{"id":"https://openalex.org/W2415243990","doi":null,"title":"Modulation of nicotinic acetylcholine receptor function through the outer and middle rings of transmembrane domains.","display_name":"Modulation of nicotinic acetylcholine receptor function through the outer and middle rings of transmembrane domains.","publication_year":2003,"publication_date":"2003-09-01","ids":{"openalex":"https://openalex.org/W2415243990","mag":"2415243990","pmid":"https://pubmed.ncbi.nlm.nih.gov/14579511"},"language":"en","primary_location":{"id":"pmid:14579511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14579511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in drug discovery & development","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006767226","display_name":"Francisco Jos\u00e9 Barrantes","orcid":"https://orcid.org/0000-0002-4745-681X","observed_orcids":["https://orcid.org/0000-0002-4745-681X"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I56858762","display_name":"Universidad Nacional del Sur","ror":"https://ror.org/028crwz56","country_code":"AR","type":"education","lineage":["https://openalex.org/I56858762"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Francisco J Barrantes","raw_affiliation_strings":["Instituto de Investigaciones Bioqu\u00edmicas, Universidad Nacional del Sur-CONICET CC 857, F8000FWB Bah\u00eda Blanca, Argentina. rtfjb1@criba.edu.ar","Instituto de Investigaciones Bioqu\u00edmicas, Universidad Nacional del Sur-CONICET CC 857, F8000FWB Bah\u00eda Blanca, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Bioqu\u00edmicas, Universidad Nacional del Sur-CONICET CC 857, F8000FWB Bah\u00eda Blanca, Argentina. rtfjb1@criba.edu.ar","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I56858762"]},{"raw_affiliation_string":"Instituto de Investigaciones Bioqu\u00edmicas, Universidad Nacional del Sur-CONICET CC 857, F8000FWB Bah\u00eda Blanca, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I56858762"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006767226"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I56858762"],"apc_list":null,"apc_paid":null,"fwci":1.414,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.78355799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"6","issue":"5","first_page":"620","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":1.0},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.925000011920929},{"id":"https://openalex.org/keywords/lipid-bilayers","display_name":"lipid bilayers","score":0.5329999923706055},{"id":"https://openalex.org/keywords/m2-segment","display_name":"M2 segment","score":0.5059999823570251},{"id":"https://openalex.org/keywords/outer-ring","display_name":"outer ring","score":0.5270000100135803},{"id":"https://openalex.org/keywords/channel-gating","display_name":"channel gating","score":0.7089999914169312},{"id":"https://openalex.org/keywords/sterols","display_name":"sterols","score":0.5619999766349792},{"id":"https://openalex.org/keywords/steroids","display_name":"steroids","score":0.9829999804496765},{"id":"https://openalex.org/keywords/photoaffinity-labeling","display_name":"photoaffinity labeling","score":0.7739999890327454},{"id":"https://openalex.org/keywords/ion-channels","display_name":"ion channels","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.667557954788208},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.6592849493026733},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6523662209510803},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6407425403594971},{"id":"https://openalex.org/C2779570518","wikidata":"https://www.wikidata.org/wiki/Q412256","display_name":"Nicotinic acetylcholine receptor","level":4,"score":0.6379967331886292},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.5739454627037048},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.5709164142608643},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.5664888620376587},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.5178706645965576},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.510155975818634},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4413433372974396},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.42690199613571167},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3405950665473938},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2697317600250244},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.24134355783462524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15547028183937073},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000438","descriptor_name":"Alcohols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:14579511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14579511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in drug discovery & development","raw_type":"Journal Article"},{"id":"mag:2415243990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14579511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G247778828","display_name":"ROLE OF PROTEIN-LIPID INTERACTIONS IN ACHR GATING","funder_award_id":"R03TW001225","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"}],"funders":[{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W193076579","https://openalex.org/W1137855635","https://openalex.org/W1429190862","https://openalex.org/W1492943506","https://openalex.org/W1505990424","https://openalex.org/W1560215073","https://openalex.org/W1564990428","https://openalex.org/W1568140757","https://openalex.org/W1788430178","https://openalex.org/W1860217984","https://openalex.org/W1938746192","https://openalex.org/W1964490459","https://openalex.org/W1967602174","https://openalex.org/W1968686556","https://openalex.org/W1972134290","https://openalex.org/W1973217630","https://openalex.org/W1974539026","https://openalex.org/W1975938820","https://openalex.org/W1983087241","https://openalex.org/W1983329775","https://openalex.org/W1987247771","https://openalex.org/W1994132490","https://openalex.org/W1994215475","https://openalex.org/W1994522080","https://openalex.org/W1997581980","https://openalex.org/W2000594997","https://openalex.org/W2001853114","https://openalex.org/W2003978459","https://openalex.org/W2005843451","https://openalex.org/W2006993514","https://openalex.org/W2008392096","https://openalex.org/W2009155017","https://openalex.org/W2010341122","https://openalex.org/W2010379824","https://openalex.org/W2012140645","https://openalex.org/W2016007892","https://openalex.org/W2016171664","https://openalex.org/W2019282783","https://openalex.org/W2023125175","https://openalex.org/W2024226919","https://openalex.org/W2027093946","https://openalex.org/W2027535192","https://openalex.org/W2027687831","https://openalex.org/W2028272452","https://openalex.org/W2028677052","https://openalex.org/W2029032935","https://openalex.org/W2030888952","https://openalex.org/W2032079484","https://openalex.org/W2033159509","https://openalex.org/W2037138534","https://openalex.org/W2037581978","https://openalex.org/W2038768143","https://openalex.org/W2041315577","https://openalex.org/W2046200953","https://openalex.org/W2046544750","https://openalex.org/W2046587077","https://openalex.org/W2047844288","https://openalex.org/W2049133285","https://openalex.org/W2049848440","https://openalex.org/W2053386876","https://openalex.org/W2056778461","https://openalex.org/W2058681817","https://openalex.org/W2061330809","https://openalex.org/W2064458965","https://openalex.org/W2067850241","https://openalex.org/W2069519194","https://openalex.org/W2070986555","https://openalex.org/W2071948808","https://openalex.org/W2074005920","https://openalex.org/W2074445983","https://openalex.org/W2074785483","https://openalex.org/W2075798487","https://openalex.org/W2081272072","https://openalex.org/W2081307064","https://openalex.org/W2082260848","https://openalex.org/W2082283206","https://openalex.org/W2084542172","https://openalex.org/W2086833427","https://openalex.org/W2088927603","https://openalex.org/W2100323088","https://openalex.org/W2101983215","https://openalex.org/W2103800908","https://openalex.org/W2105069140","https://openalex.org/W2107106792","https://openalex.org/W2112897543","https://openalex.org/W2113217079","https://openalex.org/W2113310829","https://openalex.org/W2113789606","https://openalex.org/W2116026746","https://openalex.org/W2117429193","https://openalex.org/W2119870811","https://openalex.org/W2130529910","https://openalex.org/W2134516970","https://openalex.org/W2138064823","https://openalex.org/W2139205520","https://openalex.org/W2147119931","https://openalex.org/W2156839406","https://openalex.org/W2158864829","https://openalex.org/W2163911664","https://openalex.org/W2168214772","https://openalex.org/W2310730705","https://openalex.org/W2411843628","https://openalex.org/W2413057841","https://openalex.org/W2419512388","https://openalex.org/W2427569340","https://openalex.org/W2489380216","https://openalex.org/W2889946516"],"related_works":["https://openalex.org/W4324387509","https://openalex.org/W2086799757","https://openalex.org/W2140804130","https://openalex.org/W2732921511","https://openalex.org/W2115276091","https://openalex.org/W4297984429","https://openalex.org/W1938746192","https://openalex.org/W1998784680","https://openalex.org/W193076579","https://openalex.org/W4390744732"],"abstract_inverted_index":{"The":[0,93],"photoaffinity":[1],"labeling":[2],"of":[3,27,35,90,133,164,178,180,190],"amino":[4],"acid":[5],"residues":[6,29],"embedded":[7],"in":[8,12,30,151],"the":[9,31,36,58,66,85,88,91,109,119,125,134,138,155,165,171,176,183,188,191],"lipid":[10],"bilayer,":[11],"combination":[13],"with":[14,84,106],"site-directed":[15],"mutagenesis":[16],"and":[17,41,50,100,108,121,141,149],"patch-clamp":[18],"electrophysiology,":[19],"are":[20,130,153],"beginning":[21],"to":[22,42,46,174,187],"delineate":[23],"a":[24],"topographic":[25],"map":[26],"lipid-sensitive":[28],"transmembrane":[32],"(TM)":[33],"region":[34],"nicotinic":[37],"acetylcholine":[38],"receptor":[39,192],"(nAChR),":[40],"dissect":[43],"their":[44],"contribution":[45],"channel":[47,120],"gating,":[48],"opening":[49],"closing":[51],"mechanisms.":[52],"Recent":[53],"structural":[54],"data":[55],"reveal":[56],"that":[57,157],"TM":[59,185],"segments":[60,76],"form":[61],"three":[62],"concentric":[63],"layers":[64],"around":[65],"ion":[67,135],"channel.":[68,92],"An":[69],"inner":[70],"ring,":[71,116],"shaped":[72],"by":[73,98],"five":[74],"M2":[75],"(one":[77],"from":[78,82,118,124,182],"each":[79],"subunit)":[80],"excluded":[81],"contact":[83,105],"lipid,":[86],"forms":[87],"walls":[89],"middle":[94,126,140],"ring":[95],"is":[96,173],"formed":[97],"M1":[99],"M3":[101],"segments,":[102],"which":[103],"exhibit":[104],"lipids,":[107],"M4":[110],"membrane-embedded":[111],"domains":[112],"constitute":[113],"an":[114],"outer":[115,142],"distant":[117],"loosely":[122],"separated":[123],"ring.":[127],"Although":[128],"they":[129],"not":[131],"part":[132],"conduction":[136],"pathway,":[137],"lipid-exposed":[139,184],"rings":[143,186],"significantly":[144],"modulate":[145],"nAChR":[146],"function.":[147],"Sterols":[148],"steroids,":[150],"particular,":[152],"among":[154],"ligands":[156],"act":[158],"on":[159],"this":[160],"functionally":[161],"relevant":[162],"moiety":[163],"nAChR.":[166],"A":[167],"major":[168],"challenge":[169],"for":[170],"future":[172],"elucidate":[175],"mechanism":[177],"propagation":[179],"information":[181],"rest":[189],"molecule.":[193]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}