{"id":"https://openalex.org/W2415299397","doi":null,"title":"Subtypes of Triple-negative Breast Cancer Cell Lines React Differently to Eribulin Mesylate.","display_name":"Subtypes of Triple-negative Breast Cancer Cell Lines React Differently to Eribulin Mesylate.","publication_year":2016,"publication_date":"2016-06-01","ids":{"openalex":"https://openalex.org/W2415299397","mag":"2415299397","pmid":"https://pubmed.ncbi.nlm.nih.gov/27272786"},"language":"en","primary_location":{"id":"pmid:27272786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27272786","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046309596","display_name":"Karen Br\u00e4utigam","orcid":"https://orcid.org/0000-0001-8521-9607","observed_orcids":["https://orcid.org/0000-0001-8521-9607"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karen Br\u00e4utigam","raw_affiliation_strings":["Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany Karen.Braeutigam@uksh.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany Karen.Braeutigam@uksh.de","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007396642","display_name":"Katharina Mitzlaff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina Mitzlaff","raw_affiliation_strings":["Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109267333","display_name":"Lisa Uebel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lisa Uebel","raw_affiliation_strings":["Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073402824","display_name":"Frank K\u00f6ster","orcid":"https://orcid.org/0000-0001-8684-3698","observed_orcids":["https://orcid.org/0000-0001-8684-3698"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank K\u00f6ster","raw_affiliation_strings":["Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073331751","display_name":"Stephan Polack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephan Polack","raw_affiliation_strings":["Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025591044","display_name":"Mascha Pervan","orcid":"https://orcid.org/0000-0003-0780-6245","observed_orcids":["https://orcid.org/0000-0003-0780-6245"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mascha Pervan","raw_affiliation_strings":["Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070683908","display_name":"Gunnar Steinert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108319","display_name":"Eisai (Germany)","ror":"https://ror.org/01t10vs30","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210108319","https://openalex.org/I55881946"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gunnar Steinert","raw_affiliation_strings":["Eisai GmbH, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai GmbH, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210108319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038243095","display_name":"Achim Rody","orcid":"https://orcid.org/0000-0001-5904-0486","observed_orcids":["https://orcid.org/0000-0001-5904-0486"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Achim Rody","raw_affiliation_strings":["Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110897702","display_name":"Cornelia Liedtke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cornelia Liedtke","raw_affiliation_strings":["Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3438,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.57215367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"36","issue":"6","first_page":"2759","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.4302000105381012,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":1.0},{"id":"https://openalex.org/keywords/eribulin-mesylate","display_name":"eribulin mesylate","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tnbc-subtypes","display_name":"TNBC subtypes","score":0.8510000109672546},{"id":"https://openalex.org/keywords/breast-cancer-cell-lines","display_name":"breast cancer cell lines","score":0.8289999961853027},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.8700000047683716},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.828000009059906},{"id":"https://openalex.org/keywords/gene-expression-changes","display_name":"gene expression changes","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2776387010","wikidata":"https://www.wikidata.org/wiki/Q408717","display_name":"Eribulin","level":5,"score":0.9847267866134644},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.8100206851959229},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.644668459892273},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6065091490745544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46709057688713074},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.45741623640060425},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4467124938964844},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44420522451400757},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39297547936439514},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3736090660095215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35437196493148804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3379138708114624},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.31275051832199097},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.04269525408744812}],"mesh":[{"descriptor_ui":"D000095662","descriptor_name":"Polyether Polyketides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007659","descriptor_name":"Ketones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050256","descriptor_name":"Antimitotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:27272786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27272786","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2415299397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27272786","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1977507384","https://openalex.org/W2097255042","https://openalex.org/W2102838762","https://openalex.org/W2127152525","https://openalex.org/W2134539328","https://openalex.org/W2138474420","https://openalex.org/W2138941973","https://openalex.org/W2154899482","https://openalex.org/W2164930765"],"related_works":["https://openalex.org/W2402920927","https://openalex.org/W2342792429","https://openalex.org/W2030328153","https://openalex.org/W3083221672","https://openalex.org/W2963023921","https://openalex.org/W2290033819","https://openalex.org/W2801082038","https://openalex.org/W1542412204","https://openalex.org/W2982352864","https://openalex.org/W7128585988"],"abstract_inverted_index":{"BACKGROUND/AIM:":[0],"Diagnosis":[1],"of":[2,15,20,33,98],"triple-negative":[3],"breast":[4,122],"cancer":[5,49,123],"(TNBC)":[6],"is":[7],"associated":[8],"with":[9,37,140],"adverse":[10],"prognosis,":[11],"particularly":[12],"in":[13,43,78,84],"cases":[14],"chemotherapy":[16],"resistance.":[17],"The":[18],"goal":[19],"this":[21],"analysis":[22],"was":[23],"to":[24,39,41,54,71,90,104,142,144],"compare":[25],"TNBC":[26,35,79,135],"vs.":[27],"non-TNBC":[28,81,137],"cell":[29,50,76,82,124,138],"lines":[30,51,83,139],"and":[31,60,63,80,94,100,136],"those":[32],"distinct":[34],"subtypes":[36],"regard":[38,141],"sensitivity":[40,143],"eribulin":[42,91,112],"vitro.":[44],"MATERIALS":[45],"AND":[46],"METHODS:":[47],"Breast":[48],"were":[52,108],"subjected":[53],"cell-viability":[55],"assays,":[56],"apoptosis":[57,93],"analyses,":[58],"migration":[59,99],"invasion":[61],"experiments,":[62],"quantitative":[64],"real-time":[65],"polymerase":[66],"chain":[67],"reaction":[68],"after":[69,111],"exposure":[70,89],"eribulin.":[72,145],"RESULTS:":[73],"Eribulin":[74,115],"reduced":[75],"viability":[77],"the":[85,96],"sub-nanomolar":[86],"range.":[87],"Furthermore,":[88],"induced":[92],"decreased":[95],"rate":[97],"invasion.":[101],"Genes":[102],"known":[103],"induce":[105],"malignant":[106],"transformation":[107],"differentially":[109],"expressed":[110],"treatment.":[113],"CONCLUSION:":[114],"had":[116],"a":[117,131],"strong":[118],"antiproliferative":[119],"effect":[120],"on":[121],"lines,":[125],"although":[126],"we":[127],"did":[128],"not":[129],"observe":[130],"significant":[132],"difference":[133],"between":[134]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}