{"id":"https://openalex.org/W2415809796","doi":null,"title":"Effects of changes in circulating volume and in arterial pressure on plasma renin activity in the intact rat.","display_name":"Effects of changes in circulating volume and in arterial pressure on plasma renin activity in the intact rat.","publication_year":1985,"publication_date":"1985-03-01","ids":{"openalex":"https://openalex.org/W2415809796","mag":"2415809796","pmid":"https://pubmed.ncbi.nlm.nih.gov/3890041"},"language":"en","primary_location":{"id":"pmid:3890041","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3890041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista espanola de fisiologia","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054556979","display_name":"Albert Soler","orcid":"https://orcid.org/0000-0003-3140-182X","observed_orcids":["https://orcid.org/0000-0003-3140-182X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Soler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041501641","display_name":"C Garcia del Rio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Garc\u00eda del R\u00edo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054771214","display_name":"L Garc\u00eda-Torres","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Garc\u00eda-Torres","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052771895","display_name":"F Vargas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Vargas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023304080","display_name":"Antonio Mart\u00edn Andr\u00e9s","orcid":"https://orcid.org/0000-0002-2548-2638","observed_orcids":["https://orcid.org/0000-0002-2548-2638"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Mart\u00edn-Andr\u00e9s","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103028244","display_name":"C Osorio","orcid":"https://orcid.org/0009-0007-5949-5748","observed_orcids":["https://orcid.org/0009-0007-5949-5748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Osorio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3666263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"1","first_page":"107","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/arterial-pressure","display_name":"arterial pressure","score":0.9409999847412109},{"id":"https://openalex.org/keywords/hypovolemia","display_name":"hypovolemia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.5070000290870667},{"id":"https://openalex.org/keywords/plasma-protein-levels","display_name":"plasma protein levels","score":0.875},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.9800000190734863},{"id":"https://openalex.org/keywords/plasma-volume-reduction","display_name":"plasma volume reduction","score":0.7300000190734863},{"id":"https://openalex.org/keywords/controlled-hemorrhage","display_name":"controlled hemorrhage","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.7730000019073486},{"id":"https://openalex.org/keywords/renin-secretion","display_name":"renin secretion","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.7929092049598694},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.6891108751296997},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.6804922223091125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6589305400848389},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.6005651950836182},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5813701748847961},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.5667775869369507},{"id":"https://openalex.org/C2991747820","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Plasma volume","level":2,"score":0.5535550117492676},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5278679728507996},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5173265933990479},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.5143893361091614},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44870251417160034},{"id":"https://openalex.org/C195646399","wikidata":"https://www.wikidata.org/wiki/Q6058580","display_name":"Intravascular volume status","level":3,"score":0.4401237964630127},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2648109495639801},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.11540448665618896},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001810","descriptor_name":"Blood Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006982","descriptor_name":"Hypertonic Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011311","descriptor_name":"Pressoreceptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012769","descriptor_name":"Shock","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012769","descriptor_name":"Shock","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3890041","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3890041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista espanola de fisiologia","raw_type":"Journal Article"},{"id":"mag:2415809796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3890041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2079335733","https://openalex.org/W2142302960","https://openalex.org/W1987417467","https://openalex.org/W2470617591","https://openalex.org/W2253517881","https://openalex.org/W2146197019","https://openalex.org/W2410310440","https://openalex.org/W2004210913","https://openalex.org/W2039200331","https://openalex.org/W2378170445"],"abstract_inverted_index":{"The":[0,129],"effects":[1],"of":[2,34,42,101,118,125],"changes":[3,44,108,139,152],"in":[4,8,16,40,45,53,109,131,140,153,162],"arterial":[5],"pressure":[6,186],"and":[7,66,122,165],"circulating":[9,111,141],"volume":[10,27,105,112,177],"on":[11,104,150],"Plasma":[12,62,81],"Renin":[13],"Activity":[14],"(PRA)":[15],"the":[17,54,58,76,80,110,138,151,163,172,175,184],"intact":[18,164],"rat":[19],"were":[20,73,113],"compared":[21,74],"by":[22,31,57,115],"two":[23],"experimental":[24],"procedures.":[25],"Gradual":[26],"depletion":[28],"was":[29,51],"induced":[30,114],"intraperitoneal":[32],"injection":[33,72],"a":[35,87,98,134],"hyperoncotic":[36],"polyethyleneglycol":[37],"solution":[38],"(PEG)":[39],"absence":[41],"acute":[43],"Systolic":[46],"Arterial":[47,155],"Pressure":[48,156],"(SAP).":[49],"SAP":[50],"measured":[52],"conscious":[55,166],"state":[56],"tail":[59],"cuff":[60],"technique.":[61],"Protein":[63],"Concentration":[64],"(PPC)":[65],"Hematocrit":[67],"(Hct)":[68],"increases":[69],"after":[70],"PEG":[71],"as":[75],"index":[77],"for":[78],"measuring":[79],"Volume":[82],"Reduction":[83],"(PVR).":[84],"PRA":[85,132],"showed":[86,133],"significant":[88,135],"(p":[89],"less":[90],"than":[91,180],"0.001)":[92],"linear":[93],"relationship":[94,136],"with":[95,137],"PPC,":[96],"suggesting":[97],"direct":[99],"dependence":[100,149],"renin":[102,168],"secretion":[103,169],"depletion.":[106],"Acute":[107],"controlled":[116],"hemorrhages":[117],"5.0,":[119],"10.0,":[120],"15.0":[121],"20.0":[123],"ml":[124],"blood/kg":[126],"body":[127],"weight.":[128],"increase":[130],"volume,":[142],"but":[143],"it":[144],"did":[145],"not":[146],"show":[147],"any":[148],"Mean":[154],"(MAP).":[157],"Our":[158],"results":[159],"suggest":[160],"that,":[161],"rat,":[167],"responds":[170],"to":[171,181],"information":[173],"from":[174,183],"cardiopulmonary":[176],"receptors":[178],"rather":[179],"that":[182],"high":[185],"receptors.":[187]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}