{"id":"https://openalex.org/W2415766541","doi":"https://doi.org/10.1152/jappl.1995.79.3.812","title":"Neurochemical control of tissue resistance in piglets","display_name":"Neurochemical control of tissue resistance in piglets","publication_year":1995,"publication_date":"1995-09-01","ids":{"openalex":"https://openalex.org/W2415766541","doi":"https://doi.org/10.1152/jappl.1995.79.3.812","mag":"2415766541","pmid":"https://pubmed.ncbi.nlm.nih.gov/8567522"},"language":"en","primary_location":{"id":"doi:10.1152/jappl.1995.79.3.812","doi":"https://doi.org/10.1152/jappl.1995.79.3.812","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1995.79.3.812","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033749081","display_name":"Richard J. Martin","orcid":"https://orcid.org/0000-0003-2422-1847","observed_orcids":["https://orcid.org/0000-0003-2422-1847"]},"institutions":[{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. J. Martin","raw_affiliation_strings":["Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, Ohio 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, Ohio 44106, USA","institution_ids":["https://openalex.org/I4210151235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085808187","display_name":"Ismail A Dreshaj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. A. Dreshaj","raw_affiliation_strings":["Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, Ohio 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, Ohio 44106, USA","institution_ids":["https://openalex.org/I4210151235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000065386","display_name":"Martha J. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. J. Miller","raw_affiliation_strings":["Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, Ohio 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, Ohio 44106, USA","institution_ids":["https://openalex.org/I4210151235"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019717439","display_name":"Musa A. Haxhiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. A. Haxhiu","raw_affiliation_strings":["Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, Ohio 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, Ohio 44106, USA","institution_ids":["https://openalex.org/I4210151235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210151235"],"apc_list":null,"apc_paid":null,"fwci":0.7633,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.75521448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"3","first_page":"812","last_page":"817"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-resistance","display_name":"pulmonary resistance","score":0.7979999780654907},{"id":"https://openalex.org/keywords/tissue-resistance","display_name":"tissue resistance","score":0.9430000185966492},{"id":"https://openalex.org/keywords/airway-resistance","display_name":"airway resistance","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hypercapnia","display_name":"hypercapnia","score":0.925000011920929},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":1.0},{"id":"https://openalex.org/keywords/chemoreceptors","display_name":"chemoreceptors","score":0.875},{"id":"https://openalex.org/keywords/cholinergic-blockade","display_name":"cholinergic blockade","score":0.7480000257492065},{"id":"https://openalex.org/keywords/phrenic-nerve","display_name":"phrenic nerve","score":0.7940000295639038},{"id":"https://openalex.org/keywords/respiratory-system-development","display_name":"respiratory development","score":0.5019999742507935},{"id":"https://openalex.org/keywords/piglets","display_name":"piglets","score":0.902999997138977},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2777037550","wikidata":"https://www.wikidata.org/wiki/Q615759","display_name":"Hypercapnia","level":3,"score":0.829811692237854},{"id":"https://openalex.org/C33362165","wikidata":"https://www.wikidata.org/wiki/Q754455","display_name":"Airway resistance","level":3,"score":0.6627071499824524},{"id":"https://openalex.org/C103247709","wikidata":"https://www.wikidata.org/wiki/Q1069641","display_name":"Chemoreceptor","level":3,"score":0.635838508605957},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5811340808868408},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5654468536376953},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5245504379272461},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5102887153625488},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.5038999915122986},{"id":"https://openalex.org/C2777099253","wikidata":"https://www.wikidata.org/wiki/Q737313","display_name":"Phrenic nerve","level":3,"score":0.4795758128166199},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41702800989151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3656597435474396},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.3595593571662903},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3254757523536682},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25651466846466064},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.11461514234542847},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000403","descriptor_name":"Airway Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000403","descriptor_name":"Airway Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001286","descriptor_name":"Atropine Derivatives","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001784","descriptor_name":"Blood Gas Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010276","descriptor_name":"Parasympatholytics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010791","descriptor_name":"Phrenic Nerve","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010791","descriptor_name":"Phrenic Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011659","descriptor_name":"Pulmonary Gas Exchange","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/jappl.1995.79.3.812","doi":"https://doi.org/10.1152/jappl.1995.79.3.812","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1995.79.3.812","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:8567522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8567522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1314180389","display_name":null,"funder_award_id":"HL-25830","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2088245336","display_name":"Control of Respiratory Skeletal and Smooth Muscle","funder_award_id":"P01HL025830","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2685758313","display_name":"Airway-Central Nervous System Control","funder_award_id":"R01HL050527","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G473956629","display_name":null,"funder_award_id":"HL-50527-01A2","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1982127469","https://openalex.org/W2191841329","https://openalex.org/W2024358266","https://openalex.org/W2079313326","https://openalex.org/W2280626351","https://openalex.org/W2016431526","https://openalex.org/W2009828891","https://openalex.org/W1970672912","https://openalex.org/W2174072532","https://openalex.org/W2073135262"],"abstract_inverted_index":{"Lung":[0],"resistance":[1,42,46,64],"may":[2,197],"be":[3],"influenced":[4],"by":[5,10,178],"chemoreceptor":[6,130],"activity":[7,125],"and":[8,44,54,62,91,112,117,137,142,148,159,182],"modulated":[9,177],"inspiratory":[11,179],"neural":[12,180,191],"output;":[13],"however,":[14],"it":[15],"is":[16,176,183],"unknown":[17],"whether":[18],"the":[19,52,140,154,171,194],"contractile":[20],"elements":[21],"of":[22,57,68,102,145,174],"lung":[23,41],"tissue":[24,45,60],"participate":[25],"in":[26,109,115,121,126,166,190],"these":[27,135],"changes":[28],"during":[29,185,203],"early":[30,186,204],"development.":[31,187],"In":[32],"anesthetized":[33],"paralyzed":[34],"open-chest":[35],"piglets,":[36],"we":[37],"measured":[38],"phrenic":[39,124],"electroneurogram,":[40],"(RL),":[43],"utilizing":[47],"alveolar":[48,118],"capsules":[49],"to":[50,77,86,96,128,199],"partition":[51],"hypercapnic":[53,141],"hypoxic":[55,143],"responses":[56,144],"RL":[58,73],"into":[59],"(Rti)":[61],"airway":[63,172],"(Raw)":[65],"components.":[66],"Inhalation":[67,101],"7%":[69],"CO2":[70],"significantly":[71,138],"increased":[72],"(7.4":[74],"+/-":[75,79,84,88,94,98],"0.5":[76,85,89],"11.3":[78],"0.6":[80],"cmH2O.l-1.s),":[81,90],"Rti":[82,167],"(5.2":[83],"6.9":[87],"Raw":[92],"(2.2":[93],"0.2":[95],"4.4":[97],"0.4":[99],"cmH2O.l-1.s).":[100],"12%":[103],"O2":[104],"caused":[105],"more":[106],"modest":[107],"increases":[108],"RL,":[110,146,175],"Rti,":[111,147],"Raw.":[113,149],"Oscillations":[114],"tracheal":[116],"pressures":[119],"appeared":[120],"synchrony":[122],"with":[123],"response":[127],"both":[129],"stimuli.":[131],"Cholinergic":[132],"blockade":[133],"eliminated":[134],"oscillations":[136],"reduced":[139],"These":[150],"data":[151],"demonstrate":[152],"for":[153],"first":[155],"time":[156],"that":[157],"hypercapnia":[158],"hypoxia":[160],"elicit":[161],"a":[162],"cholinergically":[163],"mediated":[164],"increase":[165],"which,":[168],"just":[169],"like":[170],"component":[173],"output":[181],"present":[184],"Such":[188],"coordination":[189],"function":[192],"throughout":[193],"respiratory":[195],"system":[196],"serve":[198],"optimize":[200],"gas":[201],"exchange":[202],"postnatal":[205],"life.":[206]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
