{"id":"https://openalex.org/W2415358491","doi":null,"title":"Interferon production by human leukaemic leucocytes.","display_name":"Interferon production by human leukaemic leucocytes.","publication_year":1976,"publication_date":"1976-01-01","ids":{"openalex":"https://openalex.org/W2415358491","mag":"2415358491","pmid":"https://pubmed.ncbi.nlm.nih.gov/180756"},"language":"en","primary_location":{"id":"pmid:180756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/180756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta microbiologica Academiae Scientiarum Hungaricae","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090153146","display_name":"Gy. Hadhazy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Hadh\u00e1zy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109879147","display_name":"B\u00e9la Fekete","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Fekete","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006482005","display_name":"Gy\u00f6ngyi Szab\u00f3","orcid":"https://orcid.org/0000-0003-0836-2527","observed_orcids":["https://orcid.org/0000-0003-0836-2527"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Szab\u00f3","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019565160","display_name":"B. Szab\u00f3","orcid":"https://orcid.org/0000-0002-0097-9867","observed_orcids":["https://orcid.org/0000-0002-0097-9867"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Szab\u00f3","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"1","first_page":"15","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-production","display_name":"interferon production","score":0.9359999895095825},{"id":"https://openalex.org/keywords/sendai-virus","display_name":"Sendai virus","score":0.9359999895095825},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.906000018119812},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cytostatic-drugs","display_name":"cytostatic agents","score":0.7049999833106995},{"id":"https://openalex.org/keywords/dactinomycin","display_name":"actinomycin D","score":0.8420000076293945},{"id":"https://openalex.org/keywords/puromycin","display_name":"puromycin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.5619999766349792},{"id":"https://openalex.org/keywords/rna-synthesis","display_name":"RNA synthesis","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C2780127873","wikidata":"https://www.wikidata.org/wiki/Q1055751","display_name":"Sendai virus","level":3,"score":0.8024181723594666},{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.7057892084121704},{"id":"https://openalex.org/C2779200571","wikidata":"https://www.wikidata.org/wiki/Q424696","display_name":"Puromycin","level":3,"score":0.5577324032783508},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5359232425689697},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5291284322738647},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4569568634033203},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.45495808124542236},{"id":"https://openalex.org/C113842279","wikidata":"https://www.wikidata.org/wiki/Q1873857","display_name":"Lymphoblast","level":3,"score":0.4508294463157654},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.44245511293411255},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4347776770591736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43337810039520264},{"id":"https://openalex.org/C2776695378","wikidata":"https://www.wikidata.org/wiki/Q186127","display_name":"Dactinomycin","level":4,"score":0.4143153429031372},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3756333291530609},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36407822370529175},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.35550957918167114},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.31270670890808105},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.22225621342658997},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20668068528175354},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.18061548471450806},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08078056573867798},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007945","descriptor_name":"Leukemia, Lymphoid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010222","descriptor_name":"Parainfluenza Virus 1, Human","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D011691","descriptor_name":"Puromycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:180756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/180756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta microbiologica Academiae Scientiarum Hungaricae","raw_type":"Comparative Study"},{"id":"mag:2415358491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/180756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1587411264","https://openalex.org/W2330592282","https://openalex.org/W1988349837","https://openalex.org/W2235171644","https://openalex.org/W2002855129","https://openalex.org/W1816241600","https://openalex.org/W2007401819","https://openalex.org/W2065529056","https://openalex.org/W2295068276","https://openalex.org/W152296963"],"abstract_inverted_index":{"The":[0],"Sendai":[1,159],"virus-induced":[2,160],"interferon":[3],"(IF)":[4],"production":[5,27,45,56,83],"by":[6,60,89],"partially":[7],"purified":[8],"human":[9],"leucocyte":[10],"suspensions":[11],"of":[12,16,63,72,91,109,152],"normal":[13,48,74,114,139],"donors":[14],"and":[15,124],"leukaemic":[17],"patients":[18,34],"have":[19],"been":[20],"investigated":[21],"in":[22,86,136,145,149,163],"vitro.":[23],"(i)":[24],"An":[25],"increased":[26],"was":[28,46,57,84],"observed":[29],"with":[30,49,120,128],"leucocytes":[31,77,102,165],"taken":[32,51],"from":[33,36,118,126],"suffering":[35],"chronic":[37,129],"myelogenous":[38],"leukaemia":[39,123,134],"(CML)":[40],"during":[41,52],"exacerbation,":[42],"but":[43],"the":[44,146,150,158],"approximately":[47,141],"cells":[50],"remission.":[53],"(ii)":[54],"IF":[55,104,144,161],"not":[58],"influenced":[59],"large":[61],"doses":[62],"cytostatics":[64],"(DBM,":[65],"5-FU,":[66],"FUDR,":[67],"5-HU,":[68],"6-MP,":[69],"cyclophosphamide)":[70],"irrespective":[71],"whether":[73],"or":[75,93,131],"CML":[76,101,164],"were":[78],"used.":[79],"(iii)":[80],"In":[81],"contrast,":[82],"inhibited":[85],"both":[87],"systems":[88],"inhibitors":[90],"RNA":[92],"protein":[94,169],"synthesis":[95,162],"(actinomycin":[96],"D,":[97],"puromycin,":[98],"cycloheximide).":[99],"(iv)":[100],"produced":[103],"for":[105],"a":[106],"prolonged":[107],"period":[108],"time":[110],"as":[111,142,148],"compared":[112],"to":[113,138],"leucocytes.":[115],"(v)":[116],"Leucocytes":[117],"children":[119],"acute":[121,132],"blastic":[122],"those":[125],"adults":[127],"lymphoid":[130],"paramyeloblastic":[133],"produce,":[135],"contrast":[137],"leukocytes,":[140],"much":[143],"absence":[147],"presence":[151],"serum.":[153],"It":[154],"is":[155],"concluded":[156],"that":[157],"requires":[166],"de":[167],"novo":[168],"synthesis.":[170]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
