{"id":"https://openalex.org/W2415423908","doi":null,"title":"An agonist of liver X receptor slows valvular disease in a hypercholesterolemia mouse model.","display_name":"An agonist of liver X receptor slows valvular disease in a hypercholesterolemia mouse model.","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W2415423908","mag":"2415423908","pmid":"https://pubmed.ncbi.nlm.nih.gov/21053746"},"language":"en","primary_location":{"id":"pmid:21053746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21053746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart valve disease","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101574927","display_name":"Haimei Wang","orcid":"https://orcid.org/0000-0001-6317-9579","observed_orcids":["https://orcid.org/0000-0001-6317-9579"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4210141674","display_name":"Cedars-Sinai Smidt Heart Institute","ror":"https://ror.org/041vn2102","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haimei Wang","raw_affiliation_strings":["Division of Cardiothoracic Surgery, Department of Surgery, Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Davis Building Room 6014, Los Angeles, California 90048, USA. Haimei.Wang@hsc.utah.edu","Division of Cardiothoracic Surgery, Department of Surgery, Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Davis Building Room 6014, Los Angeles, California 90048, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery, Department of Surgery, Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Davis Building Room 6014, Los Angeles, California 90048, USA. Haimei.Wang@hsc.utah.edu","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]},{"raw_affiliation_string":"Division of Cardiothoracic Surgery, Department of Surgery, Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Davis Building Room 6014, Los Angeles, California 90048, USA","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004870643","display_name":"Sorel Goland","orcid":"https://orcid.org/0000-0002-5821-1113","observed_orcids":["https://orcid.org/0000-0002-5821-1113"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sorel Goland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kevin Burton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Burton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020746104","display_name":"Lawrence S.C. Czer","orcid":"https://orcid.org/0000-0001-5744-2625","observed_orcids":["https://orcid.org/0000-0001-5744-2625"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lawrence S C Czer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039501472","display_name":"Ernst R. Schwarz","orcid":"https://orcid.org/0000-0001-6999-3993","observed_orcids":["https://orcid.org/0000-0001-6999-3993"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ernst R Schwarz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5057486633","display_name":"Alfredo Trento","orcid":"https://orcid.org/0000-0002-9148-9416","observed_orcids":["https://orcid.org/0000-0002-9148-9416"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alfredo Trento","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4282,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.72184887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"5","first_page":"653","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.09220000356435776,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.03060000017285347,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-x-receptor-agonist","display_name":"liver X receptor agonist","score":0.9129999876022339},{"id":"https://openalex.org/keywords/valvular-calcification","display_name":"valve calcification","score":0.8140000104904175},{"id":"https://openalex.org/keywords/aortic-stenosis","display_name":"aortic stenosis","score":0.847000002861023},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8399999737739563},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cholesterol-efflux","display_name":"cholesterol efflux","score":0.7129999995231628},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.7760000228881836},{"id":"https://openalex.org/keywords/platelet-factor-4","display_name":"platelet factor 4","score":0.9520000219345093},{"id":"https://openalex.org/keywords/endothelial-cell-adhesion","display_name":"endothelial cell adhesion","score":0.7490000128746033},{"id":"https://openalex.org/keywords/bioprosthetic-valve-degeneration","display_name":"bioprosthetic valve degeneration","score":0.7789999842643738},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.4860000014305115},{"id":"https://openalex.org/keywords/calcium-deposition","display_name":"calcium deposition","score":0.5379999876022339},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7702692747116089},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7532215118408203},{"id":"https://openalex.org/C167400880","wikidata":"https://www.wikidata.org/wiki/Q3454539","display_name":"Liver X receptor","level":5,"score":0.7387531995773315},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7204049229621887},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6409078240394592},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.6099673509597778},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4984591007232666},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.49602755904197693},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.47801434993743896},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4592047333717346},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.41889238357543945},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.36980435252189636},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21077600121498108},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14359933137893677},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.13362666964530945},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071518","descriptor_name":"Liver X Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096926","descriptor_name":"Benzenesulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005466","descriptor_name":"Fluorocarbons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006349","descriptor_name":"Heart Valve Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006349","descriptor_name":"Heart Valve Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006349","descriptor_name":"Heart Valve Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006350","descriptor_name":"Heart Valve Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006845","descriptor_name":"Hydrocarbons, Fluorinated","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006845","descriptor_name":"Hydrocarbons, Fluorinated","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057093","descriptor_name":"Orphan Nuclear Receptors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21053746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21053746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart valve disease","raw_type":"Journal Article"},{"id":"mag:2415423908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21053746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W136660696","https://openalex.org/W200319174","https://openalex.org/W1531166004","https://openalex.org/W1538796336","https://openalex.org/W1974287326","https://openalex.org/W1974618259","https://openalex.org/W1979674730","https://openalex.org/W1980660426","https://openalex.org/W1986883175","https://openalex.org/W1991150986","https://openalex.org/W1992147175","https://openalex.org/W2003798182","https://openalex.org/W2003840075","https://openalex.org/W2011191553","https://openalex.org/W2018923286","https://openalex.org/W2024497915","https://openalex.org/W2025712487","https://openalex.org/W2026587556","https://openalex.org/W2034440990","https://openalex.org/W2043353709","https://openalex.org/W2047368989","https://openalex.org/W2049094974","https://openalex.org/W2049744618","https://openalex.org/W2053171963","https://openalex.org/W2053676669","https://openalex.org/W2056779230","https://openalex.org/W2061263330","https://openalex.org/W2063982755","https://openalex.org/W2082082688","https://openalex.org/W2085909854","https://openalex.org/W2090186331","https://openalex.org/W2093296161","https://openalex.org/W2093508343","https://openalex.org/W2107388688","https://openalex.org/W2108100915","https://openalex.org/W2112319867","https://openalex.org/W2113588089","https://openalex.org/W2117330772","https://openalex.org/W2127035878","https://openalex.org/W2130149021","https://openalex.org/W2131757351","https://openalex.org/W2138402059","https://openalex.org/W2144269821","https://openalex.org/W2153339824","https://openalex.org/W2153673003","https://openalex.org/W2154274736","https://openalex.org/W2159332620","https://openalex.org/W2164947674","https://openalex.org/W2167045683","https://openalex.org/W2324841714","https://openalex.org/W2408927170"],"related_works":["https://openalex.org/W7127618005","https://openalex.org/W2089528533","https://openalex.org/W2059526592","https://openalex.org/W2008947058","https://openalex.org/W4306255618","https://openalex.org/W4408474284","https://openalex.org/W4410488647","https://openalex.org/W2043805010","https://openalex.org/W175840670","https://openalex.org/W4366431712"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIM":[2],"OF":[3],"THE":[4],"STUDY:":[5],"Cholesterol":[6],"is":[7,24],"a":[8,25,54],"known":[9],"risk":[10],"factor":[11,163],"in":[12,45,86,103,150,206,227],"aortic":[13,46,88],"stenosis":[14],"and":[15,18,29,42,90,97,125,143,208,224,239,264],"valve":[16,62,137,266],"degeneration,":[17],"the":[19,70,111,116,159,199,204,241,259],"liver":[20],"X":[21],"receptor":[22],"(LXR)":[23],"regulator":[26],"of":[27,134,158,183,189,253],"cholesterol":[28,145,254],"phospholipid":[30],"metabolism.":[31],"It":[32],"was":[33],"hypothesized":[34],"that":[35,222,240,251],"an":[36],"LXR":[37,71,81,112,200],"agonist":[38,72,82,113,201],"would":[39],"reduce":[40,262],"calcium":[41,117,223],"lipid":[43,84,126,225,235],"deposition":[44,85,226],"valves.":[47],"METHODS:":[48],"Apolipoprotein":[49],"E-/-":[50],"(ApoE-/-)":[51],"mice":[52,152],"fed":[53],"high-fat":[55],"diet":[56],"were":[57,66,147,165],"implanted":[58],"with":[59,68,110,176],"glutaraldehyde-fixed":[60],"porcine":[61,136],"fragments.":[63],"The":[64,80,186,218],"animals":[65],"treated":[67,151,175],"either":[69],"T1317":[73],"or":[74],"vehicle":[75],"for":[76],"eight":[77],"weeks.":[78],"RESULTS:":[79],"reduced":[83,115,166],"native":[87,265],"roots":[89],"sinuses":[91],"about":[92],"two-fold":[93],"(p":[94,105,153],"<":[95,106,123,132,154],"0.05),":[96],"echocardiography":[98],"revealed":[99],"lower":[100,149],"transvalvular":[101],"velocities":[102],"vivo":[104],"0.05).":[107],"Similarly,":[108],"treatment":[109,188],"significantly":[114],"content":[118,127],"(by":[119,128],"ca.":[120,129],"50%,":[121],"p":[122,131],"0.05)":[124],"20%,":[130],"0.01)":[133],"explanted":[135],"tissue.":[138],"Serum":[139,156],"low-density":[140],"lipoprotein":[141],"(LDL)":[142],"total":[144],"levels":[146,157],"also":[148],"0.01).":[155],"inflammatory":[160,245],"chemokine":[161],"platelet":[162],"4":[164],"by":[167,215,233],"30%":[168],"compared":[169],"to":[170,195,261],"controls.":[171],"Cultured":[172],"valvular":[173,190],"cells":[174,192],"oxidized":[177],"LDL":[178],"(ox-LDL)":[179],"developed":[180],"greater":[181],"numbers":[182],"calcific":[184],"nodules.":[185],"ox-LDL":[187],"endothelial":[191],"increased":[193],"adhesion":[194,207,211],"mononuclear":[196],"cells,":[197],"while":[198],"reversed":[202],"both":[203],"increase":[205],"vascular":[209],"cell":[210,246],"protein-1":[212],"expression":[213],"mediated":[214],"ox-LDL.":[216],"CONCLUSION:":[217],"data":[219],"acquired":[220],"suggested":[221],"heart":[228],"valves":[229],"can":[230],"be":[231],"altered":[232],"inhibiting":[234],"metabolism":[236],"via":[237],"LXR,":[238],"mechanism":[242],"may":[243,257],"involve":[244],"signaling.":[247],"These":[248],"results":[249],"indicate":[250],"enhancement":[252],"efflux":[255],"activity":[256],"have":[258],"potential":[260],"bioprosthetic":[263],"degeneration.":[267]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}