{"id":"https://openalex.org/W2414912604","doi":null,"title":"Expression of CDKN1A/p21 and TGFBR2 in breast cancer and their prognostic significance.","display_name":"Expression of CDKN1A/p21 and TGFBR2 in breast cancer and their prognostic significance.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2414912604","mag":"2414912604","pmid":"https://pubmed.ncbi.nlm.nih.gov/26823785","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4713571"},"language":"en","primary_location":{"id":"pmid:26823785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26823785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4713571/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101718550","display_name":"Changyuan Wei","orcid":"https://orcid.org/0000-0001-9776-2738","observed_orcids":["https://orcid.org/0000-0001-9776-2738"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210155683","display_name":"Tumor Hospital of Guangxi Medical University","ror":"https://ror.org/051mn8706","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang-Yuan Wei","raw_affiliation_strings":["Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University Nanning 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University Nanning 530021, China","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210155683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101594537","display_name":"Qixing Tan","orcid":"https://orcid.org/0000-0002-8092-7740","observed_orcids":["https://orcid.org/0000-0002-8092-7740"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210155683","display_name":"Tumor Hospital of Guangxi Medical University","ror":"https://ror.org/051mn8706","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi-Xing Tan","raw_affiliation_strings":["Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University Nanning 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University Nanning 530021, China","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210155683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110070703","display_name":"Xiao Dong Zhu","orcid":"https://orcid.org/0000-0003-0899-5180","observed_orcids":["https://orcid.org/0000-0003-0899-5180"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210155683","display_name":"Tumor Hospital of Guangxi Medical University","ror":"https://ror.org/051mn8706","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Zhu","raw_affiliation_strings":["Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University Nanning 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University Nanning 530021, China","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210155683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050188796","display_name":"Qinghong Qin","orcid":"https://orcid.org/0000-0001-5342-9124","observed_orcids":["https://orcid.org/0000-0001-5342-9124"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210155683","display_name":"Tumor Hospital of Guangxi Medical University","ror":"https://ror.org/051mn8706","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing-Hong Qin","raw_affiliation_strings":["Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University Nanning 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University Nanning 530021, China","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210155683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074365768","display_name":"Zhu Fei-bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099759","display_name":"Wenzhou Central Hospital","ror":"https://ror.org/00w5h0n54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099759"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei-Bai Zhu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Wenzhou Central Hospital Wenzhou 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Wenzhou Central Hospital Wenzhou 325000, China","institution_ids":["https://openalex.org/I4210099759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011497097","display_name":"Qinguo Mo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210155683","display_name":"Tumor Hospital of Guangxi Medical University","ror":"https://ror.org/051mn8706","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin-Guo Mo","raw_affiliation_strings":["Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University Nanning 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University Nanning 530021, China","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210155683"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101141453","display_name":"Weiping Yang","orcid":"https://orcid.org/0009-0008-6946-7254","observed_orcids":["https://orcid.org/0009-0008-6946-7254"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210155683","display_name":"Tumor Hospital of Guangxi Medical University","ror":"https://ror.org/051mn8706","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei-Ping Yang","raw_affiliation_strings":["Department of Ultrasound Diagnosis, The Affiliated Tumor Hospital of Guangxi Medical University Nanning 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound Diagnosis, The Affiliated Tumor Hospital of Guangxi Medical University Nanning 530021, China","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210155683"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2427,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.7550278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"11","first_page":"14619","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/p21-cdkn1a","display_name":"CDKN1A/p21","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tgf-beta-receptor-ii","display_name":"TGFBR2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9729999899864197},{"id":"https://openalex.org/keywords/tumor-suppressor-gene-expression","display_name":"tumor suppressor gene expression","score":0.8009999990463257},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8830000162124634},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.7699999809265137},{"id":"https://openalex.org/keywords/gene-downregulation","display_name":"gene downregulation","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8341885805130005},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6911450624465942},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5595314502716064},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5392696857452393},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5101854801177979},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.48827362060546875},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4569064676761627},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45248088240623474},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4436715245246887},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.431557297706604},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36043649911880493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26639384031295776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077294","descriptor_name":"Receptor, Transforming Growth Factor-beta Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:26823785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26823785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4713571","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4713571/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:2414912604","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26823785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4713571","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4713571/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1577472668","https://openalex.org/W1601446116","https://openalex.org/W1605269201","https://openalex.org/W1935931925","https://openalex.org/W1968056944","https://openalex.org/W1969576046","https://openalex.org/W1977124825","https://openalex.org/W1981831148","https://openalex.org/W1984162437","https://openalex.org/W1991517695","https://openalex.org/W1997508119","https://openalex.org/W1999132074","https://openalex.org/W2008537833","https://openalex.org/W2016920291","https://openalex.org/W2028125989","https://openalex.org/W2033445993","https://openalex.org/W2050380934","https://openalex.org/W2051190668","https://openalex.org/W2051341133","https://openalex.org/W2070061120","https://openalex.org/W2075058989","https://openalex.org/W2079611570","https://openalex.org/W2079984607","https://openalex.org/W2088097413","https://openalex.org/W2098613950","https://openalex.org/W2102807711","https://openalex.org/W2115134414","https://openalex.org/W2115477146","https://openalex.org/W2136280424","https://openalex.org/W2137736336","https://openalex.org/W2140480677","https://openalex.org/W2147908526","https://openalex.org/W2155181257","https://openalex.org/W2157059797","https://openalex.org/W2159023635","https://openalex.org/W2162262059","https://openalex.org/W2169746680","https://openalex.org/W2171981807"],"related_works":["https://openalex.org/W2392621618","https://openalex.org/W1493551679","https://openalex.org/W4310534960","https://openalex.org/W2060623604","https://openalex.org/W2793063263","https://openalex.org/W1981181043","https://openalex.org/W2114302755","https://openalex.org/W2000034979","https://openalex.org/W4242051226","https://openalex.org/W1975514265"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"new":[2],"diagnostic":[3],"and":[4,21,35,54,65,73,84,100,140,153,185,202,214,225,233],"prognostic":[5,43],"biomarker":[6],"may":[7],"be":[8],"of":[9,28,45,52,88,104,150,169],"value":[10],"in":[11,25,109,158,171,206,228],"cancer":[12,32,92,111,160,173,242],"diseases.":[13],"Our":[14],"study":[15],"aimed":[16],"to":[17,36,40,81,85],"evaluate":[18],"the":[19,46,86,98,147],"CDKN1A/p21":[20,53,105,120,201,213,232],"TGFBR2":[22,55,151,170,203,216,234],"level":[23],"measurable":[24],"a":[26,123,141,186],"cohort":[27],"patients":[29,89],"with":[30,90,114,126,163,176,221],"breast":[31,77,91,110,117,159,166,172,229,241],"after":[33],"mastectomy,":[34],"confirm":[37],"their":[38],"suitability":[39],"serve":[41],"as":[42,237],"biomarkers":[44],"cancer.":[47,230],"METHODS:":[48],"The":[49],"expression":[50,102,121,148,217],"levels":[51,103,149],"were":[56,93,106,155],"detected":[57],"by":[58],"reverse":[59],"transcription-PCR":[60],"(RT-PCR),":[61],"western":[62],"blot":[63],"assay":[64],"immunohistochemical":[66],"staining":[67],"for":[68,240],"65":[69],"primary":[70],"tumor":[71,128,132,178],"samples":[72],"paired":[74],"adjacent":[75,115,164],"noncancerous":[76],"tissues.":[78,118,167],"Their":[79],"relations":[80],"clinicopathologic":[82],"parameters":[83,224],"prognosis":[87,227],"analyzed.":[94],"RESULTS:":[95],"We":[96],"found":[97],"mRNA":[99,152],"protein":[101,154],"significantly":[107,156],"upregulated":[108],"tissues":[112,161],"compared":[113,162],"nontumorous":[116,165],"Increased":[119],"showed":[122],"significant":[124,198],"correlation":[125],"larger":[127,177],"size":[129,179],"(P=0.014),":[130],"higher":[131],"dedifferentiation":[133],"grade":[134],"(P=0.021),":[135],"lymph":[136,181],"node":[137,182],"metastasis":[138,183],"(P=0.019)":[139],"shorter":[142,187],"disease-free":[143,188],"survival":[144,189],"(P=0.044).":[145],"Contrarily,":[146],"decreased":[157],"Underexpression":[168],"was":[174,196,218],"correlated":[175,220],"(P=0.034),":[180],"(P=0.039)":[184],"(P=0.035).":[190],"Statistical":[191],"analysis":[192],"suggested":[193,210],"that":[194,211],"there":[195],"no":[197],"association":[199],"between":[200],"expression.":[204],"CONCLUSIONS:":[205],"summary,":[207],"our":[208],"results":[209],"high":[212],"low":[215],"closely":[219],"adverse":[222],"pathological":[223],"poor":[226],"Both":[231],"are":[235],"presented":[236],"possible":[238],"candidates":[239],"biomarkers.":[243]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}