{"id":"https://openalex.org/W2415552373","doi":null,"title":"Phase I trial of recombinant interferon gamma by 1-hour i.v. infusion.","display_name":"Phase I trial of recombinant interferon gamma by 1-hour i.v. infusion.","publication_year":1986,"publication_date":"1986-05-01","ids":{"openalex":"https://openalex.org/W2415552373","mag":"2415552373","pmid":"https://pubmed.ncbi.nlm.nih.gov/3085930"},"language":"en","primary_location":{"id":"pmid:3085930","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3085930","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment reports","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009177808","display_name":"Saroj Vadhan\u2010Raj","orcid":"https://orcid.org/0000-0002-6790-8457","observed_orcids":["https://orcid.org/0000-0002-6790-8457"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Vadhan-Raj","raw_affiliation_strings":["Sarcoma Medical Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Medical Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111703724","display_name":"C F Nathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C F Nathan","raw_affiliation_strings":["Memorial-Sloan Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial-Sloan Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108288352","display_name":"Stephen A. Sherwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S A Sherwin","raw_affiliation_strings":["Memorial-Sloan Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial-Sloan Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031408449","display_name":"Herbert Friedrich Oettgen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H F Oettgen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050919683","display_name":"Susan E. Krown","orcid":"https://orcid.org/0000-0003-3395-062X","observed_orcids":["https://orcid.org/0000-0003-3395-062X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S E Krown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2969,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.89589954,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"70","issue":"5","first_page":"609","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.61080002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.61080002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.13259999454021454,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.044199999421834946,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-interferon-gamma","display_name":"recombinant interferon-gamma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/intravenous-infusion","display_name":"intravenous infusion","score":0.7310000061988831},{"id":"https://openalex.org/keywords/infusion-time","display_name":"infusion duration","score":0.6060000061988831},{"id":"https://openalex.org/keywords/advanced-cancer","display_name":"advanced cancer","score":0.8539999723434448},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8550000190734863},{"id":"https://openalex.org/keywords/serum-triglycerides","display_name":"serum triglycerides","score":0.824999988079071},{"id":"https://openalex.org/keywords/serum-interferon-levels","display_name":"serum interferon levels","score":0.7829999923706055},{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.8259999752044678},{"id":"https://openalex.org/keywords/b-cell-malignancies","display_name":"B-cell malignancies","score":0.8360000252723694},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.8299999833106995},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9333561658859253},{"id":"https://openalex.org/C2778594517","wikidata":"https://www.wikidata.org/wiki/Q2260058","display_name":"Chills","level":2,"score":0.7586681246757507},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6302970051765442},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.47788918018341064},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.41494375467300415},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40881508588790894},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4053225517272949},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34302788972854614},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.26146918535232544},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001613","descriptor_name":"beta 2-Microglobulin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001772","descriptor_name":"Blood Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004274","descriptor_name":"DNA, Recombinant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007263","descriptor_name":"Infusions, Parenteral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008079","descriptor_name":"Lipoproteins, VLDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3085930","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3085930","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment reports","raw_type":"Clinical Trial"},{"id":"mag:2415552373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3085930","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2290526514","https://openalex.org/W2418886374","https://openalex.org/W2022515405","https://openalex.org/W2469388094","https://openalex.org/W2174763255","https://openalex.org/W2182859076","https://openalex.org/W2171612134","https://openalex.org/W2416729798","https://openalex.org/W2411410597","https://openalex.org/W2411730384"],"abstract_inverted_index":{"Fifteen":[0],"patients":[1],"with":[2,7,138,153],"advanced":[3],"malignancy":[4],"were":[5,50,61,82,116],"treated":[6],"recombinant":[8],"interferon":[9,106],"gamma":[10],"(rIFN-gamma)":[11],"(specific":[12],"activity":[13,127],"approximately":[14],"2":[15,130],"X":[16],"10(7)":[17],"units/mg,":[18],"purity":[19],"greater":[20],"than":[21,64,188],"99%)":[22],"given":[23,190],"by":[24,176,191],"1-hour":[25],"iv":[26,70,178,193],"infusion":[27,114,179],"three":[28],"times":[29],"a":[30,88],"week":[31],"for":[32],"6":[33],"weeks,":[34],"at":[35,109],"fixed":[36],"dose":[37,99],"levels":[38,107,158],"of":[39,112,144,159,167],"0.1,":[40],"0.5,":[41],"1.0,":[42],"or":[43],"2.0":[44],"mg/m2/day.":[45,103],"The":[46,95],"common":[47],"side":[48],"effects":[49],"constitutional":[51],"symptoms,":[52],"including":[53],"fever,":[54],"chills,":[55],"myalgias,":[56],"and":[57,78,115,124,162,184],"headache,":[58],"but":[59,85],"these":[60],"less":[62,186],"severe":[63],"those":[65],"observed":[66],"following":[67],"daily":[68],"6-hour":[69],"infusions.":[71],"Significant":[72],"changes":[73],"in":[74,91,156],"blood":[75,169],"cell":[76],"counts":[77],"routine":[79],"serum":[80,92,105,123,157],"chemistries":[81],"not":[83],"observed,":[84],"there":[86],"was":[87,101,119,128,151],"dose-dependent":[89],"increase":[90,155],"triglyceride":[93],"levels.":[94],"maximum":[96],"safely":[97],"tolerated":[98],"achieved":[100],"1.0":[102],"Peak":[104],"occurred":[108],"the":[110,113,133,148,163],"midpoint":[111],"dose-dependent.":[117],"rIFN-gamma":[118,174],"rapidly":[120],"cleared":[121],"from":[122],"no":[125],"detectable":[126],"found":[129],"hours":[131],"after":[132],"infusion.":[134,194],"Two":[135],"patients,":[136],"both":[137],"B-cell":[139],"malignancies,":[140],"showed":[141],"objective":[142],"evidence":[143],"tumor":[145],"regression":[146],"during":[147],"treatment.":[149],"Treatment":[150],"associated":[152],"an":[154],"beta":[160],"2-microglobulin":[161],"H2O2":[164],"secretory":[165],"capacity":[166],"peripheral":[168],"monocytes.":[170],"We":[171],"conclude":[172],"that":[173],"administered":[175],"short":[177],"can":[180],"induce":[181],"biological":[182],"activities":[183],"causes":[185],"toxicity":[187],"when":[189],"prolonged":[192]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}