{"id":"https://openalex.org/W2415774491","doi":null,"title":"Comparison of various sources of antigen-presenting cells for the generation of GP2-tumor peptide specific cytotoxic T-lymphocytes.","display_name":"Comparison of various sources of antigen-presenting cells for the generation of GP2-tumor peptide specific cytotoxic T-lymphocytes.","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W2415774491","mag":"2415774491","pmid":"https://pubmed.ncbi.nlm.nih.gov/12530087"},"language":"en","primary_location":{"id":"pmid:12530087","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12530087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059284457","display_name":"Matthias Peiper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Peiper","raw_affiliation_strings":["Chirurgische Klinik, Universit\u00e4tsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. peiper@uke.uni-hamburg.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chirurgische Klinik, Universit\u00e4tsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. peiper@uke.uni-hamburg.de","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062157417","display_name":"Peter S. Goedegebuure","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter S Goedegebuure","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091103623","display_name":"Ingo Alldinger","orcid":"https://orcid.org/0000-0002-6856-4457","observed_orcids":["https://orcid.org/0000-0002-6856-4457"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ingo Alldinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083695901","display_name":"Wolfram Trudo Knoefel","orcid":"https://orcid.org/0000-0003-2472-8314","observed_orcids":["https://orcid.org/0000-0003-2472-8314"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wolfram Trudo Knoefel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039983309","display_name":"Jakob Robert Izbicki","orcid":"https://orcid.org/0000-0001-6807-8224","observed_orcids":["https://orcid.org/0000-0001-6807-8224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jakob R Izbicki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032371242","display_name":"Timothy J. Eberlein","orcid":"https://orcid.org/0009-0008-7076-2357","observed_orcids":["https://orcid.org/0009-0008-7076-2357"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy J Eberlein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.26886256,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"6A","first_page":"3357","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8690000176429749},{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tumor-antigens","display_name":"tumor antigens","score":0.33399999141693115},{"id":"https://openalex.org/keywords/epstein-barr-virus-transformed-b-cell-lines","display_name":"Epstein-Barr virus-transformed B cell lines","score":0.8259999752044678},{"id":"https://openalex.org/keywords/allogeneic-dendritic-cells","display_name":"allogeneic dendritic cells","score":0.8619999885559082},{"id":"https://openalex.org/keywords/t2-cells","display_name":"T2 cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/hla-a2-restriction","display_name":"HLA-A2 restriction","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.6890000104904175},{"id":"https://openalex.org/keywords/t-cell-mediated-immunity","display_name":"T cell immunity","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.772332489490509},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6826009750366211},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.6603974103927612},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.503109872341156},{"id":"https://openalex.org/C2776662205","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor antigen","level":4,"score":0.5017518997192383},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.5009589195251465},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4521102011203766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.450224369764328},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.445556640625},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4407212436199188},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4194340705871582},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35889729857444763},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3573283553123474},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.35133716464042664},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3252306580543518},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2785194516181946},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11123049259185791},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.050536900758743286},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12530087","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12530087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Comparative Study"},{"id":"mag:2415774491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12530087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1830105491","display_name":"IMMUNE RESPONSE TO OVARIAN CARCINOMA","funder_award_id":"R01CA060662","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2610200524","display_name":"T CELL IMMUNE RESPONSE TO BREAST CARCINOMA","funder_award_id":"R01CA068500","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2042121895","https://openalex.org/W2732246469","https://openalex.org/W208319294","https://openalex.org/W228212601","https://openalex.org/W1987815488","https://openalex.org/W2635890963","https://openalex.org/W2271615253","https://openalex.org/W1968608035","https://openalex.org/W2059094241","https://openalex.org/W2004671563"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,129,165,177,200],"need":[2],"for":[3,7,50,61,125],"new":[4],"therapeutic":[5],"regimens":[6],"cancer":[8,189,195],"has":[9],"led":[10],"to":[11,32,37,144,161,171,237],"the":[12,43,134],"identification":[13],"of":[14,45,55,118,152,157,175,179,185,202],"tumor":[15,137,203],"antigens":[16],"in":[17,30,191],"several":[18],"tumors.":[19],"Yet,":[20],"potent":[21],"antigen-presenting":[22,56,87],"cells":[23,57,69,72,88,160,196,204],"(APC)":[24,58],"are":[25],"being":[26],"identified":[27],"and":[28,73,82,100,121,216],"characterized":[29],"order":[31],"find":[33],"those":[34],"most":[35,150],"able":[36],"induce":[38],"T-cell-mediated":[39],"immunity.":[40],"To":[41,110],"facilitate":[42],"generation":[44],"cytotoxic":[46],"T-lymphocytes":[47],"(CTL)":[48],"specific":[49],"known":[51],"antigens,":[52],"various":[53],"sources":[54],"were":[59,84,94,123,131,197],"compared":[60],"their":[62],"efficiency.":[63],"MATERIALS":[64],"AND":[65],"METHODS:":[66],"Allogeneic":[67],"dendritic":[68,240],"(DC),":[70],"T2":[71,122,146,238],"two":[74],"Epstein":[75],"Barr":[76],"virus-transformed":[77],"B":[78,228],"cell":[79,229],"lines,":[80,230],"JY":[81],"TK-6,":[83],"used":[85,124],"as":[86,207],"(APC).":[89],"T-cells":[90],"from":[91,169],"normal":[92],"donors":[93],"stimulated":[95],"with":[96,102,133,183,212],"solid-phase":[97],"anti-CD3":[98],"antibody":[99],"reactivated":[101],"peptide-pulsed":[103],"APC":[104,130,153],"three":[105,126],"times":[106],"at":[107],"weekly":[108],"intervals.":[109],"minimize":[111],"any":[112],"potential":[113],"alloreactivity,":[114],"eighteen":[115],"random":[116],"combinations":[117,151,174],"JY,":[119],"TK6":[120],"peptide":[127,180],"stimulations.":[128],"pulsed":[132],"HLA-A2-binding":[135],"HER2/neu-derived":[136],"antigen":[138],"p654-662":[139],"(GP2).":[140],"RESULTS:":[141],"In":[142],"addition":[143],"either":[145],"or":[147,239],"DC":[148],"alone,":[149],"induced":[154],"significant":[155],"recognition":[156,181,184,201],"GP-2-pulsed":[158],"target":[159],"a":[162,234],"varying":[163],"degree.":[164],"stimulation":[166],"index":[167],"varied":[168],"0.5":[170],"8.1":[172],"using":[173,226],"APC.":[176],"level":[178],"correlated":[182],"HLA-A2+,":[186],"HER2/neu+":[187],"pancreatic":[188,194],"cells;":[190],"contrast,":[192],"HLA-A2-negative":[193],"not":[198],"recognized.":[199],"was":[205],"HLA-restricted":[206],"evidenced":[208],"by":[209],"blocking":[210],"studies":[211],"anti-HLA":[213],"class":[214],"I":[215],"anti-HLA-A2":[217],"antibodies.":[218],"CONCLUSION:":[219],"Tumor":[220],"peptide-specific":[221],"CTL":[222],"can":[223],"be":[224],"generated":[225],"allogeneic":[227],"which":[231],"may":[232],"provide":[233],"useful":[235],"alternative":[236],"cells.":[241]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
