{"id":"https://openalex.org/W2415359643","doi":null,"title":"[Changes of human immunophenotype during adaptation to environmental factors, in different forms of pathology and their specific treatment].","display_name":"[Changes of human immunophenotype during adaptation to environmental factors, in different forms of pathology and their specific treatment].","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2415359643","mag":"2415359643","pmid":"https://pubmed.ncbi.nlm.nih.gov/19143078"},"language":"ru","primary_location":{"id":"pmid:19143078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19143078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vestnik Rossiiskoi akademii meditsinskikh nauk","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042636637","display_name":"Litvitski\u012d Pf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P F Litvitski\u012d","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080038233","display_name":"Kukes Vg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V G Kukes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046064005","display_name":"Surnakova Ne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N E Surnakova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34316677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"11","first_page":"3","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.49390000104904175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.49390000104904175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.3190999925136566,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.06080000102519989,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunophenotype","display_name":"immunophenotype","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cd-molecules","display_name":"CD molecules","score":0.6669999957084656},{"id":"https://openalex.org/keywords/lymphocyte-apoptosis","display_name":"lymphocyte apoptosis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/immunoglobulins","display_name":"immunoglobulins","score":0.800000011920929},{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.9580000042915344},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rheumatic-fever","display_name":"rheumatic fever","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.3970000147819519},{"id":"https://openalex.org/keywords/environmental-adaptation","display_name":"environmental adaptation","score":0.6290000081062317},{"id":"https://openalex.org/keywords/specific-treatment","display_name":"specific therapy","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7203750014305115},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6655682921409607},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.5331503748893738},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5124743580818176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5029312968254089},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.48247388005256653},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4455655813217163},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3523138761520386},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3444180488586426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18744507431983948}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009031","descriptor_name":"Moscow","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014505","descriptor_name":"Urban Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018876","descriptor_name":"Environmental Illness","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018876","descriptor_name":"Environmental Illness","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D018876","descriptor_name":"Environmental Illness","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:19143078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19143078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vestnik Rossiiskoi akademii meditsinskikh nauk","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2733982940","https://openalex.org/W3031874996","https://openalex.org/W2078624362","https://openalex.org/W4246257048","https://openalex.org/W2023520746","https://openalex.org/W2790792342","https://openalex.org/W2528944312","https://openalex.org/W1990096101","https://openalex.org/W2414085062","https://openalex.org/W2093064338"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,11,18,24,27,35,37,71,78,86,91,98,132,141,151,185,191],"the":[3,16,58,84,128,136,164,183,200],"study":[4],"was":[5,153],"to":[6,20,182,188],"elucidate":[7],"mechanisms":[8],"underlying":[9],"variations":[10],"human":[12],"immune":[13,92,201],"phenotype":[14],"in":[15,40,49,57,106,118,127,139,156,163,169,194,199],"course":[17],"adaptation":[19],"environmental":[21],"factors,":[22],"development":[23],"different":[25,79],"forms":[26],"pathology":[28],"and":[29,43,68,74,88,93,113,124,149,160,175,196,202],"their":[30,72,144],"specific":[31,87,179],"treatment":[32,180],"from":[33],"dynamics":[34],"expression":[36,97,190],"surface":[38,133],"CD-molecules":[39],"lymphocyte":[41,66],"plasmolemma":[42],"immunoglobulin":[44],"A,":[45],"M,":[46],"G":[47],"levels":[48],"blood":[50],"plasma.":[51],"253":[52],"assumingly":[53],"healthy":[54],"volunteers":[55],"residing":[56],"Moscow":[59],"Megapolis":[60],"exhibited":[61],"a":[62],"tendency":[63],"toward":[64],"enhanced":[65,154],"apoptosis":[67,104],"reduced":[69],"efficiency":[70],"co-stimulation":[73],"cooperative":[75],"interaction.":[76],"Pathologies":[77],"etiology":[80],"were":[81],"associated":[82],"with":[83,109,120,158],"imbalance":[85],"non-specific":[89],"reactions":[90],"biological":[94,203],"control.":[95],"Specifically,":[96],"CD":[99,192],"95":[100],"(Fas/APO-1)":[101],"molecules":[102,193],"triggering":[103],"increased":[105],"all":[107],"patients":[108,119,157],"postmenopausal":[110,172],"osteoporosis,":[111,173],"pneumonia,":[112,174],"bronchial":[114,176],"asthma":[115],"but":[116],"decreased":[117,168],"rheumatic":[121,170],"fever,":[122,171],"erosive":[123,159],"ulcerative":[125,161],"lesions":[126,162],"digestive":[129,165],"tract.":[130,166],"Expression":[131],"receptors":[134],"by":[135,146],"cells":[137],"involved":[138],"\"processing\"":[140],"unshared":[142],"antigens,":[143],"presentation":[145],"T-lymphocytes,":[147],"inactivation":[148],"destruction":[150],"pathogens":[152],"only":[155],"It":[167],"asthma.":[177],"Effective":[178],"leading":[181],"normalization":[184],"(or":[186],"tending":[187],"normalize)":[189],"lymphocytes":[195],"prevented":[197],"changes":[198],"control":[204],"system.":[205]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}