{"id":"https://openalex.org/W2415752015","doi":null,"title":"The role of endogenous prostaglandins in clinically-used and investigational glaucoma therapy.","display_name":"The role of endogenous prostaglandins in clinically-used and investigational glaucoma therapy.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2415752015","mag":"2415752015","pmid":"https://pubmed.ncbi.nlm.nih.gov/2508130"},"language":"en","primary_location":{"id":"pmid:2508130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2508130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in clinical and biological research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039302002","display_name":"Carl B. Camras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C B Camras","raw_affiliation_strings":["Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110087364","display_name":"Steven M. Podos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S M Podos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2197,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.91732102,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"312","issue":null,"first_page":"459","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endogenous-prostaglandins","display_name":"endogenous prostaglandins","score":0.8920000195503235},{"id":"https://openalex.org/keywords/glaucoma-treatment","display_name":"glaucoma treatment","score":0.9509999752044678},{"id":"https://openalex.org/keywords/intraocular-pressure-reduction","display_name":"intraocular pressure reduction","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ocular-hypotensive-agents","display_name":"ocular hypotensive agents","score":0.9539999961853027},{"id":"https://openalex.org/keywords/prostaglandin-synthesis-inhibitors","display_name":"prostaglandin synthesis inhibitors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.8659999966621399},{"id":"https://openalex.org/keywords/flurbiprofen","display_name":"flurbiprofen","score":0.9769999980926514},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.8209999799728394},{"id":"https://openalex.org/keywords/alpha-lipoic-acid","display_name":"alpha-lipoic acid","score":0.6859999895095825},{"id":"https://openalex.org/keywords/sympathomimetic-drugs","display_name":"sympathomimetic drugs","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cholinergic-agonists","display_name":"cholinergic agonists","score":0.9779999852180481},{"id":"https://openalex.org/keywords/aqueous-humor","display_name":"aqueous humor","score":0.6859999895095825},{"id":"https://openalex.org/keywords/cyclocryotherapy","display_name":"cyclocryotherapy","score":0.921999990940094},{"id":"https://openalex.org/keywords/cycloplegic-agents","display_name":"cycloplegic agents","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.8061559200286865},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7976019382476807},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.5891033411026001},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5067771077156067},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46697020530700684},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.4552153944969177},{"id":"https://openalex.org/C2776521421","wikidata":"https://www.wikidata.org/wiki/Q9294051","display_name":"Ocular hypertension","level":3,"score":0.44225868582725525},{"id":"https://openalex.org/C2776740260","wikidata":"https://www.wikidata.org/wiki/Q634959","display_name":"Latanoprost","level":3,"score":0.4221782088279724},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.28918778896331787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27634692192077637},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005480","descriptor_name":"Flurbiprofen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053685","descriptor_name":"Laser Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2508130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2508130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in clinical and biological research","raw_type":"Journal Article"},{"id":"mag:2415752015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2508130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W57132350","https://openalex.org/W2019061802","https://openalex.org/W296276057","https://openalex.org/W1989343033","https://openalex.org/W2309193833","https://openalex.org/W7014153366","https://openalex.org/W2799627453","https://openalex.org/W199755225","https://openalex.org/W33564431","https://openalex.org/W1966229384"],"abstract_inverted_index":{"A":[0],"review":[1],"of":[2,40,72,96,127,211,227,235,251,265,270],"the":[3,76,94,125,175,225,246,271],"relevant":[4],"literature":[5],"strongly":[6],"suggests":[7],"that":[8,138,248],"several":[9],"medical":[10,231],"and":[11,19,55,68,107,133,209],"laser":[12],"treatments":[13,22],"presently":[14],"used":[15,273],"in":[16,29,64,75,79,109,145,148,194,205,223],"glaucoma":[17,149,182,236],"therapy,":[18],"other":[20,187],"potential":[21,221],"under":[23],"investigation,":[24],"reduce":[25,192],"IOP,":[26],"at":[27],"least,":[28],"part,":[30],"by":[31,61,99,196,230],"stimulating":[32,197],"endogenous":[33],"PG":[34,59,73,82,155,199],"synthesis.":[35,200],"There":[36],"are":[37,48,152,203,214],"four":[38],"lines":[39],"evidence":[41],"leading":[42],"to":[43,124],"this":[44],"conclusion.":[45],"(1)":[46],"PGs":[47,202,213],"potent":[49,216],"ocular":[50,62,207,217],"hypotensive":[51,218],"agents.":[52,277],"(2)":[53],"Adrenergic":[54],"cholinergic":[56],"agonists":[57],"stimulate":[58],"synthesis":[60,83,156],"tissues":[63,208],"vitro.":[65],"(3)":[66],"Epinephrine":[67],"ALT":[69,108],"cause":[70],"elevation":[71],"levels":[74],"aqueous":[77],"humor":[78],"vivo.":[80],"(4)":[81],"inhibitors":[84,157],"such":[85,128,159,183],"as":[86,131,160,184],"indomethacin":[87,163],"or":[88,91,162,174,186,232,256,275],"flurbiprofen":[89],"block,":[90],"partially":[92],"inhibit,":[93],"reduction":[95,226],"IOP":[97,147,193,228,267],"produced":[98,204,229],"epinephrine,":[100],"para-aminoclonidine,":[101],"forskolin,":[102],"vanadate,":[103],"verapamil,":[104],"arachidonic":[105],"acid,":[106],"rabbits,":[110],"cats,":[111],"monkeys,":[112],"and/or":[113],"humans.":[114],"This":[115],"last":[116],"finding":[117],"has":[118],"great":[119],"clinical":[120],"importance":[121],"with":[122],"regard":[123],"efficacy":[126],"treatment":[129],"modalities":[130,140,234],"epinephrine":[132],"ALT,":[134],"since":[135],"it":[136],"indicates":[137],"these":[139,212,243],"may":[141,190,259],"be":[142,240],"less":[143],"effective":[144],"reducing":[146],"patients":[150],"who":[151],"taking":[153],"systemic":[154],"-":[158,164],"aspirin":[161],"for":[165,181],"arthritis,":[166],"cerebrovascular":[167],"disease,":[168,172],"arteriosclerotic":[169],"coronary":[170],"vascular":[171],"headache,":[173],"common":[176],"cold.":[177],"Other":[178],"surgical":[179,233],"procedures":[180,189,274],"cyclocryotherapy":[185],"cyclodestructive":[188],"also":[191],"part":[195],"local":[198],"Since":[201],"various":[206],"some":[210,269],"highly":[215],"agents,":[219],"their":[220],"role":[222],"mediating":[224],"therapy":[237],"must":[238],"always":[239],"considered.":[241],"Furthermore,":[242],"considerations":[244],"support":[245],"concept":[247],"topical":[249],"application":[250],"an":[252],"appropriately":[253],"selected":[254],"PG,":[255],"its":[257],"derivative,":[258],"provide":[260],"a":[261],"more":[262],"direct":[263],"means":[264],"lowering":[266],"than":[268],"currently":[272],"therapeutic":[276]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}