{"id":"https://openalex.org/W2415060193","doi":"https://doi.org/10.1152/ajpgi.1994.267.4.g723","title":"Dual pathways regulate neurite outgrowth in enteric ganglia","display_name":"Dual pathways regulate neurite outgrowth in enteric ganglia","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W2415060193","doi":"https://doi.org/10.1152/ajpgi.1994.267.4.g723","mag":"2415060193","pmid":"https://pubmed.ncbi.nlm.nih.gov/7943337"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.1994.267.4.g723","doi":"https://doi.org/10.1152/ajpgi.1994.267.4.g723","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1994.267.4.g723","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030459924","display_name":"Diane M. Simeone","orcid":"https://orcid.org/0000-0001-5142-3087","observed_orcids":["https://orcid.org/0000-0001-5142-3087"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. M. Simeone","raw_affiliation_strings":["Department of Surgery, University of Michigan, Ann Arbor48109-0331"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Michigan, Ann Arbor48109-0331","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046547291","display_name":"Gail L. Romanchuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Romanchuk","raw_affiliation_strings":["Department of Surgery, University of Michigan, Ann Arbor48109-0331"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Michigan, Ann Arbor48109-0331","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109110150","display_name":"M. W. Mulholland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. W. Mulholland","raw_affiliation_strings":["Department of Surgery, University of Michigan, Ann Arbor48109-0331"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Michigan, Ann Arbor48109-0331","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":0.3817,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.67985028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"267","issue":"4","first_page":"G723","last_page":"G729"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.31619998812675476,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.31619998812675476,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.2287999987602234,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.12049999833106995,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.9990000128746033},{"id":"https://openalex.org/keywords/enteric-ganglia","display_name":"enteric ganglia","score":0.902999997138977},{"id":"https://openalex.org/keywords/myenteric-plexus","display_name":"myenteric plexus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.7250000238418579},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.8870000243186951},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cholera-toxin","display_name":"cholera toxin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dibutyryl-camp","display_name":"dibutyryl cyclic AMP","score":0.9200000166893005},{"id":"https://openalex.org/keywords/8-bromoadenosine","display_name":"8-bromoadenosine","score":0.7900000214576721},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.7620000243186951},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.781000018119812},{"id":"https://openalex.org/keywords/alpha-tubulin","display_name":"alpha-tubulin","score":0.8040000200271606},{"id":"https://openalex.org/keywords/map2","display_name":"MAP2","score":0.9589999914169312},{"id":"https://openalex.org/keywords/enteric-neurons","display_name":"enteric neurons","score":0.7139999866485596},{"id":"https://openalex.org/keywords/growth-signaling","display_name":"growth signaling","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.8292899131774902},{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.7572106719017029},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.6923700571060181},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.634651243686676},{"id":"https://openalex.org/C2776668983","wikidata":"https://www.wikidata.org/wiki/Q210041","display_name":"Cyclic adenosine monophosphate","level":3,"score":0.6285013556480408},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6150826215744019},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.5758113861083984},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5646070241928101},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.55306476354599},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5524208545684814},{"id":"https://openalex.org/C115466790","wikidata":"https://www.wikidata.org/wiki/Q5008667","display_name":"cAMP-dependent pathway","level":4,"score":0.4688013195991516},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.39453762769699097},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28774142265319824},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27172812819480896},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22980889678001404},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005724","descriptor_name":"Ganglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005724","descriptor_name":"Ganglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005724","descriptor_name":"Ganglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009197","descriptor_name":"Myenteric Plexus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009197","descriptor_name":"Myenteric Plexus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015345","descriptor_name":"Oligonucleotide Probes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpgi.1994.267.4.g723","doi":"https://doi.org/10.1152/ajpgi.1994.267.4.g723","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1994.267.4.g723","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:7943337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7943337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3637113118","display_name":"STUDIES OF GASTROINTESTINAL AUTONOMIC DYSFUNCTION","funder_award_id":"R01DK041204","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2398875792","https://openalex.org/W2005309084","https://openalex.org/W2136361222","https://openalex.org/W2050556916","https://openalex.org/W1995324764","https://openalex.org/W1984582175","https://openalex.org/W2094898418","https://openalex.org/W2052849986","https://openalex.org/W2114906050","https://openalex.org/W1967637533"],"abstract_inverted_index":{"Primary":[0],"cultures":[1,43],"of":[2,14,47,52,70,77,82,88,95],"guinea":[3],"pig":[4],"myenteric":[5],"plexus":[6],"ganglia":[7],"were":[8,38],"used":[9],"to":[10,27],"examine":[11],"the":[12,55,74],"ability":[13],"agents":[15],"that":[16],"activate":[17],"adenylate":[18],"cyclase":[19],"or":[20,54],"mimic":[21],"intracellular":[22],"adenosine":[23],"3',5'-cyclic":[24,60,66],"monophosphate":[25,61],"(cAMP)":[26],"stimulate":[28],"morphological":[29],"growth.":[30],"Dose-dependent":[31],"increases":[32],"in":[33,40,115],"neurite":[34],"length":[35],"and":[36,62,99,108],"density":[37],"produced":[39],"enteric":[41,116],"neuronal":[42],"by":[44,106],"forskolin":[45],"(212%":[46],"control),":[48,53],"cholera":[49],"toxin":[50],"(356%":[51],"permeant":[56],"cAMP":[57,78],"analogues":[58,79],"8-bromoadenosine":[59],"dibutyryl":[63],"cAMP.":[64],"(R)-p-adenosine":[65],"monophosphorothioate,":[67],"an":[68],"inhibitor":[69],"cAMP-dependent":[71,89,109],"kinases,":[72,111],"blocked":[73],"growth-promoting":[75],"effects":[76],"but":[80],"not":[81],"nerve":[83],"growth":[84,113],"factor":[85],"(NGF).":[86],"Activation":[87],"signaling":[90,114],"pathways":[91],"also":[92],"increased":[93],"production":[94],"mRNA":[96],"for":[97],"alpha-tubulin":[98],"microtubule-associated":[100],"protein":[101,110],"2.":[102],"Dual":[103],"pathways,":[104],"regulated":[105],"NGF":[107],"influence":[112],"ganglia.":[117]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}