{"id":"https://openalex.org/W2415532012","doi":null,"title":"The Sa system: a novel antigen-antibody system specific for rheumatoid arthritis.","display_name":"The Sa system: a novel antigen-antibody system specific for rheumatoid arthritis.","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W2415532012","mag":"2415532012","pmid":"https://pubmed.ncbi.nlm.nih.gov/7932409"},"language":"en","primary_location":{"id":"pmid:7932409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7932409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070736449","display_name":"N. Despr\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"N Despr\u00e9s","raw_affiliation_strings":["Rheumatic Diseases Unit, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Sherbrooke, PQ, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatic Diseases Unit, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Sherbrooke, PQ, Canada","institution_ids":["https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023988126","display_name":"Gilles Boire","orcid":"https://orcid.org/0000-0003-2481-5821","observed_orcids":["https://orcid.org/0000-0003-2481-5821"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Boire","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059618465","display_name":"F. Javier L\u00f3pez-Longo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F J Lopez-Longo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110835200","display_name":"Henri Andr\u00e9 M\u00e9nard","orcid":"https://orcid.org/0000-0002-0361-0934","observed_orcids":["https://orcid.org/0000-0002-0361-0934"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H A M\u00e9nard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3375,"has_fulltext":false,"cited_by_count":179,"citation_normalized_percentile":{"value":0.92805383,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"21","issue":"6","first_page":"1027","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-sa-antibodies","display_name":"anti-Sa antibodies","score":0.9940000176429749},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/serological-markers","display_name":"serological markers","score":0.7129999995231628},{"id":"https://openalex.org/keywords/rheumatoid-factor","display_name":"rheumatoid factor","score":0.9010000228881836},{"id":"https://openalex.org/keywords/connective-tissue-diseases","display_name":"connective tissue diseases","score":0.7360000014305115},{"id":"https://openalex.org/keywords/diagnostic-specificity","display_name":"diagnostic specificity","score":0.675000011920929},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.6480000019073486},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8800127506256104},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.74861079454422},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7434687614440918},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7309685945510864},{"id":"https://openalex.org/C2776232647","wikidata":"https://www.wikidata.org/wiki/Q702883","display_name":"Rheumatoid factor","level":3,"score":0.6865648031234741},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6603432893753052},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.5767384767532349},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.5018956661224365},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.48145097494125366},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.47630560398101807},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.47162604331970215},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.45115625858306885},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.43586423993110657},{"id":"https://openalex.org/C2776670291","wikidata":"https://www.wikidata.org/wiki/Q1779300","display_name":"Connective tissue disease","level":4,"score":0.42701587080955505},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.2033127248287201}],"mesh":[{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:7932409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7932409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},{"id":"mag:2415532012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7932409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2140421561","https://openalex.org/W2411535822","https://openalex.org/W2391841831","https://openalex.org/W76382802","https://openalex.org/W2354776863","https://openalex.org/W2390413835","https://openalex.org/W382113376","https://openalex.org/W2395178322","https://openalex.org/W4241049659","https://openalex.org/W7109458380"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"describe":[2],"a":[3,196,223,262],"novel":[4,224],"autoimmune":[5,217],"system":[6],"(Sa/anti-Sa)":[7],"specific":[8,63,228],"for":[9,163,229],"rheumatoid":[10,97,273],"arthritis":[11],"(RA).":[12],"METHODS:":[13],"Antibodies":[14,128],"were":[15,41,93,115,131,176],"detected":[16],"in":[17,69,83,96,105,118,134,145,203,261],"immunoblots":[18,70],"using":[19],"human":[20,205],"spleen":[21,72],"and":[22,104,207],"placenta":[23,74],"extracts":[24],"as":[25,35,37,195,242,254,256],"antigens.":[26],"Sera":[27,52],"from":[28,38,53,136,185,211],"482":[29],"patients":[30,59,81,108,121,137,147,266],"with":[31,60,109,122,138,182,267],"various":[32],"rheumatic":[33],"diseases":[34,126],"well":[36,255],"healthy":[39],"controls":[40],"evaluated":[42],"to":[43,129,187],"define":[44],"the":[45,84,153,179,251,272],"disease":[46,89],"associations":[47],"of":[48,55,71,78,160,178,236,250,265,271],"anti-Sa":[49,161,232],"antibodies.":[50],"RESULTS:":[51],"88":[54],"206":[56],"(42.7%)":[57],"unselected":[58],"RA":[61,110,139,164,215],"recognized":[62],"protein":[64,199],"bands":[65],"(the":[66],"Sa":[67,130,191,252],"antigen)":[68],"or":[73,102,112],"extracts,":[75],"including":[76],"9":[77],"31":[79],"(29%)":[80],"seen":[82],"first":[85],"few":[86],"months":[87],"after":[88],"onset.":[90],"Anti-Sa":[91,174,220],"antibodies":[92,162,175,221,233],"found":[94,133,143],"both":[95],"factor":[98],"(RF)":[99],"negative":[100,169],"(17/63":[101],"27%)":[103],"RF":[106,119],"positive":[107,120,157],"(71/143":[111],"50%).":[113],"They":[114],"nevertheless":[116],"absent":[117],"other":[123],"connective":[124],"tissue":[125],"(0/39).":[127],"essentially":[132],"sera":[135],"(specificity":[140],"98.9%)":[141],"being":[142],"only":[144],"3":[146],"whose":[148],"arthritides":[149],"did":[150],"not":[151],"fulfill":[152],"ACR":[154],"criteria.":[155],"The":[156,190,247],"predictive":[158,170],"value":[159,171],"was":[165,172,193],"96.7%,":[166],"while":[167],"its":[168,257],"69.8%.":[173],"predominantly":[177],"IgG":[180],"isotype,":[181],"titers":[183],"varying":[184],"1/50":[186],">":[188],"1/1000.":[189],"antigen":[192,253],"characterized":[194],"poorly":[197],"soluble":[198],"that":[200,208],"is":[201,209],"present":[202],"normal":[204],"tissues":[206],"distinct":[210],"all":[212],"previously":[213],"described":[214],"associated":[216],"systems.":[218],"CONCLUSION:":[219],"are":[222],"serological":[225],"marker":[226],"highly":[227],"RA.":[230],"Since":[231],"occur":[234],"independently":[235],"RF,":[237],"they":[238],"can":[239],"be":[240],"used":[241],"an":[243],"additional":[244],"diagnostic":[245],"tool.":[246],"molecular":[248],"nature":[249],"potential":[258],"pathogenic":[259],"role":[260],"significant":[263],"proportion":[264],"chronic":[268],"articular":[269],"inflammation":[270],"variety":[274],"merit":[275],"further":[276],"definition.":[277]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
