{"id":"https://openalex.org/W2415522575","doi":"https://doi.org/10.1152/jappl.1983.55.2.462","title":"Effects of cyclooxygenase and lipoxygenase inhibition on lung fluid balance after thrombin","display_name":"Effects of cyclooxygenase and lipoxygenase inhibition on lung fluid balance after thrombin","publication_year":1983,"publication_date":"1983-08-01","ids":{"openalex":"https://openalex.org/W2415522575","doi":"https://doi.org/10.1152/jappl.1983.55.2.462","mag":"2415522575","pmid":"https://pubmed.ncbi.nlm.nih.gov/6413464"},"language":"en","primary_location":{"id":"doi:10.1152/jappl.1983.55.2.462","doi":"https://doi.org/10.1152/jappl.1983.55.2.462","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1983.55.2.462","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107964609","display_name":"Rena Bizios","orcid":"https://orcid.org/0000-0003-2939-4632","observed_orcids":["https://orcid.org/0000-0003-2939-4632"]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Bizios","raw_affiliation_strings":["","Albany Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Albany Medical College","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052846902","display_name":"Fred L. Minnear","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. L. Minnear","raw_affiliation_strings":["","Albany Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Albany Medical College","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077465646","display_name":"Hoyte van der Zee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. van der Zee","raw_affiliation_strings":["","Albany Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Albany Medical College","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011756238","display_name":"Asrar B. Malik","orcid":"https://orcid.org/0000-0002-8205-7128","observed_orcids":["https://orcid.org/0000-0002-8205-7128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. B. Malik","raw_affiliation_strings":["","Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2621,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.78259093,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"55","issue":"2","first_page":"462","last_page":"471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.21699999272823334,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.21699999272823334,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.15539999306201935,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.14329999685287476,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lipoxygenase-inhibition","display_name":"lipoxygenase inhibition","score":0.9589999914169312},{"id":"https://openalex.org/keywords/alpha-thrombin","display_name":"alpha-thrombin","score":0.8989999890327454},{"id":"https://openalex.org/keywords/pulmonary-microembolism","display_name":"pulmonary microembolism","score":0.925000011920929},{"id":"https://openalex.org/keywords/pulmonary-lymph-flow","display_name":"lung lymph flow","score":0.699999988079071},{"id":"https://openalex.org/keywords/pulmonary-vascular-permeability","display_name":"pulmonary vascular permeability","score":0.7590000033378601},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ketoprofen","display_name":"ketoprofen","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bw755c","display_name":"BW755C","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pulmonary-artery-pressure","display_name":"pulmonary artery pressure","score":0.7440000176429749},{"id":"https://openalex.org/keywords/pulmonary-vascular-resistance","display_name":"pulmonary vascular resistance","score":0.9269999861717224},{"id":"https://openalex.org/keywords/pulmonary-capillary-pressure","display_name":"pulmonary capillary pressure","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.8584166765213013},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5951541066169739},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5171660780906677},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.5129911303520203},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.5078561902046204},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4816776216030121},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4672429859638214},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.4312351644039154},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.33293282985687256},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32293352484703064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3180210590362549},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23013976216316223},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14132791757583618}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007660","descriptor_name":"Ketoprofen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007660","descriptor_name":"Ketoprofen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007660","descriptor_name":"Ketoprofen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015772","descriptor_name":"4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015772","descriptor_name":"4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015772","descriptor_name":"4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/jappl.1983.55.2.462","doi":"https://doi.org/10.1152/jappl.1983.55.2.462","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1983.55.2.462","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:6413464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6413464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology: respiratory, environmental and exercise physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2396310016","https://openalex.org/W2193932911","https://openalex.org/W1974034442","https://openalex.org/W2150666992","https://openalex.org/W2017164377","https://openalex.org/W2058697385","https://openalex.org/W2035216666","https://openalex.org/W2434923528","https://openalex.org/W2403750641","https://openalex.org/W2045007030"],"abstract_inverted_index":{"We":[0,204],"examined":[1],"the":[2,5,11,73,80,90,132,168,180,200,211,220,235,244,248,265,269,284],"roles":[3],"of":[4,23,87,222,226,261],"cyclooxygenase":[6,197,228,278],"and":[7,16,37,46,65,104,135,174,192,229,268,279,290],"lipoxygenase":[8,207,230,280],"pathways":[9,263,281],"in":[10,13,63,70,72,112,120,131,163,167,182,186,202,213,215,234,238,243,250,257,272,286],"alterations":[12],"lung":[14,143],"fluid":[15,289],"protein":[17,114,291],"exchange":[18],"after":[19,51,165,184,240,293],"pulmonary":[20,33,39,96,157,287],"microembolism.":[21],"Infusion":[22],"alpha-thrombin":[24],"(T)":[25],"(55":[26],"+/-":[27],"13":[28],"U/kg)":[29],"immediately":[30],"increased":[31,95,125,172,190],"mean":[32,38],"arterial":[34],"pressure":[35,159],"(Ppa)":[36],"vascular":[40,144],"resistance":[41],"(PVR),":[42],"but":[43,247],"both":[44,227,262],"Ppa":[45,64,71],"PVR":[47],"waned":[48],"with":[49,55,108,254],"time":[50],"T.":[52,88],"Cyclooxygenase":[53],"inhibition":[54,198,260],"either":[56],"indomethacin":[57],"or":[58],"ketoprofen":[59],"produced":[60],"sustained":[61],"increases":[62,69,285],"PVR.":[66],"The":[67,140,274],"initial":[68],"cyclooxygenase-inhibited":[74,121],"groups":[75,188,217],"(CI)":[76,122],"were":[77],"matched":[78],"to":[79,102,127,155,210,283],"control":[81,91,133,169,245],"group":[82,170],"by":[83,100,148,218],"administering":[84],"greater":[85,128,270],"amounts":[86],"In":[89,118],"group,":[92,134,246],"T":[93,166,185,241],"rapidly":[94],"lymph":[97],"flow":[98],"(Qlym)":[99],"two-":[101],"threefold,":[103],"this":[105],"was":[106,146,252],"associated":[107,253],"a":[109,150,255],"steady":[110],"increase":[111,162,181,201,212,237,249,267,271],"lymph-to-plasma":[113],"concentration":[115],"ratio":[116],"(L/P).":[117],"contrast,":[119],"groups,":[123],"Qlym":[124,173,191,214,239,251],"gradually":[126],"levels":[129],"than":[130],"L/P":[136],"did":[137,175],"not":[138,176],"change.":[139],"effect":[141],"on":[142],"permeability":[145,266],"determined":[147,205],"inflating":[149],"left":[151],"atrial":[152],"balloon":[153],"catheter":[154],"raise":[156],"capillary":[158],"(Pc).":[160],"An":[161],"Pc":[164,183],"further":[171,189],"change":[177],"L/P,":[178,194],"whereas":[179],"CI":[187,216],"decreased":[193],"indicating":[195],"that":[196,277],"prevented":[199,264],"permeability.":[203],"whether":[206],"activation":[208],"contributed":[209],"examining":[219],"effects":[221],"BW755C,":[223],"an":[224],"inhibitor":[225],"pathways.":[231],"BW755C":[232],"resulted":[233],"same":[236],"as":[242],"decrease":[256],"L/P.":[258],"Therefore,":[259],"Qlym.":[273],"results":[275],"indicate":[276],"contribute":[282],"transvascular":[288],"fluxes":[292],"thrombin.":[294]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-09-22T17:25:34.749102","created_date":"2016-06-24T00:00:00"}