{"id":"https://openalex.org/W2415338646","doi":"https://doi.org/10.22029/eir.2005.1617","title":"CDNA-microarray analysis as a research tool for expression profiling in human peripheral blood following exercise","display_name":"CDNA-microarray analysis as a research tool for expression profiling in human peripheral blood following exercise","publication_year":2026,"publication_date":"2026-07-15","ids":{"openalex":"https://openalex.org/W2415338646","doi":"https://doi.org/10.22029/eir.2005.1617","mag":"2415338646","pmid":"https://pubmed.ncbi.nlm.nih.gov/16385846"},"language":"en","primary_location":{"id":"pmid:16385846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16385846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exercise immunology review","raw_type":"Evaluation Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.22029/eir.2005.1617","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034312656","display_name":"Derek Zieker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Zieker, D","raw_affiliation_strings":["Institute of clinical and experimental Transfusion Medicine, University of Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of clinical and experimental Transfusion Medicine, University of Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014752869","display_name":"Judith Zieker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zieker, J","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011153238","display_name":"Janko Dietzsch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dietzsch, J","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037175873","display_name":"Michael W. M. Burnet","orcid":"https://orcid.org/0000-0003-4311-5441","observed_orcids":["https://orcid.org/0000-0003-4311-5441"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Burnet, M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108531625","display_name":"Hinnak Northoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Northoff, H","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076971747","display_name":"Elvira Fehrenbach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fehrenbach, E","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4838,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.84436106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":null,"first_page":"86","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endurance-exercise","display_name":"endurance exercise","score":0.8140000104904175},{"id":"https://openalex.org/keywords/half-marathon","display_name":"half marathon","score":0.6150000095367432},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7149999737739563},{"id":"https://openalex.org/keywords/peripheral-blood-leukocytes","display_name":"peripheral blood leukocytes","score":0.7889999747276306},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/exercise-immunology","display_name":"exercise immunology","score":0.5730000138282776},{"id":"https://openalex.org/keywords/exhaustive-exercise","display_name":"exhaustive exercise","score":0.5640000104904175},{"id":"https://openalex.org/keywords/exercise-related-injuries","display_name":"exercise-related injuries","score":0.8190000057220459},{"id":"https://openalex.org/keywords/exercise-stress","display_name":"exercise stress","score":0.6309999823570251},{"id":"https://openalex.org/keywords/rule-based-clustering","display_name":"rule-based clustering","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.6714114546775818},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.6587744951248169},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.612784743309021},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5864242911338806},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.556592583656311},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5247247815132141},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.46074047684669495},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4595015048980713},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.4521404504776001},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40843620896339417},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40707144141197205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3871263265609741},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36431294679641724},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24817883968353271},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23805251717567444}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012420","descriptor_name":"Running","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016172","descriptor_name":"DNA Fingerprinting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:16385846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16385846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exercise immunology review","raw_type":"Evaluation Study"},{"id":"doi:10.22029/eir.2005.1617","doi":"https://doi.org/10.22029/eir.2005.1617","is_oa":true,"landing_page_url":"https://doi.org/10.22029/eir.2005.1617","pdf_url":null,"source":{"id":"https://openalex.org/S7407052994","display_name":"Universit\u00e4tsbibliothek Gie\u00dfen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200763008","host_organization_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","host_organization_lineage":["https://openalex.org/I200763008"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"mag:2415338646","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16385846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.22029/eir.2005.1617","doi":"https://doi.org/10.22029/eir.2005.1617","is_oa":true,"landing_page_url":"https://doi.org/10.22029/eir.2005.1617","pdf_url":null,"source":{"id":"https://openalex.org/S7407052994","display_name":"Universit\u00e4tsbibliothek Gie\u00dfen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200763008","host_organization_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","host_organization_lineage":["https://openalex.org/I200763008"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W12690937","https://openalex.org/W1521206682","https://openalex.org/W1530241823","https://openalex.org/W1591103902","https://openalex.org/W1966683993","https://openalex.org/W1970156673","https://openalex.org/W1978158181","https://openalex.org/W1989297334","https://openalex.org/W2005961804","https://openalex.org/W2043324873","https://openalex.org/W2047513783","https://openalex.org/W2065183358","https://openalex.org/W2070063270","https://openalex.org/W2073564445","https://openalex.org/W2101197345","https://openalex.org/W2109141141","https://openalex.org/W2110385921","https://openalex.org/W2114034523","https://openalex.org/W2121777852","https://openalex.org/W2133425690","https://openalex.org/W2135187880","https://openalex.org/W2145572948","https://openalex.org/W2148114338","https://openalex.org/W2150926065","https://openalex.org/W2160697532","https://openalex.org/W2172013173","https://openalex.org/W2172133801","https://openalex.org/W2418081768"],"related_works":["https://openalex.org/W2017047508","https://openalex.org/W2109141141","https://openalex.org/W164891082","https://openalex.org/W2095145605","https://openalex.org/W2010488099","https://openalex.org/W1951909072","https://openalex.org/W7096704648","https://openalex.org/W2135881953","https://openalex.org/W4242692719","https://openalex.org/W1973649674"],"abstract_inverted_index":{"Exhausting":[0],"endurance":[1],"exercise":[2,59,179],"has":[3],"strong":[4],"effects":[5],"on":[6,35],"the":[7,15,108,146,150],"immune":[8],"system.":[9],"Changes":[10],"have":[11],"been":[12],"shown":[13],"in":[14,22,71,102,126],"cellular":[16],"composition":[17],"of":[18,100,110,145,149,178],"peripheral":[19],"blood":[20,43],"and":[21,55,87,92,134,176,182],"gene":[23,41,74,160],"expression":[24,42,75,120,161],"within":[25],"those":[26],"cells.":[27],"In":[28],"this":[29],"study,":[30],"custom-made":[31],"cDNA":[32],"microarrays":[33,62],"focused":[34],"inflammation":[36],"were":[37,64],"used":[38,65],"to":[39,128,152,170],"analyze":[40],"cells":[44],"obtained":[45],"from":[46],"eight":[47,104],"half-marathon":[48],"runners":[49],"before":[50],"(t0),":[51],"immediately":[52],"after":[53,58],"(t1)":[54],"24":[56],"hours":[57],"(t2).":[60],"The":[61,132],"that":[63,159],"contained":[66],"384":[67],"different":[68],"cDNAs":[69],"spotted":[70],"triplicate.":[72],"Differentially-regulated":[73],"was":[76],"analyzed":[77],"using":[78],"a":[79,97,118,129,166],"simple":[80],"rule-based":[81],"clustering.":[82],"Comparing":[83],"t1":[84],"vs.":[85,89],"t0,":[86,90],"t2":[88],"36":[91],"21":[93],"sequences":[94],"respectively,":[95],"showed":[96],"consistent":[98],"pattern":[99,109],"changes":[101],"all":[103],"athletes.":[105],"Taken":[106],"together,":[107],"these":[111],"modified":[112],"genes":[113,136],"can":[114,163],"be":[115],"viewed":[116],"as":[117,165],"\"gene":[119],"fingerprint\"":[121],"for":[122,141,174],"each":[123],"time":[124],"point":[125],"response":[127],"half":[130],"marathon.":[131],"known":[133],"novel":[135,172],"identified":[137],"here":[138],"represent":[139],"targets":[140],"further":[142],"molecular":[143],"characterization":[144],"complex":[147],"reaction":[148],"body":[151],"an":[153],"exhaustive":[154],"challenge.":[155],"These":[156],"data":[157],"suggest":[158],"fingerprints":[162],"serve":[164],"powerful":[167],"research":[168],"tool":[169],"design":[171],"strategies":[173],"diagnosis":[175],"treatment":[177],"related":[180],"injury":[181],"stress.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}