{"id":"https://openalex.org/W2415340552","doi":"https://doi.org/10.1007/s10875-016-0303-4","title":"Flebogamma\u00ae 5 % DIF Intravenous Immunoglobulin for Replacement Therapy in Children with Primary Immunodeficiency Diseases","display_name":"Flebogamma\u00ae 5 % DIF Intravenous Immunoglobulin for Replacement Therapy in Children with Primary Immunodeficiency Diseases","publication_year":2016,"publication_date":"2016-06-08","ids":{"openalex":"https://openalex.org/W2415340552","doi":"https://doi.org/10.1007/s10875-016-0303-4","mag":"2415340552","pmid":"https://pubmed.ncbi.nlm.nih.gov/27279130"},"language":"en","primary_location":{"id":"doi:10.1007/s10875-016-0303-4","doi":"https://doi.org/10.1007/s10875-016-0303-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10875-016-0303-4","pdf_url":null,"source":{"id":"https://openalex.org/S57504206","display_name":"Journal of Clinical Immunology","issn_l":"0271-9142","issn":["0271-9142","1573-2592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037734477","display_name":"Mark C. Ballow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289499695","display_name":"Women & Children's Hospital of Buffalo","ror":"https://ror.org/00kg66g91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289499695"]},{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I75821886","display_name":"University of South Florida St. Petersburg","ror":"https://ror.org/016gp6x28","country_code":"US","type":"education","lineage":["https://openalex.org/I75821886"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark Ballow","raw_affiliation_strings":["Division of Allergy and Immunology, Department of Pediatrics, University of South Florida, 601 4th Street South, Saint Petersburg, FL, 3370, USA. markbal.aird@gmail.com","The Children's Hospital of Buffalo, Buffalo, NY, USA. markbal.aird@gmail.com","The Children\u2019s Hospital of Buffalo, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy and Immunology, Department of Pediatrics, University of South Florida, 601 4th Street South, Saint Petersburg, FL, 3370, USA. markbal.aird@gmail.com","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I75821886"]},{"raw_affiliation_string":"The Children's Hospital of Buffalo, Buffalo, NY, USA. markbal.aird@gmail.com","institution_ids":["https://openalex.org/I1289499695"]},{"raw_affiliation_string":"The Children\u2019s Hospital of Buffalo, Buffalo, NY, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085185353","display_name":"Paul J. Pinciaro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157443","display_name":"Grifols (United States)","ror":"https://ror.org/05fvbww60","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126725","https://openalex.org/I4210157443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J. Pinciaro","raw_affiliation_strings":["Grifols Biologicals Inc., Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grifols Biologicals Inc., Los Angeles, CA, USA","institution_ids":["https://openalex.org/I4210157443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111343464","display_name":"Timothy Craig","orcid":"https://orcid.org/0000-0002-7774-4855","observed_orcids":["https://orcid.org/0000-0002-7774-4855"]},"institutions":[{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Craig","raw_affiliation_strings":["Penn State University Hershey Medical Center, Hershey, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Penn State University Hershey Medical Center, Hershey, PA, USA","institution_ids":["https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057831353","display_name":"Gary Kleiner","orcid":"https://orcid.org/0000-0003-2066-9476","observed_orcids":["https://orcid.org/0000-0003-2066-9476"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Kleiner","raw_affiliation_strings":["Jeffrey Modell Diagnostic Center for Primary Immunodeficiencies, University of Miami, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jeffrey Modell Diagnostic Center for Primary Immunodeficiencies, University of Miami, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046607428","display_name":"James N. Moy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Moy","raw_affiliation_strings":["Allergy and Immunology, Rush University Medical Center, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergy and Immunology, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062237763","display_name":"Hans D. Ochs","orcid":"https://orcid.org/0000-0002-7726-3218","observed_orcids":["https://orcid.org/0000-0002-7726-3218"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans D. Ochs","raw_affiliation_strings":["Seattle Children's Research Institute and University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Children's Research Institute and University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064611705","display_name":"John W. Sleasman","orcid":"https://orcid.org/0000-0003-0078-5867","observed_orcids":["https://orcid.org/0000-0003-0078-5867"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I75821886","display_name":"University of South Florida St. Petersburg","ror":"https://ror.org/016gp6x28","country_code":"US","type":"education","lineage":["https://openalex.org/I75821886"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Sleasman","raw_affiliation_strings":["Division of Allergy and Immunology, Department of Pediatrics, University of South Florida, 601 4th Street South, Saint Petersburg, FL, 3370, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy and Immunology, Department of Pediatrics, University of South Florida, 601 4th Street South, Saint Petersburg, FL, 3370, USA","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I75821886"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054769803","display_name":"William L. Smits","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Smits","raw_affiliation_strings":["The Allergy and Asthma Center, Fort Wayne, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Allergy and Asthma Center, Fort Wayne, IN, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5037734477"],"corresponding_institution_ids":["https://openalex.org/I1289499695","https://openalex.org/I2613432","https://openalex.org/I75821886"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":0.4037,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.68125899,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"36","issue":"6","first_page":"583","last_page":"589"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/primary-immunodeficiency","display_name":"primary immunodeficiency","score":0.9419999718666077},{"id":"https://openalex.org/keywords/pediatric-immunodeficiency","display_name":"pediatric immunodeficiency","score":0.6610000133514404},{"id":"https://openalex.org/keywords/replacement-therapy","display_name":"replacement therapy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8790000081062317},{"id":"https://openalex.org/keywords/serious-bacterial-infection","display_name":"serious bacterial infection","score":0.7350000143051147},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8949999809265137},{"id":"https://openalex.org/keywords/immunoglobulin-deficiency","display_name":"antibody deficiency","score":0.8370000123977661},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.860811710357666},{"id":"https://openalex.org/C2779019163","wikidata":"https://www.wikidata.org/wiki/Q3043160","display_name":"Primary immunodeficiency","level":3,"score":0.8373674154281616},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.680147111415863},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5686748027801514},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5464174151420593},{"id":"https://openalex.org/C2776433325","wikidata":"https://www.wikidata.org/wiki/Q1472818","display_name":"Common variable immunodeficiency","level":3,"score":0.5136424899101257},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5092002749443054},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5002975463867188},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.44346508383750916},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4392739534378052},{"id":"https://openalex.org/C31785415","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough level","level":4,"score":0.4335514307022095},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43145808577537537},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.4245795011520386},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42418861389160156},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.421236515045166},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.15565291047096252},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.13941490650177002},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.0},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016756","descriptor_name":"Immunoglobulins, Intravenous","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016756","descriptor_name":"Immunoglobulins, Intravenous","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016756","descriptor_name":"Immunoglobulins, Intravenous","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10875-016-0303-4","doi":"https://doi.org/10.1007/s10875-016-0303-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10875-016-0303-4","pdf_url":null,"source":{"id":"https://openalex.org/S57504206","display_name":"Journal of Clinical Immunology","issn_l":"0271-9142","issn":["0271-9142","1573-2592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:27279130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27279130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical immunology","raw_type":"Clinical Trial, Phase IV"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.41999998688697815}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310420","display_name":"CSL Behring","ror":"https://ror.org/01jxhxv92"},{"id":"https://openalex.org/F4320311257","display_name":"Baxalta","ror":"https://ror.org/040fqas51"},{"id":"https://openalex.org/F4320315426","display_name":"BioCryst","ror":"https://ror.org/031mgj447"},{"id":"https://openalex.org/F4320329568","display_name":"Grifols","ror":"https://ror.org/02ed64f32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W62151259","https://openalex.org/W1548115640","https://openalex.org/W1563690785","https://openalex.org/W1620638653","https://openalex.org/W1975546450","https://openalex.org/W1975826359","https://openalex.org/W1981376889","https://openalex.org/W1992896344","https://openalex.org/W2006890544","https://openalex.org/W2009196215","https://openalex.org/W2018036110","https://openalex.org/W2018530537","https://openalex.org/W2021238422","https://openalex.org/W2024981893","https://openalex.org/W2031590884","https://openalex.org/W2068658818","https://openalex.org/W2070498696","https://openalex.org/W2075175074","https://openalex.org/W2100711023","https://openalex.org/W2104382376","https://openalex.org/W2117403402","https://openalex.org/W2124825720","https://openalex.org/W2131200545","https://openalex.org/W2145821782","https://openalex.org/W2151929844","https://openalex.org/W2158904722","https://openalex.org/W2160641274","https://openalex.org/W2168005605","https://openalex.org/W2288605373","https://openalex.org/W2544036876"],"related_works":["https://openalex.org/W2067725196","https://openalex.org/W2018530537","https://openalex.org/W2068658818","https://openalex.org/W2070498696","https://openalex.org/W2886884946","https://openalex.org/W4412100181","https://openalex.org/W3086590988","https://openalex.org/W2751816687","https://openalex.org/W2205267085","https://openalex.org/W1590526528"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}