{"id":"https://openalex.org/W2415030307","doi":null,"title":"Cytochemical and immunocytochemical study on the peroxisomes of rat liver after administration of a hypolipidemic drug, MLM-160.","display_name":"Cytochemical and immunocytochemical study on the peroxisomes of rat liver after administration of a hypolipidemic drug, MLM-160.","publication_year":1990,"publication_date":"1990-10-01","ids":{"openalex":"https://openalex.org/W2415030307","mag":"2415030307","pmid":"https://pubmed.ncbi.nlm.nih.gov/1981745"},"language":"en","primary_location":{"id":"pmid:1981745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1981745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cell biology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078076917","display_name":"Sadaki Yokota","orcid":"https://orcid.org/0000-0002-6315-0394","observed_orcids":["https://orcid.org/0000-0002-6315-0394"]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"S Yokota","raw_affiliation_strings":["Department of Anatomy, Yamanashi Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Yamanashi Medical School, Japan","institution_ids":["https://openalex.org/I66906201"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078076917"],"corresponding_institution_ids":["https://openalex.org/I66906201"],"apc_list":null,"apc_paid":null,"fwci":0.2392,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.48485745,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"53","issue":"1","first_page":"112","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.4392000138759613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.4392000138759613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.1826999932527542,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.08969999849796295,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxisomes","display_name":"peroxisomes","score":0.8849999904632568},{"id":"https://openalex.org/keywords/lipid-lowering-drugs","display_name":"lipid-lowering drugs","score":0.9179999828338623},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.453000009059906},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.7080000042915344},{"id":"https://openalex.org/keywords/d-amino-acid-oxidase","display_name":"D-amino acid oxidase","score":0.8849999904632568},{"id":"https://openalex.org/keywords/glycolate-oxidase","display_name":"glycolate oxidase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/urate-oxidase","display_name":"uricase","score":1.0},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9860000014305115},{"id":"https://openalex.org/keywords/enzyme-localization","display_name":"enzyme localization","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.9803876876831055},{"id":"https://openalex.org/C2776943133","wikidata":"https://www.wikidata.org/wiki/Q18057009","display_name":"Urate oxidase","level":3,"score":0.8752520084381104},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.6882716417312622},{"id":"https://openalex.org/C12296475","wikidata":"https://www.wikidata.org/wiki/Q1149158","display_name":"Microbody","level":4,"score":0.6733464598655701},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.6185239553451538},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5905705094337463},{"id":"https://openalex.org/C2778239910","wikidata":"https://www.wikidata.org/wiki/Q24785797","display_name":"D-amino acid oxidase","level":4,"score":0.41966283321380615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4016568660736084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37870723009109497},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3661438822746277},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13892501592636108}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003605","descriptor_name":"D-Amino-Acid Oxidase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008830","descriptor_name":"Microbodies","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008830","descriptor_name":"Microbodies","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014503","descriptor_name":"Urate Oxidase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1981745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1981745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cell biology","raw_type":"Journal Article"},{"id":"mag:2415030307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1981745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1988127810","https://openalex.org/W2123740843","https://openalex.org/W1968207526","https://openalex.org/W2405074996","https://openalex.org/W7096767534","https://openalex.org/W1965173270","https://openalex.org/W2063861425","https://openalex.org/W2101812574","https://openalex.org/W193047871","https://openalex.org/W2055854976"],"abstract_inverted_index":{"After":[0],"administration":[1,169],"of":[2,22,40,60,106,113,157,170,182,188],"a":[3,114,154],"hypolipidemic":[4],"drug,":[5],"MLM-160,":[6],"to":[7,33,123,172],"male":[8,173],"rats,":[9],"liver":[10,198],"peroxisomes":[11,100,121,199],"were":[12],"studied":[13],"by":[14,35,45],"biochemical,":[15],"cytochemical,":[16],"and":[17,28,68,81,104],"immunocytochemical":[18],"methods.":[19],"The":[20,38,62,185],"activities":[21],"D-amino":[23,78,147],"acid":[24,79,148],"oxidase,":[25,27],"glycolate":[26],"urate":[29,82],"oxidase":[30,80,83,140,149],"increased":[31],"2":[32],"3-fold":[34],"the":[36,41,57,107,111,130,132,137,144,158,161,168,180,197],"treatment.":[37,74],"increase":[39],"oxidases":[42],"was":[43,54,84,134,141,150,163],"confirmed":[44],"immunoblotting":[46],"analysis.":[47],"By":[48,96],"light":[49],"microscopy,":[50,98],"immunoreaction":[51],"for":[52,77],"catalase":[53,133,162],"present":[55,85],"in":[56,86,136,153,202],"cytoplasmic":[58],"granules":[59,64,89],"hepatocytes.":[61],"stained":[63],"formed":[65],"some":[66,176],"clusters":[67],"overlapped":[69],"each":[70,94,127],"other":[71],"after":[72],"MLM-160":[73,171],"However,":[75],"immunostaining":[76],"discrete":[87],"fine":[88],"which":[90],"did":[91],"not":[92],"overlap":[93],"other.":[95,128],"electron":[97],"many":[99,117],"showed":[101],"ring-like":[102],"extensions":[103],"cavitation":[105],"matrix,":[108],"often":[109],"giving":[110],"appearance":[112,181],"peroxisome-within-a-peroxisome.":[115],"In":[116,166],"cases,":[118],"these":[119],"unusual":[120,183],"seemed":[122],"be":[124],"interconnected":[125],"with":[126,143],"Within":[129],"peroxisomes,":[131],"localized":[135,151],"matrix.":[138],"Urate":[139],"associated":[142],"crystalloid":[145],"cores.":[146],"focally":[152],"small":[155],"part":[156],"matrix":[159],"where":[160],"mostly":[164],"negative.":[165],"conclusion,":[167],"rats":[174],"induces":[175],"peroxisomal":[177,189],"oxidases,":[178],"accompanying":[179],"peroxisomes.":[184,205],"precise":[186],"localization":[187],"enzymes":[190],"suggested":[191],"that":[192],"there":[193],"are":[194],"subcompartments":[195],"within":[196],"as":[200],"shown":[201],"rat":[203],"kidney":[204]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
