"https://www.wikidata.org/wiki/Q1363819","display_name":"Red blood cell distribution width","level":2,"score":0.45381399989128113},{"id":"https://openalex.org/C2780591564","wikidata":"https://www.wikidata.org/wiki/Q409030","display_name":"Hemoglobin C","level":3,"score":0.44133275747299194},{"id":"https://openalex.org/C2780554921","wikidata":"https://www.wikidata.org/wiki/Q1940759","display_name":"Mean corpuscular hemoglobin","level":4,"score":0.43979644775390625},{"id":"https://openalex.org/C2777208419","wikidata":"https://www.wikidata.org/wiki/Q4347672","display_name":"Red Cell","level":2,"score":0.41521281003952026},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40005218982696533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3665104806423187},{"id":"https://openalex.org/C2776175824","wikidata":"https://www.wikidata.org/wiki/Q1145668","display_name":"Hemolytic anemia","level":2,"score":0.36589890718460083},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35122090578079224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2907373607158661},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27459219098091125},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2632579803466797},{"id":"https://openalex.org/C2781058662","wikidata":"https://www.wikidata.org/wiki/Q1358504","display_name":"Mean corpuscular volume","level":3,"score":0.2543770968914032}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003993","descriptor_name":"Dibutyl Phthalate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004906","descriptor_name":"Erythrocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010795","descriptor_name":"Phthalic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4009021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4009021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:2415859080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4009021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2416456695","https://openalex.org/W2015250820","https://openalex.org/W2410115737","https://openalex.org/W2075201352","https://openalex.org/W2414897635","https://openalex.org/W1862130558","https://openalex.org/W2122581354","https://openalex.org/W2039154900","https://openalex.org/W2337836335","https://openalex.org/W2022368107"],"abstract_inverted_index":{"An":[0],"increasing":[1],"body":[2],"of":[3,17,30,58,61,83,108,121,145,204],"experimental":[4],"evidence":[5],"demonstrates":[6],"that":[7,70,148],"intracellular":[8,31,180],"hemoglobin":[9,32,65,85,181],"concentration":[10,66,86],"and":[11,92,125,184,201],"composition":[12],"is":[13],"a":[14,35,79],"primary":[15],"determinant":[16],"pathophysiology":[18],"in":[19,34,111,142,168,185,188],"sickle":[20,75,114,133,206],"cell":[21,76,99,109,115,134,146,169,199,207],"disease.":[22],"To":[23],"quantitate":[24],"more":[25],"precisely":[26],"the":[27,44,97,122,143,195,205],"heterogeneous":[28],"distribution":[29,82,144],"concentrations":[33],"given":[36],"individual":[37],"with":[38,74,113,131],"this":[39],"disease,":[40],"we":[41],"have":[42],"calibrated":[43],"phthalate":[45,158],"ester":[46,159],"separation":[47],"technique":[48],"by":[49],"using":[50],"discontinuous":[51],"Stractan":[52],"density":[53,100,155],"gradients":[54],"to":[55,138,165,174,193],"isolate":[56],"subpopulations":[57],"red":[59,98,198],"cells":[60],"relatively":[62],"uniform":[63],"corpuscular":[64,84],"values.":[67,156],"We":[68],"find":[69],"blood":[71],"from":[72,102],"individuals":[73],"anemia":[77,116],"exhibits":[78],"markedly":[80],"broader":[81],"values,":[87],"containing":[88],"both":[89],"very":[90,93,123,126],"light":[91,124],"dense":[94,127],"cells,":[95],"than":[96],"profile":[101],"normal":[103],"individuals.":[104],"This":[105],"increased":[106],"breadth":[107],"densities":[110,147,170],"patients":[112,130],"remains":[117],"even":[118],"after":[119],"exclusion":[120],"subpopulations.":[128],"In":[129],"stable":[132],"anemia,":[135],"there":[136],"appears":[137],"be":[139,163],"minimal":[140],"variation":[141],"are":[149],"unimodal":[150],"but":[151],"skewed":[152],"toward":[153],"higher":[154],"The":[157],"method":[160],"can":[161],"conveniently":[162],"used":[164],"follow":[166],"changes":[167],"during":[171],"vaso-occlusive":[172],"events,":[173],"monitor":[175],"therapy":[176],"targeted":[177],"at":[178],"modifying":[179],"S":[182],"concentrations,":[183],"sequential":[186],"applications":[187],"large":[189],"field":[190],"trials":[191],"designed":[192],"determine":[194],"relationship":[196],"between":[197],"heterogeneity":[200],"specific":[202],"manifestations":[203],"syndromes.":[208]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}