{"id":"https://openalex.org/W2415445784","doi":null,"title":"The role of serum chromogranin A in diarrhoea predominant irritable bowel syndrome.","display_name":"The role of serum chromogranin A in diarrhoea predominant irritable bowel syndrome.","publication_year":2009,"publication_date":"2009-03-01","ids":{"openalex":"https://openalex.org/W2415445784","mag":"2415445784","pmid":"https://pubmed.ncbi.nlm.nih.gov/19337629"},"language":"en","primary_location":{"id":"pmid:19337629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19337629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal and liver diseases : JGLD","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075169684","display_name":"Reena Sidhu","orcid":"https://orcid.org/0000-0003-0820-2400","observed_orcids":["https://orcid.org/0000-0003-0820-2400"]},"institutions":[{"id":"https://openalex.org/I2801732343","display_name":"Royal Hallamshire Hospital","ror":"https://ror.org/00514rc81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801732343","https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Reena Sidhu","raw_affiliation_strings":["Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom. reena_sidhu@yahoo.com","Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom. reena_sidhu@yahoo.com","institution_ids":["https://openalex.org/I2801732343"]},{"raw_affiliation_string":"Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I2801732343"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067628638","display_name":"Mark Edward McAlindon","orcid":"https://orcid.org/0000-0003-0985-3643","observed_orcids":["https://orcid.org/0000-0003-0985-3643"]},"institutions":[{"id":"https://openalex.org/I2801732343","display_name":"Royal Hallamshire Hospital","ror":"https://ror.org/00514rc81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801732343","https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark E McAlindon","raw_affiliation_strings":["Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I2801732343"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079163326","display_name":"John Samuel Leeds","orcid":"https://orcid.org/0000-0002-5140-6225","observed_orcids":["https://orcid.org/0000-0002-5140-6225"]},"institutions":[{"id":"https://openalex.org/I2801732343","display_name":"Royal Hallamshire Hospital","ror":"https://ror.org/00514rc81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801732343","https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John S Leeds","raw_affiliation_strings":["Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I2801732343"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003444070","display_name":"Jessica Skilling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801732343","display_name":"Royal Hallamshire Hospital","ror":"https://ror.org/00514rc81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801732343","https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jessica Skilling","raw_affiliation_strings":["Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I2801732343"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037195356","display_name":"David Surendran Sanders","orcid":"https://orcid.org/0000-0002-3739-0124","observed_orcids":["https://orcid.org/0000-0002-3739-0124"]},"institutions":[{"id":"https://openalex.org/I2801732343","display_name":"Royal Hallamshire Hospital","ror":"https://ror.org/00514rc81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801732343","https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David S Sanders","raw_affiliation_strings":["Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I2801732343"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801732343"],"apc_list":null,"apc_paid":null,"fwci":3.5375,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.9213442,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"1","first_page":"23","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromogranin-a","display_name":"chromogranin A","score":0.8999999761581421},{"id":"https://openalex.org/keywords/diarrhea-predominant-irritable-bowel-syndrome","display_name":"diarrhea-predominant irritable bowel syndrome","score":0.9750000238418579},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.718999981880188},{"id":"https://openalex.org/keywords/octreotide-therapy","display_name":"octreotide therapy","score":0.9710000157356262},{"id":"https://openalex.org/keywords/carcinoid-syndrome","display_name":"carcinoid syndrome","score":0.5789999961853027},{"id":"https://openalex.org/keywords/gastric-adenocarcinoma","display_name":"gastric adenocarcinoma","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9232085943222046},{"id":"https://openalex.org/C77231918","wikidata":"https://www.wikidata.org/wiki/Q3698322","display_name":"Chromogranin A","level":3,"score":0.9093247056007385},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.7972245216369629},{"id":"https://openalex.org/C2781025020","wikidata":"https://www.wikidata.org/wiki/Q419935","display_name":"Octreotide","level":3,"score":0.7780056595802307},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7476386427879333},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7277929782867432},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6672403812408447},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.2523421049118042},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.10733607411384583},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005765","descriptor_name":"Gastrointestinal Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015282","descriptor_name":"Octreotide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D053379","descriptor_name":"Chromogranin A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:19337629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19337629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal and liver diseases : JGLD","raw_type":"Journal Article"},{"id":"mag:2415445784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19337629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1516141972","https://openalex.org/W1939038096","https://openalex.org/W1974565336","https://openalex.org/W2012442346","https://openalex.org/W2018162620","https://openalex.org/W2026207706","https://openalex.org/W2065019547","https://openalex.org/W2076438268","https://openalex.org/W2077107453","https://openalex.org/W2130505437","https://openalex.org/W2328752714","https://openalex.org/W2412891050"],"related_works":["https://openalex.org/W2077706903","https://openalex.org/W2059269695","https://openalex.org/W1983650058","https://openalex.org/W1984598136","https://openalex.org/W2055418738","https://openalex.org/W1998653324","https://openalex.org/W2076364853","https://openalex.org/W7099719883","https://openalex.org/W2397485719","https://openalex.org/W4414533316"],"abstract_inverted_index":{"BACKGROUND":[0],"&":[1],"AIMS:":[2],"Elevated":[3],"serum":[4],"chromogranin":[5],"A":[6],"(CgA)":[7],"levels":[8,72,110,123,136,153,183,205],"have":[9],"been":[10],"reported":[11],"co-incidentally":[12],"in":[13,34,197,211,217],"a":[14,48,143],"small":[15],"group":[16],"of":[17,31,104,131,168,187,199],"irritable":[18],"bowel":[19],"syndrome":[20],"(IBS)":[21],"patients":[22,41,93,106,149,178,218],"(n=19).":[23],"Our":[24],"aim":[25],"was":[26,193],"to":[27,207],"ascertain":[28],"the":[29,147,161],"prevalence":[30],"elevated":[32,79,151,181,210],"CgA":[33,71,80,109,122,129,135,152,182,200,204,216],"diarrhoea":[35],"predominant":[36],"Rome":[37,56],"II":[38,57],"IBS":[39,105],"(D-IBS)":[40],"and":[42,62,78,176,201],"investigate":[43],"if":[44],"this":[45],"could":[46],"be":[47,208],"marker":[49],"for":[50,83],"octreotide":[51,89,192,230],"therapy.":[52,90,231],"METHODS:":[53],"Patients":[54,74],"with":[55,75,127,150,185,219],"D-IBS":[58,221],"were":[59,81,94,165],"recruited":[60,95],"prospectively":[61],"investigated":[63],"as":[64],"per":[65],"British":[66],"Society":[67],"Guidelines":[68],"including":[69],"serial":[70],"(u/l).":[73],"refractory":[76,220],"symptoms":[77],"considered":[82],"further":[84],"investigation":[85],"+":[86],"or":[87],"-":[88],"RESULTS:":[91],"219":[92],"(68%":[96],"females,":[97],"mean":[98],"age":[99],"45":[100],"years).":[101],"81%":[102],"(n=177)":[103],"had":[107,115,121,133,142,179],"normal":[108],"(0-20u/l).":[111],"Whilst":[112],"12.3%":[113],"(n=27)":[114],"values":[116],"between":[117],"20-60u/l,":[118],"6.8%":[119],"(n=15)":[120],">60u/l;":[124],"96%":[125],"(26/27)":[126],"initial":[128],"level":[130],"20-60u/l":[132],"repeated":[134,158],"which":[137,195],"normalised.":[138],"One":[139],"patient":[140],"(3.7%)":[141],"gastric":[144,171],"adenocarcinoma.":[145],"In":[146,160,189],"15":[148],">60u/l,":[154],"8":[155],"normalised":[156],"on":[157],"testing.":[159],"other":[162],"7,":[163],"there":[164],"no":[166],"cases":[167],"carcinoid,":[169],"n=1":[170,173],"leiomyoma,":[172],"rectal":[174],"tumour":[175],"4":[177],"persistently":[180],"but":[184],"improvement":[186],"symptoms.":[188,202],"one":[190],"patient,":[191],"commenced":[194],"resulted":[196],"normalisation":[198],"CONCLUSION:":[203],"appear":[206],"transiently":[209],"D-IBS.":[212],"Future":[213],"work":[214],"assessing":[215],"may":[222],"potentially":[223],"identify":[224],"individuals":[225],"who":[226],"will":[227],"benefit":[228],"from":[229]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}