{"id":"https://openalex.org/W2415014285","doi":null,"title":"A phorbol ester-binding inhibitory factor from human placenta. Partial purification, characterization and biological effects.","display_name":"A phorbol ester-binding inhibitory factor from human placenta. Partial purification, characterization and biological effects.","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W2415014285","mag":"2415014285","pmid":"https://pubmed.ncbi.nlm.nih.gov/6598799"},"language":"en","primary_location":{"id":"pmid:6598799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6598799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IARC scientific publications","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063552156","display_name":"\u00c9dith Hamel","orcid":"https://orcid.org/0000-0001-5223-7315","observed_orcids":["https://orcid.org/0000-0001-5223-7315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Hamel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110017570","display_name":"H Yamasaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Yamasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030062106","display_name":"Tayot Jl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Tayot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.18202334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"56","first_page":"157","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-placenta","display_name":"human placenta","score":0.8510000109672546},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9279999732971191},{"id":"https://openalex.org/keywords/non-competitive-inhibition","display_name":"non-competitive inhibition","score":0.6660000085830688},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hexamethylene-bisacetamide","display_name":"hexamethylene bisacetamide","score":0.7170000076293945},{"id":"https://openalex.org/keywords/2-deoxyglucose-uptake","display_name":"2-deoxyglucose uptake","score":0.9330000281333923},{"id":"https://openalex.org/keywords/protein-purification","display_name":"protein purification","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.7502070665359497},{"id":"https://openalex.org/C2780043322","wikidata":"https://www.wikidata.org/wiki/Q2705359","display_name":"Phorbol","level":4,"score":0.5632559657096863},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5488980412483215},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5472695827484131},{"id":"https://openalex.org/C2909761558","wikidata":"https://www.wikidata.org/wiki/Q416716","display_name":"Tetradecanoylphorbol Acetate","level":4,"score":0.46445298194885254},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43718957901000977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43492603302001953},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.43396836519241333},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.43177396059036255},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4162499010562897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41240373253822327},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11701858043670654},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11674168705940247},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.11040198802947998},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.11038023233413696},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003847","descriptor_name":"Deoxyglucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004915","descriptor_name":"Leukemia, Erythroblastic, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004915","descriptor_name":"Leukemia, Erythroblastic, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005622","descriptor_name":"Friend murine leukemia virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010703","descriptor_name":"Phorbol Esters","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010703","descriptor_name":"Phorbol Esters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010704","descriptor_name":"Phorbols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011257","descriptor_name":"Pregnancy Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D011257","descriptor_name":"Pregnancy Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011257","descriptor_name":"Pregnancy Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6598799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6598799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IARC scientific publications","raw_type":"Journal Article"},{"id":"mag:2415014285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6598799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2032306803","https://openalex.org/W2119073637","https://openalex.org/W2054697635","https://openalex.org/W1888903103","https://openalex.org/W1544414329","https://openalex.org/W1974170868","https://openalex.org/W2093477548","https://openalex.org/W1596687358","https://openalex.org/W2017691305","https://openalex.org/W1977336872"],"abstract_inverted_index":{"A":[0],"factor":[1,27],"which":[2],"inhibits":[3],"the":[4,141,154],"binding":[5,25,165],"of":[6,12,53,109,146,156,161,163,205,212,217,219],"3H-phorbol-12,13-dibutyrate":[7],"(PDBu)":[8],"on":[9,72,77,85,98,153],"different":[10],"types":[11],"cells":[13,75,80,88,126,148,223],"has":[14,150],"been":[15],"partially":[16],"purified":[17],"from":[18,208],"human":[19,73,220],"placenta.":[20],"This":[21],"factor,":[22],"phorbol":[23],"ester":[24],"inhibitory":[26],"(PEBIF),":[28],"is":[29,67,95,106],"sensitive":[30],"to":[31,35,197],"pepsin,":[32],"but":[33],"resistant":[34],"trypsin,":[36],"heat":[37],"and":[38,43,62,66,69,84,92,102,129,149,188,215],"acid":[39],"(pH":[40],"3)":[41],"treatments":[42],"can":[44,116,138,177],"be":[45,117],"precipitated":[46],"by":[47,112,119,144,166],"80%":[48],"ethanol":[49],"with":[50,134],"no":[51,130,151],"loss":[52],"activity.":[54],"Inhibition":[55,71],"occurs":[56],"both":[57],"at":[58],"37":[59],"degrees":[60,64],"C":[61,65],"4":[63],"rapid":[68],"reversible.":[70],"epithelial":[74],"(FL),":[76],"mouse":[78,182],"erythroleukaemia":[79],"(FELC":[81],"clone":[82,90,93,100,103],"19-10)":[83],"rat":[86],"liver":[87],"(IAR":[89],"6-1":[91],"20)":[94],"non-competitive,":[96],"whereas":[97],"IAR":[99],"6":[101],"6-7":[104],"it":[105],"competitive.":[107],"Differentiation":[108],"FELC":[110],"induced":[111,143],"hexamethylene":[113],"bisacetamide":[114],"(HMBA)":[115],"inhibited":[118],"12-O-tetradecanoyl":[120],"phorbol-13-acetate":[121],"(TPA)":[122],"only":[123],"if":[124],"TPA-sensitive":[125,147],"are":[127],"used,":[128],"inhibition":[131,162,211],"was":[132,168],"observed":[133],"TPA-resistant":[135,157],"cells.":[136,158],"PEBIF":[137,167,176,189,195],"also":[139],"inhibit":[140],"differentiation":[142,155,218],"HMBA":[145],"effect":[152],"The":[159],"extent":[160],"PDBu":[164],"similar":[169],"in":[170,181],"these":[171],"two":[172,191],"clones.":[173],"Like":[174],"TPA,":[175],"increase":[178],"2-deoxyglucose":[179],"uptake":[180],"fibroblasts":[183],"(BALB/3T3":[184],"cells).":[185],"Thus,":[186],"TPA":[187,200],"share":[190],"biological":[192],"responses;":[193],"however,":[194],"failed":[196],"mimic":[198],"other":[199],"effects,":[201],"such":[202],"as":[203],"induction":[204,216],"Epstein-Barr":[206],"virus":[207],"Raji":[209],"cells,":[210],"intercellular":[213],"communication":[214],"promyelocytic":[221],"leukaemia":[222],"(HL-60).":[224]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
