{"id":"https://openalex.org/W2415448222","doi":null,"title":"Epirubicin is equivalent to adriamycin in vitro against many cancer cells but more effective against gastric cancer cells.","display_name":"Epirubicin is equivalent to adriamycin in vitro against many cancer cells but more effective against gastric cancer cells.","publication_year":1992,"publication_date":"1992-03-01","ids":{"openalex":"https://openalex.org/W2415448222","mag":"2415448222","pmid":"https://pubmed.ncbi.nlm.nih.gov/1580555"},"language":"en","primary_location":{"id":"pmid:1580555","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1580555","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015256371","display_name":"Shunji Kohnoe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Kohnoe","raw_affiliation_strings":["Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088408014","display_name":"Masaki Yoshida","orcid":"https://orcid.org/0000-0002-4744-2805","observed_orcids":["https://orcid.org/0000-0002-4744-2805"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Yoshida","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046684935","display_name":"Isao Takahashi","orcid":"https://orcid.org/0000-0002-6857-9050","observed_orcids":["https://orcid.org/0000-0002-6857-9050"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"I Takahashi","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109526718","display_name":"Emi Y","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Emi","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113607160","display_name":"Yoshihko Maehara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Maehara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5057146510","display_name":"Keishi Sugimachi","orcid":"https://orcid.org/0000-0001-8768-5388","observed_orcids":["https://orcid.org/0000-0001-8768-5388"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Sugimachi","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.335,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.4635293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"2","first_page":"389","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.06509999930858612,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.024900000542402267,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epirubicin","display_name":"epirubicin","score":1.0},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/anthracycline-derivatives","display_name":"anthracycline derivatives","score":0.8190000057220459},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.7630000114440918},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.7770000100135803},{"id":"https://openalex.org/keywords/succinate-dehydrogenase-inhibition","display_name":"succinate dehydrogenase inhibition","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8040000200271606},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5839999914169312},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.6909999847412109},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9509999752044678},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7666534185409546},{"id":"https://openalex.org/C2780835546","wikidata":"https://www.wikidata.org/wiki/Q425122","display_name":"Epirubicin","level":4,"score":0.6825976967811584},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6453844904899597},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6311092972755432},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5499722957611084},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5260474681854248},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.4805205762386322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47816142439842224},{"id":"https://openalex.org/C2778076430","wikidata":"https://www.wikidata.org/wiki/Q5090616","display_name":"Chemosensitivity assay","level":3,"score":0.42288002371788025},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4196755886077881},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3901519775390625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35018524527549744},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33448946475982666},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28459542989730835},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.22834685444831848},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08954823017120361}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015251","descriptor_name":"Epirubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1580555","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1580555","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2415448222","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1580555","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2403739607","https://openalex.org/W2415947505","https://openalex.org/W2417392416","https://openalex.org/W2010746319","https://openalex.org/W2005293652","https://openalex.org/W2419024183","https://openalex.org/W2385994488","https://openalex.org/W2440354665","https://openalex.org/W2307537822","https://openalex.org/W2390991979"],"abstract_inverted_index":{"We":[0],"compared":[1],"the":[2,46,70,80,91,97,104,142,145,152],"cytotoxic":[3,168,178],"effects":[4],"of":[5,49,58,96,103,140,144,150],"two":[6],"anthracycline":[7],"derivatives,":[8],"epirubicin":[9],"(EPI)":[10],"and":[11,35,121,147,164],"adriamycin":[12],"(ADM),":[13],"against":[14],"human":[15],"tumor":[16,21,41,60,98,171],"cells":[17,42,125],"in":[18,71,90,199],"vitro.":[19],"Various":[20],"specimens,":[22],"obtained":[23],"at":[24],"surgery,":[25],"included":[26],"57":[27],"liver,":[28],"19":[29],"lung,":[30],"16":[31],"gastric,":[32],"10":[33],"colorectal":[34],"7":[36],"breast":[37],"cancer":[38,114,124,183,200],"specimens.":[39],"These":[40],"were":[43,126],"exposed":[44],"to":[45,63,79,101,119,129,132,169,181,189],"same":[47],"concentration":[48],"EPI":[50,120,130,163,175,186,195],"or":[51,87],"ADM":[52,133,165,180,198],"for":[53,112],"3":[54],"days.":[55],"The":[56,138],"chemosensitivity":[57],"each":[59,64,170],"cell":[61,109,172],"type":[62],"drug":[65],"was":[66,82,116,154],"then":[67],"assayed":[68],"using":[69],"vitro":[72],"succinate":[73,92],"dehydrogenase":[74,93],"inhibition":[75],"(SDI)":[76],"test.":[77],"Sensitivity":[78],"treatment":[81],"defined":[83],"as":[84],"a":[85],"50%":[86],"greater":[88],"reduction":[89],"(SD)":[94],"activity":[95],"cells,":[99,115],"relative":[100],"that":[102,162],"control":[105],"(untreated)":[106],"cells.":[107,184],"Each":[108],"type,":[110,173],"except":[111],"gastric":[113,182],"equally":[117,167],"sensitive":[118,128],"ADM.":[122],"Gastric":[123],"more":[127,177],"than":[131,136,179,193],"(P":[134],"less":[135,191],"0.05).":[137],"rate":[139],"coincidence,":[141],"sum":[143],"co-sensitive":[146],"co-resistant":[148],"rates":[149],"all":[151],"tumors,":[153],"quite":[155],"high":[156],"(90.8%).":[157],"Thus,":[158],"these":[159],"findings":[160],"indicate":[161],"are":[166],"but":[174],"is":[176,187],"Since":[185],"reported":[188],"be":[190],"cardiotoxic":[192],"ADM,":[194],"may":[196],"replace":[197],"chemotherapy.":[201]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
