{"id":"https://openalex.org/W2415032012","doi":null,"title":"The effect of cigarette smoke on the permeability of guinea pig airways.","display_name":"The effect of cigarette smoke on the permeability of guinea pig airways.","publication_year":1980,"publication_date":"1980-07-01","ids":{"openalex":"https://openalex.org/W2415032012","mag":"2415032012","pmid":"https://pubmed.ncbi.nlm.nih.gov/7392577"},"language":"en","primary_location":{"id":"pmid:7392577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7392577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001166056","display_name":"Richard C. Boucher","orcid":"https://orcid.org/0000-0002-5745-3989","observed_orcids":["https://orcid.org/0000-0002-5745-3989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R C Boucher","raw_affiliation_strings":["Pulmonary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062315448","display_name":"Jill R. Johnson","orcid":"https://orcid.org/0000-0002-5149-0084","observed_orcids":["https://orcid.org/0000-0002-5149-0084"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J Johnson","raw_affiliation_strings":["McGill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110104546","display_name":"Sadayuki Inou\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S Inoue","raw_affiliation_strings":["McGill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084059846","display_name":"William C. Hulbert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Hulbert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091776168","display_name":"James C. Hogg","orcid":"https://orcid.org/0000-0001-9930-1935","observed_orcids":["https://orcid.org/0000-0001-9930-1935"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C Hogg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6936,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.9303903,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"43","issue":"1","first_page":"94","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.38749998807907104,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.38749998807907104,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.2874000072479248,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.19539999961853027,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cigarette-smoke","display_name":"cigarette smoke","score":0.996999979019165},{"id":"https://openalex.org/keywords/airway-permeability","display_name":"airway permeability","score":0.9729999899864197},{"id":"https://openalex.org/keywords/tracheal-epithelium","display_name":"tracheal epithelium","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.7739999890327454},{"id":"https://openalex.org/keywords/horseradish-peroxidase","display_name":"horseradish peroxidase","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mucosal-barrier","display_name":"mucosal barrier","score":0.8730000257492065},{"id":"https://openalex.org/keywords/airway-epithelial-injury","display_name":"airway epithelial injury","score":0.6439999938011169},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.6359999775886536},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.7814837694168091},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.6604923605918884},{"id":"https://openalex.org/C2777676563","wikidata":"https://www.wikidata.org/wiki/Q413665","display_name":"Horseradish peroxidase","level":3,"score":0.6450679302215576},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.635502815246582},{"id":"https://openalex.org/C131631996","wikidata":"https://www.wikidata.org/wiki/Q1141325","display_name":"Lumen (anatomy)","level":2,"score":0.6051424741744995},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.5378612279891968},{"id":"https://openalex.org/C146088050","wikidata":"https://www.wikidata.org/wiki/Q744818","display_name":"Transmission electron microscopy","level":2,"score":0.45767447352409363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45743849873542786},{"id":"https://openalex.org/C2993351451","wikidata":"https://www.wikidata.org/wiki/Q2386268","display_name":"Cigarette smoke","level":2,"score":0.44110679626464844},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.4282885193824768},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.41360366344451904},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3735528588294983},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3554147481918335},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2805101275444031},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2731911540031433},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24495995044708252},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20275980234146118},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.08203020691871643},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0636742115020752},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.0},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000403","descriptor_name":"Airway Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006735","descriptor_name":"Horseradish Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010947","descriptor_name":"Plants, Toxic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012906","descriptor_name":"Smoke","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7392577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7392577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:2415032012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7392577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2185798170","https://openalex.org/W2074202665","https://openalex.org/W2059830823","https://openalex.org/W2415891726","https://openalex.org/W2296022357","https://openalex.org/W2095870712","https://openalex.org/W4299730970","https://openalex.org/W1967975328","https://openalex.org/W2059167065","https://openalex.org/W2325683243"],"abstract_inverted_index":{"The":[0],"epithelium":[1,56,67,121],"lining":[2],"the":[3,7,14,20,26,41,50,54,61,75,83,103,119,124,129,149,159,170,177],"conducting":[4],"airways":[5,51],"restricts":[6],"movement":[8,44],"of":[9,28,31,43,45,63,77,95,100,135,179],"inhaled":[10,32,155],"foreign":[11],"materials":[12],"into":[13,57,65,106],"interstitial":[15],"and":[16,72,92,144,162,174],"circulatory":[17],"space.":[18],"In":[19],"present":[21],"study,":[22],"we":[23],"have":[24],"investigated":[25],"effects":[27],"graded":[29],"doses":[30],"whole":[33,96],"cigarette":[34,156],"smoke":[35,97,157],"on":[36],"this":[37,191],"function":[38],"by":[39,59,73,168],"measuring":[40,176],"rate":[42],"horseradish":[46],"peroxidase":[47],"(HRP)":[48],"from":[49,102],"lumen":[52,105],"across":[53],"tracheal":[55,66,78,104,120],"blood,":[58],"assessing":[60,190],"penetration":[62,99],"HRP":[64,101,117,167,180],"using":[68,82],"transmission":[69],"electron":[70,113,187],"microscopy,":[71],"examining":[74],"morphology":[76],"epithelial":[79,136],"tight":[80,137,172],"junctions":[81,173],"freeze-fracture":[84,130],"technique.":[85],"These":[86],"studies":[87,131],"showed":[88,115,132],"that":[89,116,154,175],"5,":[90],"20,":[91],"100":[93],"puffs":[94],"increased":[98,164],"blood":[107,182],"in":[108,123,181,189],"a":[109,141],"dose-dependent":[110],"fashion.":[111],"Transmission":[112],"microscopy":[114,188],"penetrated":[118],"only":[122],"100-puff":[125,142],"exposure":[126,143],"group":[127],"while":[128],"progressive":[133],"disruption":[134],"junction":[138],"beginning":[139],"with":[140],"becoming":[145],"more":[146,184],"extensive":[147],"after":[148],"200-puff":[150],"exposure.":[151],"We":[152],"conclude":[153],"damages":[158],"mucosal":[160],"barrier":[161],"causes":[163],"permeability":[165],"to":[166],"disrupting":[169],"intercellular":[171],"appearance":[178],"is":[183],"sensitive":[185],"than":[186],"damage.":[192]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}