{"id":"https://openalex.org/W2414944773","doi":null,"title":"Suitability of limited sampling strategy to cyclosporine A oral formulation.","display_name":"Suitability of limited sampling strategy to cyclosporine A oral formulation.","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W2414944773","mag":"2414944773","pmid":"https://pubmed.ncbi.nlm.nih.gov/12557917"},"language":"en","primary_location":{"id":"pmid:12557917","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12557917","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107947710","display_name":"Panacea Biotec (India)","ror":"https://ror.org/01ew11x49","country_code":"IN","type":"company","lineage":["https://openalex.org/I107947710"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S Singh","raw_affiliation_strings":["Department of Medical Research, Panacea Biotec Ltd., B-1 Ext./A-27, Mohan Co-op Industrial Estate, Mathura Road, New Delhi 110 044, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Panacea Biotec Ltd., B-1 Ext./A-27, Mohan Co-op Industrial Estate, Mathura Road, New Delhi 110 044, India","institution_ids":["https://openalex.org/I107947710"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D R Sharma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D R Sharma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5105367284","display_name":"\u00c0marjit Singh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32580262,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"8","first_page":"824","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/limited-sampling-strategy","display_name":"limited sampling strategy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.8500000238418579},{"id":"https://openalex.org/keywords/area-under-the-curve","display_name":"area under the curve","score":0.777999997138977},{"id":"https://openalex.org/keywords/oral-formulations","display_name":"oral dosage forms","score":0.5640000104904175},{"id":"https://openalex.org/keywords/kidney-transplant-patients","display_name":"renal transplant patients","score":0.7919999957084656},{"id":"https://openalex.org/keywords/hemodialysis-patients","display_name":"hemodialysis patients","score":0.9539999961853027},{"id":"https://openalex.org/keywords/formulation-comparison","display_name":"formulation comparison","score":0.5090000033378601},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.6369284391403198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5543684363365173},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.5339376330375671},{"id":"https://openalex.org/C31785415","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough level","level":4,"score":0.46260035037994385},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.46123337745666504},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.44226595759391785},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.4099857807159424},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.3703935146331787},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3459114134311676},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3398430347442627},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.25244665145874023},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.24945098161697388},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22944161295890808},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.09738734364509583},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12557917","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12557917","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Journal Article"},{"id":"mag:2414944773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12557917","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1561424141","https://openalex.org/W1970816631","https://openalex.org/W1981801952","https://openalex.org/W2014323250","https://openalex.org/W2023031826","https://openalex.org/W2049170691","https://openalex.org/W2085415545","https://openalex.org/W2094944937","https://openalex.org/W2103728625","https://openalex.org/W2116331241","https://openalex.org/W2323911314","https://openalex.org/W2335210339","https://openalex.org/W2409487187","https://openalex.org/W2409599255","https://openalex.org/W2412463225","https://openalex.org/W2414989413","https://openalex.org/W2462240851"],"related_works":["https://openalex.org/W1992303861","https://openalex.org/W2044426904","https://openalex.org/W2086502379","https://openalex.org/W2323911314","https://openalex.org/W2315821671","https://openalex.org/W2305826146","https://openalex.org/W1985179193","https://openalex.org/W1973595469","https://openalex.org/W2320453028","https://openalex.org/W4242760493"],"abstract_inverted_index":{"Therapeutic":[0],"drug":[1],"monitoring":[2],"of":[3,33,76],"cyclosporine":[4,78],"A":[5,79],"in":[6],"renal":[7],"transplant":[8],"patients":[9,82],"is":[10],"normally":[11],"performed":[12],"by":[13],"measuring":[14],"pre-dose":[15],"trough":[16],"levels":[17],"or":[18],"doing":[19],"area":[20,38,48],"under":[21,39,49],"the":[22,31,40,50,87],"curve":[23,41,51],"profiles":[24],"from":[25,42],"all":[26],"possible":[27],"sampling":[28,44,56],"points.":[29],"On":[30],"basis":[32],"good":[34],"correlation":[35],"between":[36],"predicted":[37],"limited":[43,55],"points":[45],"and":[46,61,66],"actual":[47],"(literature":[52],"survey),":[53],"a":[54,71,94],"strategy":[57,69],"at":[58],"1,":[59],"3":[60],"5":[62],"hr":[63],"was":[64,91],"used":[65,92],"extended":[67],"this":[68],"as":[70,84,93,100],"criteria":[72],"for":[73,86],"pilot":[74],"evaluation":[75],"modified":[77],"formulations.":[80],"Hemodialysis":[81],"served":[83],"subjects":[85],"study.":[88],"Panimun":[89],"Bioral":[90],"test":[95],"formulation":[96],"while":[97],"Sandimmun":[98],"Neoral":[99],"standard":[101],"reference.":[102],"The":[103],"study":[104],"revealed":[105],"that":[106],"both":[107],"formulations":[108],"had":[109],"similar":[110],"restricted":[111],"AUC0-5h":[112],"profiles.":[113]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}